SETLP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SETLP_HUMAN
• UniProt AC: P0DME0
• Protein Name: Protein SETSIP
• Gene Name: SETSIP
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Subcellular Localization: Cytoplasm . Nucleus . Translocated from the cytoplasm to the nucleus in protein-induced pluripotent stem (PiPS) endothelial cells.
• Protein Description: Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter..
• Protein Sequence: MVWFLDFPNSMAPKRQSPLPLQKKKPRPPPALGLEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQDSEEILKVEQKYNKLRQPFFQKRSELIAKIPNFGVTTFVNHPQVSSLLGEEDEEALHYLTKVEVTEFEDIKSGYRIDFYFDENPYFENKVFSKEFHLNESGDPSSKSTKIKWKSGKDVTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELEEVIKDDIWPNPLQYYLVPDMDDEEGGEDDDDDDDDGDEGEEELEDIDEGDEDEGEEDEDDDEGEEGEEDEGEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	SMAPKRQSPLPLQKK CCCCCCCCCCCCCCC		30622161
40	Phosphorylation	GLEETSASAGLPKKG CCCCCCHHCCCCCCC		22817900
49	Acetylation	GLPKKGEKEQQEAIE CCCCCCHHHHHHHHH		26051181
78	Ubiquitination	QDSEEILKVEQKYNK HCHHHHHHHHHHHHH		22817900
82	Succinylation	EILKVEQKYNKLRQP HHHHHHHHHHHHHCC		23954790
82	Ubiquitination	EILKVEQKYNKLRQP HHHHHHHHHHHHHCC		22817900
82	Acetylation	EILKVEQKYNKLRQP HHHHHHHHHHHHHCC		23749302
85	Neddylation	KVEQKYNKLRQPFFQ HHHHHHHHHHCCHHH		32015554
93	Methylation	LRQPFFQKRSELIAK HHCCHHHHHHHHHHC		127455561
93	Ubiquitination	LRQPFFQKRSELIAK HHCCHHHHHHHHHHC		23000965
93	Acetylation	LRQPFFQKRSELIAK HHCCHHHHHHHHHHC		23954790
136	Phosphorylation	YLTKVEVTEFEDIKS HHEEEEEEEEECCCC		23403867
142	Acetylation	VTEFEDIKSGYRIDF EEEEECCCCCEEEEE		23954790
142	Malonylation	VTEFEDIKSGYRIDF EEEEECCCCCEEEEE		26320211
142	Ubiquitination	VTEFEDIKSGYRIDF EEEEECCCCCEEEEE		23000965
142	Methylation	VTEFEDIKSGYRIDF EEEEECCCCCEEEEE		80475811
143	Phosphorylation	TEFEDIKSGYRIDFY EEEECCCCCEEEEEE		22167270
145	Phosphorylation	FEDIKSGYRIDFYFD EECCCCCEEEEEEEC		23403867
150	Phosphorylation	SGYRIDFYFDENPYF CCEEEEEEECCCCCC		27259358
156	Phosphorylation	FYFDENPYFENKVFS EEECCCCCCCCCEEC		25884760
171	Phosphorylation	KEFHLNESGDPSSKS EEECCCCCCCCCCCC		30266825
175	Phosphorylation	LNESGDPSSKSTKIK CCCCCCCCCCCCCCE		30266825
176	Phosphorylation	NESGDPSSKSTKIKW CCCCCCCCCCCCCEE		30266825
194	Phosphorylation	KDVTKRSSQTQNKAS CCCHHHCHHHCCHHH		-
199	Ubiquitination	RSSQTQNKASRKRQH HCHHHCCHHHHHHHH		-
201	Phosphorylation	SQTQNKASRKRQHEE HHHCCHHHHHHHHCC		-
211	Phosphorylation	RQHEEPESFFTWFTD HHHCCCHHHHHHHCC		22468782
217	Phosphorylation	ESFFTWFTDHSDAGA HHHHHHHCCCCCCCH		22468782
220	Phosphorylation	FTWFTDHSDAGADEL HHHHCCCCCCCHHHH		22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SETLP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SETLP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SETLP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P3H1_HUMAN	P3H1	physical	22863883
NRDC_HUMAN	NRD1	physical	22863883
PFD1_HUMAN	PFDN1	physical	22863883
TSN_HUMAN	TSN	physical	22863883
VAT1_HUMAN	VAT1	physical	22863883

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.