RCAN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCAN2_HUMAN
• UniProt AC: Q14206
• Protein Name: Calcipressin-2
• Gene Name: RCAN2
• Organism: Homo sapiens (Human).
• Sequence Length: 197
• Protein Description: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development..
• Protein Sequence: MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	29.38	23663014
6 (in isoform 2)	Phosphorylation	-	6.06	23663014
112	Phosphorylation	PAKQFLISPPSSPPV CCHHEEECCCCCCCC	32.67	27251275
115	Phosphorylation	QFLISPPSSPPVGWQ HEEECCCCCCCCCCC	59.88	28348404
116	Phosphorylation	FLISPPSSPPVGWQP EEECCCCCCCCCCCC	38.71	28348404
128	Phosphorylation	WQPINDATPVLNYDL CCCCCCCCCCCCHHH	19.45	27251275
158	Phosphorylation	HAGTESTPSVVVHVC ECCCCCCCEEEEEEC	34.11	27251275
162	Phosphorylation	ESTPSVVVHVCDSDI CCCCEEEEEECCCCC	2.34	27251275
167	Phosphorylation	VVVHVCDSDIEEEED EEEEECCCCCCCCCC	35.05	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCAN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCAN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCAN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOC_HUMAN	TCEB1	physical	21988832
PP2BB_HUMAN	PPP3CB	physical	26186194
PP2BC_HUMAN	PPP3CC	physical	26186194
PP2BA_HUMAN	PPP3CA	physical	26186194
MAAI_HUMAN	GSTZ1	physical	26186194
CANB1_HUMAN	PPP3R1	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
SPA12_HUMAN	SERPINA12	physical	26186194
MUC7_HUMAN	MUC7	physical	26186194
SPRR3_HUMAN	SPRR3	physical	26186194
GSK3B_HUMAN	GSK3B	physical	26186194
GSK3A_HUMAN	GSK3A	physical	26186194
CRNN_HUMAN	CRNN	physical	26186194
CYTS_HUMAN	CST4	physical	26186194
CYTT_HUMAN	CST2	physical	26186194
ARMT1_HUMAN	C6orf211	physical	26186194
PP2BC_HUMAN	PPP3CC	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
PP2BB_HUMAN	PPP3CB	physical	28514442
PP2BA_HUMAN	PPP3CA	physical	28514442
GSK3A_HUMAN	GSK3A	physical	28514442
CRNN_HUMAN	CRNN	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
HSBP1_HUMAN	HSBP1	physical	28514442
MUC7_HUMAN	MUC7	physical	28514442
ARMT1_HUMAN	C6orf211	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
GBB3_HUMAN	GNB3	physical	28514442
TFG_HUMAN	TFG	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.