SPRR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPRR3_HUMAN
• UniProt AC: Q9UBC9
• Protein Name: Small proline-rich protein 3
• Gene Name: SPRR3
• Organism: Homo sapiens (Human).
• Sequence Length: 169
• Subcellular Localization: Cytoplasm.
• Protein Description: Cross-linked envelope protein of keratinocytes..
• Protein Sequence: MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPGPAQQKTKQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSYQQKQT ------CCHHHCCCC	37.44	20599699
9	Phosphorylation	SSYQQKQTFTPPPQL CHHHCCCCCCCCHHH	36.19	29759185
11	Phosphorylation	YQQKQTFTPPPQLQQ HHCCCCCCCCHHHHH	37.97	27966365
106	Phosphorylation	TKVPEPGYTKVPEPG CCCCCCCCCCCCCCC	17.69	-
114	Phosphorylation	TKVPEPGSIKVPDQG CCCCCCCCEECCCCC	29.92	21299198
146	Phosphorylation	TKVPVPGYTKLPEPC EECCCCCCCCCCCCC	8.47	-
147	Phosphorylation	KVPVPGYTKLPEPCP ECCCCCCCCCCCCCC	31.83	-
158	Phosphorylation	EPCPSTVTPGPAQQK CCCCCCCCCCHHHHH	23.71	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPRR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPRR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPRR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JOS2_HUMAN	JOSD2	physical	26186194
JOS2_HUMAN	JOSD2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Characterization of two isoforms of human SPRR3 from saliva ofpreterm human newborn and autoptic fetal oral mucosa, parotid andsubmandibular gland samples.";
Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R.,Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C.,Faa G., Castagnola M., Messana I.;
Biochem. Biophys. Res. Commun. 398:477-481(2010).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATORMETHIONINE, ACETYLATION AT SER-2, AND VARIANTS DEL 98-CYS--PRO-104 ANDVAL-149.
PubMed: 20599699