PISD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PISD_HUMAN
• UniProt AC: Q9UG56
• Protein Name: Phosphatidylserine decarboxylase proenzyme, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03208}
• Gene Name: PISD {ECO:0000255|HAMAP-Rule:MF_03208}
• Organism: Homo sapiens (Human).
• Sequence Length: 409
• Subcellular Localization: Phosphatidylserine decarboxylase beta chain: Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .; Phosphatidylserine decarboxylase alpha chain: Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side
• Protein Description: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine..
• Protein Sequence: MATSVGHRCLGLLHGVAPWRSSLHPCEITALSQSLQPLRKLPFRAFRTDARKIHTAPARTMFLLRPLPILLVTGGGYAGYRQYEKYRERELEKLGLEIPPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKGSYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	6.95	29083192
37 (in isoform 2)	Phosphorylation	-	39.15	22210691
112	Ubiquitination	HWEVALYKSVPTRLL CEEEEEEECCCHHHH	45.91	-
166	Phosphorylation	LHHYRNLSEFFRRKL HHHHCCHHHHHHHHC	35.59	28857561
201	Ubiquitination	ILNFGQVKNCEVEQV EEECCEEECCEEEEE	48.25	-
209	Ubiquitination	NCEVEQVKGVTYSLE CCEEEEEECEEEEHH	47.56	-
217	Phosphorylation	GVTYSLESFLGPRMC CEEEEHHHHHCCCCC	30.94	28857561
240	Ubiquitination	AASCDSFKNQLVTRE CCCCHHHHCEEEECC	47.97	-
262 (in isoform 2)	Ubiquitination	-	29.01	21890473
262	Ubiquitination	VIYLAPGDYHCFHSP EEEECCCCCCEECCC	29.01	21890473
295 (in isoform 3)	Ubiquitination	-	1.75	21890473
296	Ubiquitination	PGMARWIKELFCHNE HHHHHHHHHHHCCCC	41.21	21890473
312 (in isoform 2)	Ubiquitination	-	38.29	21890473
312	Ubiquitination	VVLTGDWKHGFFSLT EEEECCCCCCEEEEE	38.29	21890473
314	Phosphorylation	LTGDWKHGFFSLTAV EECCCCCCEEEEEEE	22.90	27251275
339	Phosphorylation	YFDRDLHTNSPRHSK EECCCCCCCCCCCCC	44.69	29214152
341	Phosphorylation	DRDLHTNSPRHSKGS CCCCCCCCCCCCCCC	25.19	29214152
345 (in isoform 3)	Ubiquitination	-	39.74	21890473
345	Phosphorylation	HTNSPRHSKGSYNDF CCCCCCCCCCCCCCC	39.74	29214152
346	Ubiquitination	TNSPRHSKGSYNDFS CCCCCCCCCCCCCCE	45.83	2189047
348	Phosphorylation	SPRHSKGSYNDFSFV CCCCCCCCCCCCEEE	25.21	30108239
349	Phosphorylation	PRHSKGSYNDFSFVT CCCCCCCCCCCEEEE	27.67	30108239
353	Phosphorylation	KGSYNDFSFVTHTNR CCCCCCCEEEEEECC	22.98	28857561
378	Pyruvate	LGEFNLGSTIVLIFE CCCCCCCCEEEEEEE	20.37	-
378	Pyruvic acid (Ser)	LGEFNLGSTIVLIFE CCCCCCCCEEEEEEE	20.37	-
395	Ubiquitination	KDFNFQLKTGQKIRF CCCCCEECCCCEEEE	39.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PISD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PISD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PISD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHX29_HUMAN	DHX29	physical	16169070
DGLB_HUMAN	DAGLB	physical	16169070
IF140_HUMAN	IFT140	physical	27173435
WDR19_HUMAN	WDR19	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00144: Phosphatidylserine