ZN223_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN223_HUMAN
• UniProt AC: Q9UK11
• Protein Name: Zinc finger protein 223
• Gene Name: ZNF223
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MTMSKEAVTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQPFHRDTFHFLREEKFWMMDIATQREGNSGGKIQPEMKTFPEAGPHEGWSCQQIWEEIASDLTRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDMSIFDLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLHLQTHQRVHTGEKPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEACGRAFIHDFQLQKHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGEYGKGFIRRLDLCKHQTIHTGEKPYNCKECGKSFRRSSYLLIHQRVHTGEKPYKCDKCGKSYITKSGLDLHHRAHTGERPYNCDDCGKSFRQASSILNHKRLHCRKKPFKCEDCGKKLVYRSYRKDQQKNHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	KDVAVVFTEEELGLL CCEEEEEEHHHHCHH	30.77	-
31	Sumoylation	LLDLAQRKLYRDVML HHHHHHHHHHHHHHH	37.48	-
31	Sumoylation	LLDLAQRKLYRDVML HHHHHHHHHHHHHHH	37.48	-
227	Phosphorylation	QTHQRVHTGEKPFKC CCCCCCCCCCCCEEC	44.15	23898821
283	Phosphorylation	QKHQRIHTGEKPFKC HCCCCCCCCCCCCEE	44.67	18669648
296	Phosphorylation	KCEICSVSFRLRSSL EEEECEEEEEEHHHH	6.59	24719451
356	Phosphorylation	CGKSFRRSSYLLIHQ HHHCHHHHCEEEEEE	21.05	24247654
367	Phosphorylation	LIHQRVHTGEKPYKC EEEEEECCCCCCCCC	44.15	29496963
370	Sumoylation	QRVHTGEKPYKCDKC EEECCCCCCCCCCCC	55.80	-
370	Sumoylation	QRVHTGEKPYKCDKC EEECCCCCCCCCCCC	55.80	-
370	Ubiquitination	QRVHTGEKPYKCDKC EEECCCCCCCCCCCC	55.80	-
372	Phosphorylation	VHTGEKPYKCDKCGK ECCCCCCCCCCCCCC	35.00	-
395	Phosphorylation	DLHHRAHTGERPYNC CCCCCCCCCCCCCCC	39.49	29116813
425	Acetylation	HKRLHCRKKPFKCED CCCHHCCCCCCCCCC	70.91	20167786
436	Acetylation	KCEDCGKKLVYRSYR CCCCCCCEEEEEHHC	28.59	20167786
457	Ubiquitination	HSGENPSKCEDCGKR CCCCCCHHHCHHHHH	42.79	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN223_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN223_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN223_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZC4H2_HUMAN	ZC4H2	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
TRI39_HUMAN	TRIM39	physical	28514442
CENPB_HUMAN	CENPB	physical	28514442
TRI41_HUMAN	TRIM41	physical	28514442
ZN430_HUMAN	ZNF430	physical	28514442
ZN284_HUMAN	ZNF284	physical	28514442
ZNF92_HUMAN	ZNF92	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
STRN4_HUMAN	STRN4	physical	28514442
HAUS4_HUMAN	HAUS4	physical	28514442
ZN714_HUMAN	ZNF714	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
TIF1B_HUMAN	TRIM28	physical	28514442
MTCL1_HUMAN	MTCL1	physical	28514442
ANR52_HUMAN	ANKRD52	physical	28514442
HECD1_HUMAN	HECTD1	physical	28514442
HERC1_HUMAN	HERC1	physical	28514442
PPM1G_HUMAN	PPM1G	physical	28514442
STRP1_HUMAN	STRIP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.