LRRN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRN4_HUMAN
• UniProt AC: Q8WUT4
• Protein Name: Leucine-rich repeat neuronal protein 4
• Gene Name: LRRN4
• Organism: Homo sapiens (Human).
• Sequence Length: 740
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May play an important role in hippocampus-dependent long-lasting memory..
• Protein Sequence: MRQTLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNATDSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGNPLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQLPGVCQSDQSTTLGASHPPCFNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAWPHSDAREGTAPSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAPELVLEPDISAASTPLASKLLGPFPTSWDRSISSPQPGQRTHATPQAPNPSLSEGEIPVLLLDDYSEEEEGRKEEVGTPHQDVPCDYHPCKHLQTPCAELQRRWRCRCPGLSGEDTIPDPPRLQGVTETTDTSALVHWCAPNSVVHGYQIRYSAEGWAGNQSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLSQPRSSGWRSPCAAFTTKPSFALLLSGLCAASGLLLASTVVLSACLCRRGQTLGLQRCDTHLVAYKNPAFDDYPLGLQTVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRQTLPLLLLT ----CCCCHHHHHHH	21.70	-
11	Phosphorylation	TLPLLLLTVLRPSWA CHHHHHHHHHCCCCC	19.91	-
42	N-linked_Glycosylation	PWGSSGSNATDSPCE CCCCCCCCCCCCCCC	50.84	UniProtKB CARBOHYD
44	O-linked_Glycosylation	GSSGSNATDSPCEGL CCCCCCCCCCCCCCC	41.06	OGP
146	Phosphorylation	PCTGPALSSLRALAL CCCCHHHHHHHHHHH	29.45	30301811
147	Phosphorylation	CTGPALSSLRALALA CCCHHHHHHHHHHHC	23.79	25954137
176	N-linked_Glycosylation	FPALQLLNLSCTALG HHHHHHHHHHHHHCC	38.20	UniProtKB CARBOHYD
231	Phosphorylation	IRDLPKLTSLYLRKM CCCHHHHHHHHHHHC	23.86	-
232	Phosphorylation	RDLPKLTSLYLRKMP CCHHHHHHHHHHHCC	26.00	24719451
234	Phosphorylation	LPKLTSLYLRKMPRL HHHHHHHHHHHCCCC	12.29	24719451
289	N-linked_Glycosylation	VLLFQNCNLSSFPPW EEEEECCCCCCCCCC	50.97	UniProtKB CARBOHYD
332	Phosphorylation	DAKRTVLSRAADTMC HHHHHHHHHHHHCCC	18.61	24702127
379	N-linked_Glycosylation	ASHPPCFNRSTYAQG CCCCCCCCCCCCCCC	43.65	UniProtKB CARBOHYD
416	O-linked_Glycosylation	APNVGSRTIAAWPHS CCCCCCCCEEEECCC	19.37	55835491
423	O-linked_Glycosylation	TIAAWPHSDAREGTA CEEEECCCCCCCCCC	28.96	55835497
436	Phosphorylation	TAPSTTNSVAGHSNS CCCCCCCCCCCCCCC	15.97	30576142
441	Phosphorylation	TNSVAGHSNSSVFPR CCCCCCCCCCCCCCC	37.17	30576142
442	N-linked_Glycosylation	NSVAGHSNSSVFPRA CCCCCCCCCCCCCCC	32.41	UniProtKB CARBOHYD
443	Phosphorylation	SVAGHSNSSVFPRAA CCCCCCCCCCCCCCC	30.78	24667141
444	Phosphorylation	VAGHSNSSVFPRAAS CCCCCCCCCCCCCCC	31.84	24667141
452	Phosphorylation	VFPRAASTTRTQHRG CCCCCCCCCCCCCCC	18.64	30576142
540	O-linked_Glycosylation	GRKEEVGTPHQDVPC CCCCCCCCCCCCCCC	23.83	OGP
610	Phosphorylation	PNSVVHGYQIRYSAE CCCEECEEEEEEECC	5.96	25332170
614	Phosphorylation	VHGYQIRYSAEGWAG ECEEEEEEECCCCCC	17.54	-
622	N-linked_Glycosylation	SAEGWAGNQSVVGVI ECCCCCCCCCEEEEE	24.17	UniProtKB CARBOHYD
624	Phosphorylation	EGWAGNQSVVGVIYA CCCCCCCCEEEEEEE	23.83	25332170
630	Phosphorylation	QSVVGVIYATARQHP CCEEEEEEEECCCCC	8.76	25332170
660	Phosphorylation	AANRAGLSQPRSSGW HHHHCCCCCCCCCCC	36.90	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRRN4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.