THEG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THEG_HUMAN
• UniProt AC: Q9P2T0
• Protein Name: Testicular haploid expressed gene protein
• Gene Name: THEG
• Organism: Homo sapiens (Human).
• Sequence Length: 379
• Subcellular Localization: Nucleus. Localized predominantly in the nucleus of haploid round spermatid..
• Protein Description: May be involved (but not essential) in spermatogenesis..
• Protein Sequence: MGDSRRRSLGNQPSSEAAGRSEREQDGDPRGLQSSVYESRRVTDPERQDLDNAELGPEDPEEELPPEEVAGEEFPETLDPKEALSELERVLDKDLEEDIPEISRLSISQKLPSTTMTKARKRRRRRRLMELAEPKINWQVLKDRKGRCGKGYAWISPCKMSLHFCLCWPSVYWTERFLEDTTLTITVPAVSRRVEELSRPKRFYLEYYNNNRTTPVWPIPRSSLEYRASSRLKELAAPKIRDNFWSMPMSEVSQVSRAAQMAVPSSRILQLSKPKAPATLLEEWDPVPKPKPHVSDHNRLLHLARPKAQSDKCVPDRDPRWEVLDVTKKVVASPRIISLAKPKVRKGLNEGYDRRPLASMSLPPPKASPEKCDQPRPGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGDSRRRSLGNQPSS CCHHHHHHCCCCCCH	38.53	23403867
14	Phosphorylation	RSLGNQPSSEAAGRS HHCCCCCCHHHHCCC	30.92	23403867
15	Phosphorylation	SLGNQPSSEAAGRSE HCCCCCCHHHHCCCC	37.63	23403867
35	Phosphorylation	DPRGLQSSVYESRRV CCCCHHHHHHHHHCC	18.76	30622161
37	Phosphorylation	RGLQSSVYESRRVTD CCHHHHHHHHHCCCC	15.33	30622161
39	Phosphorylation	LQSSVYESRRVTDPE HHHHHHHHHCCCCHH	14.01	30622161
85	Phosphorylation	LDPKEALSELERVLD CCHHHHHHHHHHHHC	47.38	30622161
103	Phosphorylation	EEDIPEISRLSISQK HHCCHHHHHCCHHHC	26.05	30622161
106	Phosphorylation	IPEISRLSISQKLPS CHHHHHCCHHHCCCC	21.05	30622161
108	Phosphorylation	EISRLSISQKLPSTT HHHHCCHHHCCCCCH	20.20	30622161
110	Acetylation	SRLSISQKLPSTTMT HHCCHHHCCCCCHHH	56.42	7704565
113	Phosphorylation	SISQKLPSTTMTKAR CHHHCCCCCHHHHHH	47.12	-
114	Phosphorylation	ISQKLPSTTMTKARK HHHCCCCCHHHHHHH	20.74	-
115	Phosphorylation	SQKLPSTTMTKARKR HHCCCCCHHHHHHHH	27.47	-
121	Acetylation	TTMTKARKRRRRRRL CHHHHHHHHHHHHHH	55.93	7704573
135	Methylation	LMELAEPKINWQVLK HHHHHCCCCCHHHHC	39.93	-
135	"N6,N6-dimethyllysine"	LMELAEPKINWQVLK HHHHHCCCCCHHHHC	39.93	-
182	Phosphorylation	ERFLEDTTLTITVPA HHHHCCCEEEEEECH	33.94	-
207	Phosphorylation	PKRFYLEYYNNNRTT CCEEEEEECCCCCCC	14.65	29116813
208	Phosphorylation	KRFYLEYYNNNRTTP CEEEEEECCCCCCCC	11.31	29116813
265	Phosphorylation	AAQMAVPSSRILQLS HHHHHCCHHHHHHCC	26.17	28348404
266	Phosphorylation	AQMAVPSSRILQLSK HHHHCCHHHHHHCCC	19.78	28348404
272	Phosphorylation	SSRILQLSKPKAPAT HHHHHHCCCCCCCCC	33.67	24719451
295	Phosphorylation	PKPKPHVSDHNRLLH CCCCCCCCCHHHHHH	30.07	-
333	Phosphorylation	VTKKVVASPRIISLA HHHHHHCCHHHHHHC	11.78	30622161
338	Phosphorylation	VASPRIISLAKPKVR HCCHHHHHHCCHHHH	21.65	30622161
352	Phosphorylation	RKGLNEGYDRRPLAS HCCCCCCCCCCCCCC	10.49	28348404
359	Phosphorylation	YDRRPLASMSLPPPK CCCCCCCCCCCCCCC	19.31	26074081
361	Phosphorylation	RRPLASMSLPPPKAS CCCCCCCCCCCCCCC	34.92	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THEG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THEG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THEG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPE_HUMAN	CCT5	physical	10747865
MDFI_HUMAN	MDFI	physical	19060904

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.