AP5Z1_HUMAN - dbPTM
AP5Z1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP5Z1_HUMAN
UniProt AC O43299
Protein Name AP-5 complex subunit zeta-1
Gene Name AP5Z1
Organism Homo sapiens (Human).
Sequence Length 807
Subcellular Localization Cytoplasm . Nucleus . By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic.
Protein Description As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair..
Protein Sequence MFSAGAESLLHQAREIQDEELKKFCSRICKLLQAEDLGPDTLDSLQRLFLIISATKYSRRLEKTCVDLLQATLGLPACPEQLQVLCAAILREMSPSDSLSLAWDHTQNSRQLSLVASVLLAQGDRNEEVRAVGQGVLRALESRQPEGPSLRHLLPVMAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHSVLSSQFLALCTLKPSLVVELARDLLEFLGSVNGLCSRASLVTSVVWAIGEYLSVTYDRRCTVEQINKFFEALEALLFEVTQCRPSAALPRCPPQVVTVLMTTLTKLASRSQDLIPRASLLLSKMRTLAHSPATSSTHSEEGAEAIRTRATELLTLLKMPSVAQFVLTPSTEVCSPRYHRDANTALPLALRTVSRLVEREAGLMPG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22UbiquitinationEIQDEELKKFCSRIC
HCCHHHHHHHHHHHH		47.2722505724
30UbiquitinationKFCSRICKLLQAEDL
HHHHHHHHHHCCHHH		50.2721906983
30 (in isoform 2)Ubiquitination-50.2721906983
56UbiquitinationFLIISATKYSRRLEK
HHHHHHHHHHHHHHH		40.73-
142PhosphorylationGVLRALESRQPEGPS
HHHHHHHHCCCCCCC		36.7527174698
149PhosphorylationSRQPEGPSLRHLLPV
HCCCCCCCHHHHHHH		49.2227174698
151DimethylationQPEGPSLRHLLPVMA
CCCCCCHHHHHHHHE		23.81-
159 (in isoform 3)Ubiquitination-19.9121906983
177PhosphorylationEDQATLLSKRLVDWL
HHHHHHHHHHHHHHH		20.8824719451
178UbiquitinationDQATLLSKRLVDWLR
HHHHHHHHHHHHHHH		50.1222505724
179DimethylationQATLLSKRLVDWLRY
HHHHHHHHHHHHHHH		36.25-
195 (in isoform 3)Ubiquitination-44.0821906983
202PhosphorylationHSGGFFSTPRARQPG
CCCCCCCCCCCCCCC		16.1928555341
204MethylationGGFFSTPRARQPGPV
CCCCCCCCCCCCCCC		42.35-
253PhosphorylationLRAWLLHSGPEGPGT
HHHHHHHCCCCCCCC		56.8928857561
260PhosphorylationSGPEGPGTLDTDDRS
CCCCCCCCCCCCCCC		25.2928857561
263PhosphorylationEGPGTLDTDDRSEQE
CCCCCCCCCCCCCCC		42.8028857561
267PhosphorylationTLDTDDRSEQEGSTL
CCCCCCCCCCCCCEE		51.1026657352
315UbiquitinationSNRRALRKGDSDLQK
HHHHHHHCCCHHHHH		68.8421906983
315 (in isoform 2)Ubiquitination-68.8421906983
351UbiquitinationYRSLSCLKALHGRVR
HHHHHHHHHHCCCCC		53.9121906983
351 (in isoform 2)Ubiquitination-53.9121906983
369UbiquitinationASVRVLLPLAHFFLS
HHHHHHHHHHHHHHH		24.2821963094
525UbiquitinationFQYLLRPKASGATER
HHHHHCCCCCCCCCC		49.0721963094
569UbiquitinationAFFSAVTQVADGSLI
HHHHHHHHHCCCCHH		23.0821987572
663PhosphorylationVTYDRRCTVEQINKF
CCCCCCCCHHHHHHH		25.8529978859
707UbiquitinationVLMTTLTKLASRSQD
HHHHHHHHHHHCCCC		45.2121906983
725UbiquitinationRASLLLSKMRTLAHS
HHHHHHHHHHHHHCC		32.1627667366
728PhosphorylationLLLSKMRTLAHSPAT
HHHHHHHHHHCCCCC		25.4623186163
732PhosphorylationKMRTLAHSPATSSTH
HHHHHHCCCCCCCCC		15.6023312004
735PhosphorylationTLAHSPATSSTHSEE
HHHCCCCCCCCCCHH		26.9623186163
736PhosphorylationLAHSPATSSTHSEEG
HHCCCCCCCCCCHHH		35.0321712546
737PhosphorylationAHSPATSSTHSEEGA
HCCCCCCCCCCHHHH		26.2825599653
738PhosphorylationHSPATSSTHSEEGAE
CCCCCCCCCCHHHHH		29.2325599653
741 (in isoform 1)Ubiquitination-53.5021906983
749PhosphorylationEGAEAIRTRATELLT
HHHHHHHHHHHHHHH		20.6728674151
756O-linked_GlycosylationTRATELLTLLKMPSV
HHHHHHHHHHHCCCC		42.5430379171
759UbiquitinationTELLTLLKMPSVAQF
HHHHHHHHCCCCCEE		52.45-
771PhosphorylationAQFVLTPSTEVCSPR
CEEEECCCCCCCCCC		31.7828348404
772PhosphorylationQFVLTPSTEVCSPRY
EEEECCCCCCCCCCC		33.3728348404
776PhosphorylationTPSTEVCSPRYHRDA
CCCCCCCCCCCCCCH		20.0025850435
1026 (in isoform 1)Ubiquitination-21906983
1062 (in isoform 1)Ubiquitination-21906983
1418 (in isoform 1)Ubiquitination-21906983
1436 (in isoform 1)Ubiquitination-21906983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP5Z1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP5Z1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP5Z1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AP5Z1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613647Spastic paraplegia 48, autosomal recessive (SPG48)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP5Z1_HUMAN

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Related Literatures of Post-Translational Modification

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