PAR11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR11_HUMAN
• UniProt AC: Q9NR21
• Protein Name: Poly [ADP-ribose] polymerase 11
• Gene Name: PARP11
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Subcellular Localization: Nucleus, nuclear pore complex . Colocalizes with NUP153 at nuclear pores.
• Protein Description: Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity. [PubMed: 25673562]
• Protein Sequence: MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EANPEMFHKAEELFS CCCHHHHHHHHHHHH	41.54	24719451
13	ADP-ribosylation	PEMFHKAEELFSKTT HHHHHHHHHHHHCCC	39.52	25043379
18	ADP-ribosylation	KAEELFSKTTNNEVD HHHHHHHCCCCCCCC	39.06	25043379
56	ADP-ribosylation	QPDTNSQCSVSSEDI CCCCCCCCCCCHHHH	6.70	25043379
72	ADP-ribosylation	KSFKTNPCGSISFTT HHCCCCCCCCEEEEC	28.10	25043379
76	Phosphorylation	TNPCGSISFTTSKFS CCCCCCEEEECCCEE	29.29	29496963
87	ADP-ribosylation	SKFSYKIDFAEMKQM CCEEEEEEHHHHHHC	3.56	25043379
90	Phosphorylation	SYKIDFAEMKQMNLT EEEEEHHHHHHCCCC	28.62	29900121
91	Phosphorylation	YKIDFAEMKQMNLTT EEEEHHHHHHCCCCC	45.61	29900121
268	"N6,N6-dimethyllysine"	HGVSLQQRHLFRTYK ECEEHHHHHHHHHHH	34.53	-
268	Methylation	HGVSLQQRHLFRTYK ECEEHHHHHHHHHHH	34.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GTPB3_HUMAN	GTPBP3	physical	16189514
LYSC_HUMAN	LYZ	physical	19615732
RN114_HUMAN	RNF114	physical	19615732
DCA11_HUMAN	DCAF11	physical	19615732
PCH2_HUMAN	TRIP13	physical	19060904
RN114_HUMAN	RNF114	physical	26186194
MK12_HUMAN	MAPK12	physical	26186194
RN166_HUMAN	RNF166	physical	26186194
PAR11_HUMAN	PARP11	physical	25673562
RN166_HUMAN	RNF166	physical	28514442
MK12_HUMAN	MAPK12	physical	28514442
RN114_HUMAN	RNF114	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.