WNT11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT11_HUMAN
• UniProt AC: O96014
• Protein Name: Protein Wnt-11
• Gene Name: WNT11
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters..
• Protein Sequence: MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	GIKWLALSKTPSALA CHHHHHCCCCCCCHH	28.95	-
40	N-linked_Glycosylation	TPSALALNQTQHCKQ CCCCHHHCCCHHHHH	36.93	UniProtKB CARBOHYD
90	N-linked_Glycosylation	AFADMRWNCSSIELA HHCCCCCCCCCCEEC	12.86	UniProtKB CARBOHYD
160	N-linked_Glycosylation	RWGGCADNLSYGLLM CCCCCCCCCCHHHHH	16.62	UniProtKB CARBOHYD
177	Acetylation	KFSDAPMKVKKTGSQ CCCCCCCEEECCCHH	50.25	7350201
194	Phosphorylation	KLMRLHNSEVGRQAL HHHHHCCHHHHHHHH	23.94	-
204	Phosphorylation	GRQALRASLEMKCKC HHHHHHHHHHHHCCC	20.59	-
215	O-palmitoleoylation	KCKCHGVSGSCSIRT HCCCCCCCCCCHHHH	29.58	-
241	Phosphorylation	AADLKTRYLSATKVV HHHHHHHHHHCCEEE	15.39	22461510
245	Phosphorylation	KTRYLSATKVVHRPM HHHHHHCCEEECCCC	22.46	22461510
300	N-linked_Glycosylation	GTQDRQCNKTSNGSD CCCCCCCCCCCCCCC	42.15	UniProtKB CARBOHYD
302	Phosphorylation	QDRQCNKTSNGSDSC CCCCCCCCCCCCCCC	17.27	24114839
303	Phosphorylation	DRQCNKTSNGSDSCD CCCCCCCCCCCCCCC	40.58	24114839
304	N-linked_Glycosylation	RQCNKTSNGSDSCDL CCCCCCCCCCCCCCE	60.25	UniProtKB CARBOHYD
306	Phosphorylation	CNKTSNGSDSCDLMC CCCCCCCCCCCCEEE	30.51	24114839
308	Phosphorylation	KTSNGSDSCDLMCCG CCCCCCCCCCEEECC	15.95	24114839
333	Phosphorylation	VERCHCKYHWCCYVT HHHCCCCEEEEEEEE	13.12	-
338	Phosphorylation	CKYHWCCYVTCRRCE CCEEEEEEEEECCCC	8.82	-
340	Phosphorylation	YHWCCYVTCRRCERT EEEEEEEEECCCCHH	3.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.