ATL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATL3_HUMAN
• UniProt AC: P82987
• Protein Name: ADAMTS-like protein 3
• Gene Name: ADAMTSL3
• Organism: Homo sapiens (Human).
• Sequence Length: 1691
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Sequence: MASWTSPWWVLIGMVFMHSPLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETPPAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSCQEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	O-linked_Glycosylation	GSFLEDTTGEQFLTY CCCCCCCCCCEEEEE	51.55	OGP
60	Phosphorylation	EQFLTYRYDDQTSRN CEEEEEEECCCCCCC	17.29	24732914
64	Phosphorylation	TYRYDDQTSRNTRSD EEEECCCCCCCCCCC	36.33	24732914
70	Phosphorylation	QTSRNTRSDEDKDGN CCCCCCCCCCCCCCC	43.23	30576142
85	Phosphorylation	WDAWGDWSDCSRTCG CCCCCCHHHHCCCCC	33.22	30576142
88	Phosphorylation	WGDWSDCSRTCGGGA CCCHHHHCCCCCCCH	35.30	30576142
98	Phosphorylation	CGGGASYSLRRCLTG CCCCHHHCHHHHHCC	16.95	24719451
293	N-linked_Glycosylation	PGVFLVENTTVEFQR CCEEEEECCEEEEEC	33.30	UniProtKB CARBOHYD
302	Phosphorylation	TVEFQRGSERQTFKI EEEEECCCCCEEEEC	31.62	50563567
382	Phosphorylation	VPDHYCHYYPENVKP CCCCCCCCCCCCCCC	19.70	22817900
616	Phosphorylation	CEGPKLPTERPCLLE CCCCCCCCCCCCHHH	55.87	27251275
628	Phosphorylation	LLEACDESPASRELD HHHHCCCCCCCCCCC	16.71	24719451
631	Phosphorylation	ACDESPASRELDIPL HCCCCCCCCCCCCCC	29.67	29759185
681	N-linked_Glycosylation	IQTQQTVNDSLCDMV ECCCCCCCHHHHHHH	36.22	UniProtKB CARBOHYD
797	N-linked_Glycosylation	LTDGSFLNLSDELCQ CCCCCCCCCCHHHHC	35.17	UniProtKB CARBOHYD
829	Phosphorylation	HLAVGDWSKCSVSCG CEECCCHHHCCCCCC	28.64	113312417
905	Phosphorylation	ILSVQRVYIQTREEK EEEEEEEEEECCCCC	6.90	153737
915	N-linked_Glycosylation	TREEKRINLTIGSRA CCCCCCCCEEECCCE	34.85	UniProtKB CARBOHYD
927	N-linked_Glycosylation	SRAYLLPNTSVIIKC CCEEECCCCEEEEEE	44.98	UniProtKB CARBOHYD
1102	N-linked_Glycosylation	QFDELIRNMSQLMET HHHHHHHHHHHHHHH	27.71	UniProtKB CARBOHYD
1104	Phosphorylation	DELIRNMSQLMETGE HHHHHHHHHHHHHCC	24.58	23663014
1109	Phosphorylation	NMSQLMETGEVSDDL HHHHHHHHCCCCHHH	25.36	23663014
1113	Phosphorylation	LMETGEVSDDLASQL HHHHCCCCHHHHHHH	22.54	23663014
1118	Phosphorylation	EVSDDLASQLIYQLV CCCHHHHHHHHHHHH	32.58	23663014
1122	Phosphorylation	DLASQLIYQLVAELA HHHHHHHHHHHHHHH	12.37	23663014
1183	Phosphorylation	GPVLMRQSQPPSISF CCEEEECCCCCCCCC	34.00	23663014
1187	Phosphorylation	MRQSQPPSISFNKTI EECCCCCCCCCCCCH	37.23	23663014
1187	O-linked_Glycosylation	MRQSQPPSISFNKTI EECCCCCCCCCCCCH	37.23	29351928
1189	O-linked_Glycosylation	QSQPPSISFNKTINS CCCCCCCCCCCCHHC	27.40	29351928
1189	Phosphorylation	QSQPPSISFNKTINS CCCCCCCCCCCCHHC	27.40	46159463
1191	N-linked_Glycosylation	QPPSISFNKTINSRI CCCCCCCCCCHHCCC	33.50	UniProtKB CARBOHYD
1288	Phosphorylation	AEAPVILSVERNITK EECCEEEEEECCCCC	15.71	24719451
1292	N-linked_Glycosylation	VILSVERNITKPEHN EEEEEECCCCCCCCC	32.54	UniProtKB CARBOHYD
1316	N-linked_Glycosylation	VEAALGANVTIRCPV HHHHCCCCEEEECCC	29.66	UniProtKB CARBOHYD
1330	N-linked_Glycosylation	VKGVPQPNITWLKRG CCCCCCCCEEEEECC	38.79	UniProtKB CARBOHYD
1343	N-linked_Glycosylation	RGGSLSGNVSLLFNG CCCCCCCCEEEEECC	19.48	UniProtKB CARBOHYD
1349	N-linked_Glycosylation	GNVSLLFNGSLLLQN CCEEEEECCCEEEEE	38.83	UniProtKB CARBOHYD
1356	N-linked_Glycosylation	NGSLLLQNVSLENEG CCCEEEEEEECCCCC	25.89	UniProtKB CARBOHYD
1379	Phosphorylation	ALGKAVATSVLHLLE HHHHHHHHHHHHHHH	16.87	24505115
1380	Phosphorylation	LGKAVATSVLHLLER HHHHHHHHHHHHHHH	16.97	24505115
1403	Phosphorylation	FLQGHKKYILQATNT EEECCCEEEEEECCC	16.21	8227265
1432	N-linked_Glycosylation	EPFWEPGNWSHCSAT CCCCCCCCCCHHHCC	48.03	UniProtKB CARBOHYD
1516	N-linked_Glycosylation	TCKRTKANGTVQVVS EEEEECCCCEEEEEC	48.50	UniProtKB CARBOHYD
1518	Phosphorylation	KRTKANGTVQVVSPR EEECCCCEEEEECCC	13.94	21712546
1523	Phosphorylation	NGTVQVVSPRACAPK CCEEEEECCCCCCCC	15.15	21712546
1574	N-linked_Glycosylation	RHTACQHNSSDSNCD HHCCCCCCCCCCCCC	19.82	UniProtKB CARBOHYD
1591	N-linked_Glycosylation	KRPTLRRNCTSGACD CCCCHHHHCCCCCCC	27.30	UniProtKB CARBOHYD
1646	Phosphorylation	VQKKKPISWRHCLGP CCCCCCCCCHHCCCC	26.95	24719451
1671 (in isoform 2)	Phosphorylation	-	18.04	22210691
1682 (in isoform 2)	Phosphorylation	-	34.41	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRA23_HUMAN	KRTAP2-4	physical	25416956
KRA24_HUMAN	KRTAP2-4	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.