| UniProt ID | TINAL_HUMAN | |
|---|---|---|
| UniProt AC | Q9GZM7 | |
| Protein Name | Tubulointerstitial nephritis antigen-like | |
| Gene Name | TINAGL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 467 | |
| Subcellular Localization | Secreted . | |
| Protein Description | May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).. | |
| Protein Sequence | MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 78 | N-linked_Glycosylation | CYCDLFCNRTVSDCC HHHHHHCCCCHHHHC | 35.01 | 19159218 | |
| 161 | N-linked_Glycosylation | NYGWQAGNHSAFWGM CCCEECCCCCCCCCC | 29.02 | 19159218 | |
| 387 | Phosphorylation | IYSHTPVSLGRPERY EECCCCCCCCCCHHH | 26.72 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TINAL_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TINAL_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TINAL_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MED31_HUMAN | MED31 | physical | 16169070 | |
| UT14A_HUMAN | UTP14A | physical | 16169070 | |
| KRA42_HUMAN | KRTAP4-2 | physical | 25416956 | |
| KR122_HUMAN | KRTAP12-2 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| ANM5_HUMAN | PRMT5 | physical | 26186194 | |
| GBB2_HUMAN | GNB2 | physical | 26186194 | |
| CD59_HUMAN | CD59 | physical | 26186194 | |
| RIOK1_HUMAN | RIOK1 | physical | 26186194 | |
| PGBM_HUMAN | HSPG2 | physical | 26186194 | |
| LOXL2_HUMAN | LOXL2 | physical | 26186194 | |
| PGBM_HUMAN | HSPG2 | physical | 28514442 | |
| RIOK1_HUMAN | RIOK1 | physical | 28514442 | |
| ANM5_HUMAN | PRMT5 | physical | 28514442 | |
| CD59_HUMAN | CD59 | physical | 28514442 | |
| LOXL2_HUMAN | LOXL2 | physical | 28514442 | |
| GBB2_HUMAN | GNB2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78 AND ASN-161, AND MASSSPECTROMETRY. | |
