GRIN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIN2_HUMAN
• UniProt AC: O60269
• Protein Name: G protein-regulated inducer of neurite outgrowth 2
• Gene Name: GPRIN2
• Organism: Homo sapiens (Human).
• Sequence Length: 458
• Protein Description: May be involved in neurite outgrowth..
• Protein Sequence: MSSSRPEPGPWAPLSPRLQPLSQSSSSLLGEGREQRPELRKTASSTVWQAQLGEASTRPQAPEEEGNPPESMKPARASGPKARPSAGGHWWSSTVGNVSTMGGSDLCRLRAPSAAAMQRSHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGGTSGQGGQAPAGLERDLAPEDETSNSAWMLGASQLSVPPLDLGDTTAHSSSAQAEPKAAEQLATTTCHALPPAALLCGMREVRAGGCCHALPATGILAFPKLVASVSESGLQAQHGVKIHCRLSGGLPGHSHCCAHLWGPAGLVPEPGSRTKDVWTMTSANDLAPAEASPLSAQDAGVQAAPVAACKAVATSPSLEAPAALHVFPEVTLGSSLEEVPSPVRDVRWDAEGMTWEVYGAAVDLEVLGVAIQKHLEMQFEQLQRAPASEDSLSVEGRRGPLRAVMQSLRRPSCCGCSGAAPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PGPWAPLSPRLQPLS CCCCCCCCCCCCCCC	13.60	24719451
22	Phosphorylation	SPRLQPLSQSSSSLL CCCCCCCCCCHHHHC	34.40	25219547
24	Phosphorylation	RLQPLSQSSSSLLGE CCCCCCCCHHHHCCC	28.89	25219547
25	Phosphorylation	LQPLSQSSSSLLGEG CCCCCCCHHHHCCCC	19.13	25219547
26	Phosphorylation	QPLSQSSSSLLGEGR CCCCCCHHHHCCCCH	30.19	25219547
27	Phosphorylation	PLSQSSSSLLGEGRE CCCCCHHHHCCCCHH	29.57	25219547
92	Phosphorylation	SAGGHWWSSTVGNVS CCCCCCCCCCCCCCC	15.79	30576142
94	Phosphorylation	GGHWWSSTVGNVSTM CCCCCCCCCCCCCCC	27.24	30576142
99	Phosphorylation	SSTVGNVSTMGGSDL CCCCCCCCCCCCCHH	19.37	30576142
119	Methylation	PSAAAMQRSHSDLVR CCHHHHHHCHHHHHH	24.21	-
120	Phosphorylation	SAAAMQRSHSDLVRS CHHHHHHCHHHHHHH	15.51	23312004
122	Phosphorylation	AAMQRSHSDLVRSTQ HHHHHCHHHHHHHHH	33.61	29496963
126	Methylation	RSHSDLVRSTQMRGH HCHHHHHHHHHHCCC	41.08	-
140	Phosphorylation	HSGARKASLSCSALG CCCCCCCCCCCHHCC	24.69	23663014
142	Phosphorylation	GARKASLSCSALGSS CCCCCCCCCHHCCCC	11.97	23663014
144	Phosphorylation	RKASLSCSALGSSPV CCCCCCCHHCCCCCC	24.13	23663014
148	Phosphorylation	LSCSALGSSPVHRAQ CCCHHCCCCCCEEEE	32.11	23663014
149	Phosphorylation	SCSALGSSPVHRAQL CCHHCCCCCCEEEEC	29.19	23663014
182	Phosphorylation	DLAPEDETSNSAWML CCCCCCCCCCCCCCC	45.59	28111955
183	Phosphorylation	LAPEDETSNSAWMLG CCCCCCCCCCCCCCC	27.09	28111955
185	Phosphorylation	PEDETSNSAWMLGAS CCCCCCCCCCCCCCC	24.07	28111955
192	Phosphorylation	SAWMLGASQLSVPPL CCCCCCCCCCCCCCC	29.83	28111955
195	Phosphorylation	MLGASQLSVPPLDLG CCCCCCCCCCCCCCC	25.58	28111955
204	Phosphorylation	PPLDLGDTTAHSSSA CCCCCCCCCCCCCCC	24.88	28111955
205	Phosphorylation	PLDLGDTTAHSSSAQ CCCCCCCCCCCCCCC	27.41	28111955
208	Phosphorylation	LGDTTAHSSSAQAEP CCCCCCCCCCCCCCH	24.43	28111955
209	Phosphorylation	GDTTAHSSSAQAEPK CCCCCCCCCCCCCHH	21.59	28111955
210	Phosphorylation	DTTAHSSSAQAEPKA CCCCCCCCCCCCHHH	27.67	28111955
264	Phosphorylation	AFPKLVASVSESGLQ HHHHHHEEECHHHCH	20.78	23312004
266	Phosphorylation	PKLVASVSESGLQAQ HHHHEEECHHHCHHH	24.45	28857561
268	Phosphorylation	LVASVSESGLQAQHG HHEEECHHHCHHHCC	36.98	23312004
283	Phosphorylation	VKIHCRLSGGLPGHS EEEEEEECCCCCCCC	16.09	28348404
290	Phosphorylation	SGGLPGHSHCCAHLW CCCCCCCCCCCHHHH	24.92	28348404
424	Phosphorylation	QLQRAPASEDSLSVE HHHHCCCCCCCCCCC	40.66	23663014
427	Phosphorylation	RAPASEDSLSVEGRR HCCCCCCCCCCCCCC	20.63	23663014
429	Phosphorylation	PASEDSLSVEGRRGP CCCCCCCCCCCCCCH	23.29	23663014
448	Phosphorylation	MQSLRRPSCCGCSGA HHHCCCCCCCCCCCC	21.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPY2_HUMAN	SPRY2	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
DYL2_HUMAN	DYNLL2	physical	16189514
BAP31_HUMAN	BCAP31	physical	25416956
DYL2_HUMAN	DYNLL2	physical	25416956
KR121_HUMAN	KRTAP12-1	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.