FZD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD9_HUMAN
• UniProt AC: O00144
• Protein Name: Frizzled-9
• Gene Name: FZD9
• Organism: Homo sapiens (Human).
• Sequence Length: 591
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane.
• Protein Description: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. [PubMed: 27509850 During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity]
• Protein Sequence: MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	MCRGIGYNLTRMPNL CCCCCCCCCCCCCCC	29.71	UniProtKB CARBOHYD
158	N-linked_Glycosylation	LCMEAPENATAGPAE CCCCCCCCCCCCCCC	41.34	UniProtKB CARBOHYD
204	Phosphorylation	ENPEKFQYVEKSRSC CCHHHHHEEEHHCCC	17.44	27259358
375	Phosphorylation	LKTIVILTLRKVAGD HHHHHHHHHHHHHCC	17.25	24114839
553	Ubiquitination	AAGRARAKACRAPGS HHHHHHHHHCCCCCC	42.33	-
569	Phosphorylation	GRGTHCHYKAPTVVL CCCCCCCCCCCEEEE	17.78	-
579	Phosphorylation	PTVVLHMTKTDPSLE CEEEEEEECCCCCCC	21.75	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.