| UniProt ID | XKR8_HUMAN | |
|---|---|---|
| UniProt AC | Q9H6D3 | |
| Protein Name | XK-related protein 8 | |
| Gene Name | XKR8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 395 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.. | |
| Protein Sequence | MPWSSRGALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQELRQGLLVWQQEEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYYQWVGICTSFLGISWALLDYHRALRTCLPSKPLLGLGSSVIYFLWNLLLLWPRVLAVALFSALFPSYVALHFLGLWLVLLLWVWLQGTDFMPDPSSEWLYRVTVATILYFSWFNVAEGRTRGRAIIHFAFLLSDSILLVATWVTHSSWLPSGIPLQLWLPVGCGCFFLGLALRLVYYHWLHPSCCWKPDPDQVDGARSLLSPEGYQLPQNRRMTHLAQKFFPKAKDEAASPVKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 191 | Phosphorylation | ALRTCLPSKPLLGLG HHHHHCCCCCCCCCC | 33.68 | 24719451 | |
| 264 | Phosphorylation | SEWLYRVTVATILYF CHHHHHHHHHHHHHH | 8.74 | 18452278 | |
| 267 | Phosphorylation | LYRVTVATILYFSWF HHHHHHHHHHHHHHH | 13.74 | 19690332 | |
| 270 | Phosphorylation | VTVATILYFSWFNVA HHHHHHHHHHHHCCC | 7.54 | 19690332 | |
| 272 | Phosphorylation | VATILYFSWFNVAEG HHHHHHHHHHCCCCC | 19.73 | 18452278 | |
| 359 | Phosphorylation | DQVDGARSLLSPEGY HHCCCCHHHCCCCCC | 32.88 | 28796482 | |
| 362 | Phosphorylation | DGARSLLSPEGYQLP CCCHHHCCCCCCCCC | 26.63 | 28796482 | |
| 366 | Phosphorylation | SLLSPEGYQLPQNRR HHCCCCCCCCCCCHH | 12.76 | 28796482 | |
| 391 | Phosphorylation | KAKDEAASPVKG--- HHHHHCCCCCCC--- | 36.96 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XKR8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XKR8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XKR8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of XKR8_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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