dbPTM

GGT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GGT6_HUMAN
UniProt AC	Q6P531
Protein Name	Glutathione hydrolase 6
Gene Name	GGT6
Organism	Homo sapiens (Human).
Sequence Length	493
Subcellular Localization	Membrane Single-pass type II membrane protein.
Protein Description	Cleaves glutathione conjugates..
Protein Sequence	MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQDSSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGPGVYHHGAIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDSSSGNSTALTSGPAQTLAPGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLLCHADGTPLGAGARATNPQLAAVLRSAALAPTSDLAGDALLSLLAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSNLVAKSTTSAWACPLILRGSLDDTEADVLGLVASGTPDVARAMTHTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHVSSVPHACCPFQGF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RAEEPVVYQKLLPWE CCCCCCCHHCCCCCC	10.52	-
19	Phosphorylation	KLLPWEPSLESEEEV CCCCCCCCCCCHHHH	33.00	28102081
22	Phosphorylation	PWEPSLESEEEVEEE CCCCCCCCHHHHCHH	56.45	28102081
31	Phosphorylation	EEVEEEETSEALVLN HHHCHHHHCCCEECC	34.84	28102081
32	Phosphorylation	EVEEEETSEALVLNP HHCHHHHCCCEECCC	24.93	28102081
161	N-linked_Glycosylation	FHDSSSGNSTALTSG HCCCCCCCCCCCCCC	37.83	UniProtKB CARBOHYD
370	N-linked_Glycosylation	LLLTSSLNCSFGSAH EEEECCCCCCCCCCC	22.72	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GGT6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GGT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GGT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GGT6_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GGT6_HUMAN

Related Literatures of Post-Translational Modification