FXL20_HUMAN - dbPTM
FXL20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FXL20_HUMAN
UniProt AC Q96IG2
Protein Name F-box/LRR-repeat protein 20
Gene Name FBXL20
Organism Homo sapiens (Human).
Sequence Length 436
Subcellular Localization Cytoplasm.
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)..
Protein Sequence MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationRRDVNGVTKSRFEMF
CCCCCCCCHHHHHHC		25.3830622161
10UbiquitinationRDVNGVTKSRFEMFS
CCCCCCCHHHHHHCC		36.9129967540
87UbiquitinationRVVENISKRCGGFLR
CHHHHHHHHCCHHHH		48.16-
97PhosphorylationGGFLRKLSLRGCLGV
CHHHHHCHHCCCCCC		21.0317322306
129UbiquitinationLNLNGCTKTTDATCT
EECCCCCCCCCCCHH		54.2032015554
130PhosphorylationNLNGCTKTTDATCTS
ECCCCCCCCCCCHHH		16.2626552605
131PhosphorylationLNGCTKTTDATCTSL
CCCCCCCCCCCHHHH		25.7826552605
134PhosphorylationCTKTTDATCTSLSKF
CCCCCCCCHHHHHHH		21.0826552605
136PhosphorylationKTTDATCTSLSKFCS
CCCCCCHHHHHHHHH		28.4826552605
137PhosphorylationTTDATCTSLSKFCSK
CCCCCHHHHHHHHHH		32.5626552605
139PhosphorylationDATCTSLSKFCSKLR
CCCHHHHHHHHHHCC		24.3726552605
140UbiquitinationATCTSLSKFCSKLRH
CCHHHHHHHHHHCCC		56.5429967540
166UbiquitinationMSLKALSEGCPLLEQ
HHHHHHHCCCCHHHH		66.7123000965
171UbiquitinationLSEGCPLLEQLNISW
HHCCCCHHHHCCCCC		2.0823000965
198UbiquitinationVRGCGGLKALFLKGC
HHHCCHHHHHHHCCC		46.4423000965
203UbiquitinationGLKALFLKGCTQLED
HHHHHHHCCCCCCHH		44.6023000965
208UbiquitinationFLKGCTQLEDEALKY
HHCCCCCCHHHHHHH		4.8923000965
235UbiquitinationLQTCLQITDEGLITI
HHHHCCCCCCHHHHH		18.2923000965
240UbiquitinationQITDEGLITICRGCH
CCCCCHHHHHCHHHH		3.4323000965
287PhosphorylationVARCSQLTDVGFTTL
HHCHHHCCCCCHHHH		22.4722210691
385PhosphorylationCHSLERIELYDCQQI
CCCCCEEEEECHHHH		47.7232645325
389PhosphorylationERIELYDCQQITRAG
CEEEEECHHHHHHHH		1.7132142685
412PhosphorylationPNIKVHAYFAPVTPP
CCCEEEEEECCCCCC		5.8430266825
417PhosphorylationHAYFAPVTPPPSVGG
EEEECCCCCCCCCCC		29.0829255136
421PhosphorylationAPVTPPPSVGGSRQR
CCCCCCCCCCCCCCC		38.8923927012
422PhosphorylationPVTPPPSVGGSRQRF
CCCCCCCCCCCCCCE		14.3632645325
425PhosphorylationPPPSVGGSRQRFCRC
CCCCCCCCCCCEEEE		21.2230266825
426PhosphorylationPPSVGGSRQRFCRCC
CCCCCCCCCCEEEEE		34.6632142685
454Phosphorylation-------------------------
-------------------------		32645325
458Phosphorylation-----------------------------
-----------------------------		32142685
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FXL20_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FXL20_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FXL20_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FXL20_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FXL20_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, AND MASSSPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, AND MASSSPECTROMETRY.

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