NRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRF1_HUMAN
• UniProt AC: Q16656
• Protein Name: Nuclear respiratory factor 1
• Gene Name: NRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication..
• Protein Sequence: MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	YTEHSMLSADEDSPS ECCCCCCCCCCCCCC	25.65	9228045
44	Phosphorylation	MLSADEDSPSSPEDT CCCCCCCCCCCCCCC	25.32	9228045
46	Phosphorylation	SADEDSPSSPEDTSY CCCCCCCCCCCCCCC	63.58	9228045
47	Phosphorylation	ADEDSPSSPEDTSYD CCCCCCCCCCCCCCC	35.38	9228045
52	Phosphorylation	PSSPEDTSYDDSDIL CCCCCCCCCCHHHHC	38.60	28112733
53	Ubiquitination	SSPEDTSYDDSDILN CCCCCCCCCHHHHCC	26.34	-
87	Phosphorylation	AAAAAVATGKKRKRP HHHHHHHCCCCCCCC	42.82	-
92	Ubiquitination	VATGKKRKRPHVFES HHCCCCCCCCCCCCC	78.24	-
99	Phosphorylation	KRPHVFESNPSIRKR CCCCCCCCCHHHHHH	42.44	28555341
102	Phosphorylation	HVFESNPSIRKRQQT CCCCCCHHHHHHHHH	39.00	29214152
106	Ubiquitination	SNPSIRKRQQTRLLR CCHHHHHHHHHHHHH	24.80	-
118	Phosphorylation	LLRKLRATLDEYTTR HHHHHHHHHHHHHHH	28.45	-
122	Phosphorylation	LRATLDEYTTRVGQQ HHHHHHHHHHHHCCE	17.05	-
123	Phosphorylation	RATLDEYTTRVGQQA HHHHHHHHHHHCCEE	13.18	-
136	Phosphorylation	QAIVLCISPSKPNPV EEEEEEECCCCCCCC	23.32	29255136
138	Phosphorylation	IVLCISPSKPNPVFK EEEEECCCCCCCCCE	54.69	29255136
139	Sumoylation	VLCISPSKPNPVFKV EEEECCCCCCCCCEE	52.80	28112733
139	Acetylation	VLCISPSKPNPVFKV EEEECCCCCCCCCEE	52.80	26051181
139	Ubiquitination	VLCISPSKPNPVFKV EEEECCCCCCCCCEE	52.80	-
139	Ubiquitination	VLCISPSKPNPVFKV EEEECCCCCCCCCEE	52.80	-
201	Phosphorylation	PVSVDKMTQAQLRAF ECCCCCCCHHHHHHH	26.88	-
214	Ubiquitination	AFIPEMLKYSTGRGK HHHHHHHHHCCCCCC	35.53	-
214	Ubiquitination	AFIPEMLKYSTGRGK HHHHHHHHHCCCCCC	35.53	-
221	Acetylation	KYSTGRGKPGWGKES HHCCCCCCCCCCCCC	38.71	18527249
226	Acetylation	RGKPGWGKESCKPIW CCCCCCCCCCCCCCC	39.69	18527257
259	Phosphorylation	QKQRVSWTQALRTIV HHHHCHHHHHHHHHH	9.10	-
267	Ubiquitination	QALRTIVKNCYKQHG HHHHHHHHHHHHHHC	37.13	-
267	Ubiquitination	QALRTIVKNCYKQHG HHHHHHHHHHHHHHC	37.13	-
287	Phosphorylation	YAFEDQQTQTQATAT EEEECCCCCHHHHHH	28.13	-
294	O-linked_Glycosylation	TQTQATATHSIAHLV CCHHHHHHHHHHHHC	16.29	23301498
296	O-linked_Glycosylation	TQATATHSIAHLVPS HHHHHHHHHHHHCCC	19.67	23301498
303	O-linked_Glycosylation	SIAHLVPSQTVVQTF HHHHHCCCCEEEEEE	30.88	23301498
369	O-linked_Glycosylation	TLQGGEMTIQTTQAS EEECCEEEEEECCHH	12.96	23301498
432	O-linked_Glycosylation	GGGQIVLSGETAAAV CCCEEEECCCHHHHH	24.56	23301498
443	O-linked_Glycosylation	AAAVGALTGVQDANG HHHHHHHHCCCCCCC	34.47	23301498
457	O-linked_Glycosylation	GLVQIPVSMYQTVVT CCEEEEHHHHHHHHH	13.35	23301498
487	Phosphorylation	VTTRISDSAVTMDGQ CCCEECCCEEEECCE	20.18	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
39	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
39	S	Phosphorylation	Kinase	CK2	-	Uniprot
44	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
44	S	Phosphorylation	Kinase	CK2	-	Uniprot
46	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
46	S	Phosphorylation	Kinase	CK2	-	Uniprot
47	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
47	S	Phosphorylation	Kinase	CK2	-	Uniprot
52	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
52	S	Phosphorylation	Kinase	CK2	-	Uniprot
201	T	Phosphorylation	Kinase	ATM	Q13315	PSP
259	T	Phosphorylation	Kinase	ATM	Q13315	PSP
287	T	Phosphorylation	Kinase	ATM	Q13315	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:21911472

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL1_MOUSE	Dynll1	physical	11069771
DYLT1_MOUSE	Dynlt1b	physical	11069771
DYL1_HUMAN	DYNLL1	physical	11069771
PRGC1_HUMAN	PPARGC1A	physical	10412986
PARP1_HUMAN	PARP1	physical	19181665
CEBPB_HUMAN	CEBPB	physical	15308669
CSK21_HUMAN	CSNK2A1	physical	23816881
CSK2B_HUMAN	CSNK2B	physical	23816881
SP4_HUMAN	SP4	physical	25416956
TRAF2_HUMAN	TRAF2	physical	25416956
POGZ_HUMAN	POGZ	physical	25416956
PLDX1_HUMAN	PLXDC1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.