PLDX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLDX1_HUMAN
• UniProt AC: Q8IUK5
• Protein Name: Plexin domain-containing protein 1
• Gene Name: PLXDC1
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; I
• Protein Description: Plays a critical role in endothelial cell capillary morphogenesis..
• Protein Sequence: MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	WNRRARESPGHVSEP CCCCCCCCCCCCCCC	30.54	25690035
61	Phosphorylation	HVSEPDRTQLSQDLG CCCCCCCHHCCCCCC	41.04	18491316
64	Phosphorylation	EPDRTQLSQDLGGGT CCCCHHCCCCCCCCE	16.30	18491316
80	N-linked_Glycosylation	AMDTLPDNRTRVVED EECCCCCCCEEEEEC	45.33	UniProtKB CARBOHYD
197	N-linked_Glycosylation	STVVYFDNGTVFVVQ CEEEEECCCEEEEEE	37.83	UniProtKB CARBOHYD
241	Phosphorylation	AYKEIPMSVPEISSS EEEECCCCCCCCCCC	29.21	-
258 (in isoform 4)	Phosphorylation	-	49.20	27732954
266 (in isoform 4)	Phosphorylation	-	32.43	27732954
267 (in isoform 4)	Phosphorylation	-	48.12	27732954
273 (in isoform 4)	Phosphorylation	-	36.05	27732954
279 (in isoform 4)	Phosphorylation	-	38.47	27732954
280	Phosphorylation	RRRSIFEYHRIELDP HHHCHHEEEEEECCH	5.90	22817900
280 (in isoform 4)	Phosphorylation	-	5.90	27732954
282 (in isoform 4)	Phosphorylation	-	24.15	27732954
309	Phosphorylation	PTCLQHRSCDACMSS CCHHHCCCCCCCCCC	17.77	30576142
315	Phosphorylation	RSCDACMSSDLTFNC CCCCCCCCCCCEECC	22.15	30576142
331 (in isoform 2)	Phosphorylation	-	2.15	27732954
339 (in isoform 2)	Phosphorylation	-	28.92	27732954
340 (in isoform 2)	Phosphorylation	-	39.51	27732954
346 (in isoform 2)	Phosphorylation	-	8.95	27732954
352 (in isoform 2)	Phosphorylation	-	46.72	27732954
353 (in isoform 2)	Phosphorylation	-	29.66	27732954
355 (in isoform 2)	Phosphorylation	-	4.28	27732954
372	O-linked_Glycosylation	DSASPDTSFSPYDGD CCCCCCCCCCCCCCC	30.98	OGP
393	O-linked_Glycosylation	SLFIDSLTTEDDTKL EEEEECCCCCCCCCC	31.90	OGP
403	Phosphorylation	DDTKLNPYAGGDGLQ CCCCCCCCCCCCCCC	19.46	-
471	Ubiquitination	PHHWPAMKFRSHPDH CCCCCCCCEECCCCC	39.47	21890473
481	Phosphorylation	SHPDHSTYAEVEPSG CCCCCCCEEEECCCC	12.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLDX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLDX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLDX1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLDX1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.