| UniProt ID | RN112_MOUSE | |
|---|---|---|
| UniProt AC | Q96DY5 | |
| Protein Name | RING finger protein 112 | |
| Gene Name | Rnf112 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 654 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . Membrane Peripheral membrane protein . Cytoplasm . Nucleus . Nucleus, Nuclear body . Nucleus, nucleoplasm . Endosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse, postsynapt |
|
| Protein Description | E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. [PubMed: 21566658] | |
| Protein Sequence | MPRPVLSVTAFCHRLGKRESKRSFMGNSSNSWVLPREEAQGWMGQAVQGGTRTSRSHASFPKLELGLGHRPSPTREPPTCSICLERLREPISLDCGHDFCIRCFSTHRIPGCELPCCPECRKICKQRKGLRSLGERMKLLPQRPLPPALQETCAVRAERLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLSGLPSLESGDSGRPRAEGSLPGIRWGANGLTRGIWMWSHPFLLGKEGKKVAVFLVDTGDVMSPELSKETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHHNKSGQGHVGDILQKLSGKYPKVQELLLGKRARCYLLPAPERQWVNKDQASPRGNTEDDFSHHFRAYILDVLSTAPQHAKSRCQGYWSEGRAVARGDRRLLTGQQLAQEIKNLSGWMGKTGPSFNSPDEMAAQLHDLRKVEAAKKEFEEYVRQQDIATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKEREQTLEALEAELQAEAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERVQGGDREPLLQEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Phosphorylation | GQAVQGGTRTSRSHA CHHHCCCCCCCCCCC | 37.28 | - | |
| 290 | Phosphorylation | RVKLCALTMMLSSYQ HHHHHHHHHHHHHHH | 5.08 | 25777480 | |
| 294 | Phosphorylation | CALTMMLSSYQILNT HHHHHHHHHHHHHCC | 14.76 | 25777480 | |
| 295 | Phosphorylation | ALTMMLSSYQILNTS HHHHHHHHHHHHCCC | 19.66 | 25777480 | |
| 296 | Phosphorylation | LTMMLSSYQILNTSQ HHHHHHHHHHHCCCH | 9.01 | 25777480 | |
| 301 | Phosphorylation | SSYQILNTSQELKDT HHHHHHCCCHHHCCC | 28.48 | 25777480 | |
| 302 | Phosphorylation | SYQILNTSQELKDTD HHHHHCCCHHHCCCC | 22.15 | 25777480 | |
| 344 (in isoform 3) | Phosphorylation | - | 32.27 | 29514104 | |
| 347 (in isoform 3) | Phosphorylation | - | 52.16 | 29514104 | |
| 395 | Phosphorylation | WVNKDQASPRGNTED CCCCCCCCCCCCCCC | 14.97 | 29899451 | |
| 400 | Phosphorylation | QASPRGNTEDDFSHH CCCCCCCCCCHHHHH | 43.55 | 29899451 | |
| 524 | Ubiquitination | RNLLSTQKDAILARH HHHHHHHHHHHHHHH | 49.57 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RN112_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RN112_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RN112_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZBT16_HUMAN | ZBTB16 | physical | 24359566 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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