NALP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NALP7_HUMAN
• UniProt AC: Q8WX94
• Protein Name: NACHT, LRR and PYD domains-containing protein 7
• Gene Name: NLRP7
• Organism: Homo sapiens (Human).
• Sequence Length: 980
• Protein Description: Inhibits CASP1/caspase-1-dependent IL1B secretion..
• Protein Sequence: MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSPQLEWT ------CCCHHHHHH	49.46	-
3	Phosphorylation	-----MTSPQLEWTL -----CCCHHHHHHH	14.89	-
24	Phosphorylation	LNEDELKSFKSLLWA CCHHHHHHHHHHHHH	51.00	24719451
61	Phosphorylation	LAEILVNTSSENWIR HHHHHHCCCCCHHHH	26.59	-
81	Phosphorylation	ILEEMNLTELCKMAK HHHHCCHHHHHHHHH	23.16	-
151	Phosphorylation	DNFHDDVTLRNQRFI CCCCCCCCCCCCCCC	27.31	24719451
189	Acetylation	VGKTTLAKKCMLDWT CCHHHHCHHHCCCCC	50.01	30590777
196	Phosphorylation	KKCMLDWTDCNLSPT HHHCCCCCCCCCCHH	30.27	26434552
209	Phosphorylation	PTLRYAFYLSCKELS HHHHHHHHHHHHHHH	6.91	26434552
211	Phosphorylation	LRYAFYLSCKELSRM HHHHHHHHHHHHHHH	16.27	26434552
285	Phosphorylation	PVPVLLGSLLKRKML CCCCHHHHHHHCCCC	30.42	24719451
288	Ubiquitination	VLLGSLLKRKMLPRA CHHHHHHHCCCCCCH	56.09	-
318	Phosphorylation	LLAQQPIYVRVEGFL HHHHCCEEEEEEECC	6.73	-
414	Phosphorylation	QLRGALRTLSLLAAQ HHHHHHHHHHHHHHC	22.88	24043423
416	Phosphorylation	RGALRTLSLLAAQGL HHHHHHHHHHHHCCH	22.26	24043423
443	Phosphorylation	ERLGVQESDLRLFLD HHHCCCHHHEEHEEC	25.50	24905233
460	Phosphorylation	ILRQDRVSKGCYSFI HHCCCCCCCCCHHHH	24.99	-
505	Phosphorylation	GDVQKLLSGEERLKN HHHHHHHCCHHHHCC	55.37	26091039
529	Ubiquitination	LFGLANEKRAKELEA HHHHCCHHHHHHHHH	58.42	22817900
532 (in isoform 2)	Ubiquitination	-	67.85	21906983
532	Ubiquitination	LANEKRAKELEATFG HCCHHHHHHHHHHHC	67.85	21906983
532 (in isoform 1)	Ubiquitination	-	67.85	21906983
537	Phosphorylation	RAKELEATFGCRMSP HHHHHHHHHCCCCCH	15.93	29514088
543	Phosphorylation	ATFGCRMSPDIKQEL HHHCCCCCHHHHHHH	10.48	29514088
557	Ubiquitination	LLQCKAHLHANKPLS HHHHHHHHHCCCCCC	4.95	22817900
560	Ubiquitination	CKAHLHANKPLSVTD HHHHHHCCCCCCHHH	35.41	22817900
608	Phosphorylation	TSEVMHCSFSLKHCQ HHHHHEEEEEHHHHH	11.82	24719451
610	Phosphorylation	EVMHCSFSLKHCQDL HHHEEEEEHHHHHHH	21.88	24719451
665	Phosphorylation	LRSLRLWTDFCSLFS HHHHHHHHHHHHHHH	24.64	29083192
669	Phosphorylation	RLWTDFCSLFSSNSN HHHHHHHHHHHCCCC	32.23	29083192
672	Phosphorylation	TDFCSLFSSNSNLKF HHHHHHHHCCCCCEE	33.62	29083192
683	Ubiquitination	NLKFLEVKQSFLSDS CCEEEEEHHHHCCCC	30.74	-
732	Phosphorylation	LAFIGKKTLTHLTLA HHHHCCCCCCHHHHC	40.13	-
734	Phosphorylation	FIGKKTLTHLTLAGH HHCCCCCCHHHHCCC	21.77	-
737	Phosphorylation	KKTLTHLTLAGHIEW CCCCCHHHHCCCCHH	13.63	-
789 (in isoform 2)	Ubiquitination	-	55.81	21906983
810	Phosphorylation	DEGAMLLYKTMTRPK CHHHHHHHHHCCCCH	10.64	25884760
817	Ubiquitination	YKTMTRPKHFLQMLS HHHCCCCHHHHHHHC	43.64	2190698
817 (in isoform 1)	Ubiquitination	-	43.64	21906983
836	Acetylation	RLTEASCKDLAAVLV CCCHHHHHHHHHHHH	53.97	7666353
847	Acetylation	AVLVVSKKLTHLCLA HHHHHHHHHHHHHHH	51.62	7666363
849	Phosphorylation	LVVSKKLTHLCLAKN HHHHHHHHHHHHHCC	22.98	-
855	Acetylation	LTHLCLAKNPIGDTG HHHHHHHCCCCCCCH	50.76	7666373

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NALP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NALP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NALP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAF1_HUMAN	FAF1	physical	17046979
ZBT16_HUMAN	ZBTB16	physical	26121690

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 231090: Hydatidiform mole, recurrent, 1 (HYDM1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.