DHR13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHR13_HUMAN
• UniProt AC: Q6UX07
• Protein Name: Dehydrogenase/reductase SDR family member 13
• Gene Name: DHRS13
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Secreted .
• Protein Description: Putative oxidoreductase..
• Protein Sequence: MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLSKMTHRIQAKVEPEIQLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	MGNLRGRTAVVTGAN CCCCCCCEEEEECCC	26.99	-
42	Phosphorylation	RGRTAVVTGANSGIG CCCEEEEECCCCCHH	24.79	-
46	Phosphorylation	AVVTGANSGIGKMTA EEEECCCCCHHHHHH	31.11	-
50	"N6,N6-dimethyllysine"	GANSGIGKMTALELA CCCCCHHHHHHHHHH	31.02	-
50	Methylation	GANSGIGKMTALELA CCCCCHHHHHHHHHH	31.02	23644510
50	Ubiquitination	GANSGIGKMTALELA CCCCCHHHHHHHHHH	31.02	-
98	Phosphorylation	FMALDLASLASVRAF EEHHHHHHHHHHHHH	31.59	28302921
101	Phosphorylation	LDLASLASVRAFATA HHHHHHHHHHHHHHH	19.89	28302921
120	Ubiquitination	EPRLDILIHNAGISS CCCCEEEEECCCCCC	2.11	21890473
150	Phosphorylation	HIGPFLLTHLLLPCL CHHHHHHHHHHHHHH	16.78	-
151 (in isoform 2)	Ubiquitination	-	17.91	21890473
201	Ubiquitination	LRAYADTKLANVLFA HHHHCCHHHHHHHHH	46.26	21963094
201 (in isoform 1)	Ubiquitination	-	46.26	21890473
227	Ubiquitination	VTCYAAHPGPVNSEL CEEEECCCCCCCHHH	44.02	-
308	Ubiquitination	HRLWEASKRLAGLGP HHHHHHHHHHCCCCC	59.48	-
327	Phosphorylation	EPDEDPQSEDSEAPS CCCCCCCCCCCCCCC	49.08	23927012
330	Phosphorylation	EDPQSEDSEAPSSLS CCCCCCCCCCCCCCC	31.44	23927012
334	Phosphorylation	SEDSEAPSSLSTPHP CCCCCCCCCCCCCCC	51.46	28348404
335	Phosphorylation	EDSEAPSSLSTPHPE CCCCCCCCCCCCCCC	25.86	28348404
337	Phosphorylation	SEAPSSLSTPHPEEP CCCCCCCCCCCCCCC	41.67	28348404
338	Phosphorylation	EAPSSLSTPHPEEPT CCCCCCCCCCCCCCC	30.80	28348404
345	Phosphorylation	TPHPEEPTVSQPYPS CCCCCCCCCCCCCCC	35.75	22210691
347	Phosphorylation	HPEEPTVSQPYPSPQ CCCCCCCCCCCCCCC	28.10	22210691
350	Phosphorylation	EPTVSQPYPSPQSSP CCCCCCCCCCCCCCC	14.54	23909892
352	Phosphorylation	TVSQPYPSPQSSPDL CCCCCCCCCCCCCCH	29.72	25921289
355	Phosphorylation	QPYPSPQSSPDLSKM CCCCCCCCCCCHHHC	47.42	23909892
356	Phosphorylation	PYPSPQSSPDLSKMT CCCCCCCCCCHHHCH	19.72	25921289
377	Phosphorylation	VEPEIQLS------- CCCCCCCC-------	23.07	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHR13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHR13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHR13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KBP_HUMAN	KIAA1279	physical	26186194
KBP_HUMAN	KIAA1279	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.