TBL1Y_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBL1Y_HUMAN
• UniProt AC: Q9BQ87
• Protein Name: F-box-like/WD repeat-containing protein TBL1Y
• Gene Name: TBL1Y
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Nucleus.
• Protein Description: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity)..
• Protein Sequence: MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSITSDEVN ------CCCCHHHHH	34.28	-
4	Phosphorylation	----MSITSDEVNFL ----CCCCHHHHHHH	23.87	-
102	Acetylation	RQQAFGEKLTQQQAS HHHHHHHHHHHHHHH	58.16	-
130	Phosphorylation	TMTPAAISQQNPPKN HCCHHHHHCCCCCCC	22.46	-
180	Phosphorylation	TVLRGHESEVFICAW EEECCCCCCEEEEEC	33.13	27080861
234	Phosphorylation	EGGHDVPSNKDVTSL HCCCCCCCCCCCCCC	57.25	30624053
239	Phosphorylation	VPSNKDVTSLDWNSD CCCCCCCCCCCCCCC	33.43	30624053
240	Phosphorylation	PSNKDVTSLDWNSDG CCCCCCCCCCCCCCC	24.95	30624053
245	Phosphorylation	VTSLDWNSDGTLLAM CCCCCCCCCCCEEEE	32.91	30624053
248	Phosphorylation	LDWNSDGTLLAMGSY CCCCCCCCEEEEECC	24.48	30624053
311	Acetylation	DAHTGEAKQQFPFHS ECCCCCCHHCCCCCC	40.09	30592861
456	Phosphorylation	MKHQEPVYSVAFSPD HCCCCCEEEEEECCC	14.24	-
465	Ubiquitination	VAFSPDGKYLASGSF EEECCCCCEEECCCC	44.46	-
469	Phosphorylation	PDGKYLASGSFDKYV CCCCEEECCCCCCEE	32.16	20873877
471	Phosphorylation	GKYLASGSFDKYVHI CCEEECCCCCCEEEE	27.98	20873877
474	Methylation	LASGSFDKYVHIWNT EECCCCCCEEEEEEC	47.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBL1Y_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBL1Y_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBL1Y_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBL1X_HUMAN	TBL1X	physical	28514442
NCOR2_HUMAN	NCOR2	physical	28514442
TBL1R_HUMAN	TBL1XR1	physical	28514442
GPS2_HUMAN	GPS2	physical	28514442
NCOR1_HUMAN	NCOR1	physical	28514442
HDAC3_HUMAN	HDAC3	physical	28514442
CAN15_HUMAN	CAPN15	physical	28514442
INT6_HUMAN	INTS6	physical	28514442
M3K7_HUMAN	MAP3K7	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
DNJB1_HUMAN	DNAJB1	physical	28514442
WDR36_HUMAN	WDR36	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
DNJB4_HUMAN	DNAJB4	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
CHD8_HUMAN	CHD8	physical	28514442
FXL18_HUMAN	FBXL18	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.