U2AF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U2AF4_HUMAN
• UniProt AC: Q8WU68
• Protein Name: Splicing factor U2AF 26 kDa subunit
• Gene Name: U2AF1L4
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Nucleus . Nucleus speckle . Cytoplasm . Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling.
• Protein Description: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity)..
• Protein Sequence: MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQTIVLLNLYRNPQNTAQTADGSHCHVSDVEVQEHYDSFFEEVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISQNLQRQLYGRGPRRRSPPRFHTGHHPRERNHRCSPDHWHGRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEYLASIF ------CHHHHHHHH	17.72	-
4	Phosphorylation	----MAEYLASIFGT ----CHHHHHHHHCC	9.68	25106551
7	Phosphorylation	-MAEYLASIFGTEKD -CHHHHHHHHCCCCC	18.82	21955146
11	Phosphorylation	YLASIFGTEKDKVNC HHHHHHCCCCCCCCC	29.16	21955146
13	Acetylation	ASIFGTEKDKVNCSF HHHHCCCCCCCCCEE	63.79	54427329
13	Ubiquitination	ASIFGTEKDKVNCSF HHHHCCCCCCCCCEE	63.79	23000965
15	Sumoylation	IFGTEKDKVNCSFYF HHCCCCCCCCCEEEE	46.55	-
15	Ubiquitination	IFGTEKDKVNCSFYF HHCCCCCCCCCEEEE	46.55	23000965
19	Phosphorylation	EKDKVNCSFYFKIGV CCCCCCCEEEEEEEE	20.13	26055452
21	Phosphorylation	DKVNCSFYFKIGVCR CCCCCEEEEEEEECC	6.41	28152594
126	Phosphorylation	REEDGERAVAELSNR EHHCCHHHHHHHHHC	10.69	24719451
126 (in isoform 2)	Phosphorylation	-	10.69	24719451
144	Phosphorylation	GQAVHGELSPVTDFR CCCCCCCCCCCCCHH	9.20	24719451
144 (in isoform 2)	Phosphorylation	-	9.20	24719451
158	Phosphorylation	RESCCRQYEMGECTR HHHHCCHHCCCCCCC	6.63	24043423
164	Phosphorylation	QYEMGECTRGGFCNF HHCCCCCCCCCCCCE	28.22	24043423
165	Methylation	YEMGECTRGGFCNFM HCCCCCCCCCCCCEE	55.70	58860221
194	Phosphorylation	GRGPRRRSPPRFHTG CCCCCCCCCCCCCCC	37.13	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U2AF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U2AF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U2AF4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of U2AF4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.