MAP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAP6_HUMAN
• UniProt AC: Q96JE9
• Protein Name: Microtubule-associated protein 6
• Gene Name: MAP6
• Organism: Homo sapiens (Human).
• Sequence Length: 813
• Subcellular Localization: Cytoplasm, cytoskeleton . Golgi apparatus . Cell projection, axon . Cell projection, dendrite . Cytoplasmic vesicle, secretory vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Localizes predominantly in the proximal part of the axon (By similarit
• Protein Description: Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. [PubMed: 24357581 Regulates KIF5A-mediated axonal cargo transport (By similarity Regulates axonal growth during neuron polarization (By similarity]
• Protein Sequence: MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRVMIPTAPHTEYIESSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	S-palmitoylation	---MAWPCITRACCI ---CCCHHHHHHHHH	3.28	-
10	S-palmitoylation	WPCITRACCIARFWN CHHHHHHHHHHHHHH	1.23	-
11	S-palmitoylation	PCITRACCIARFWNQ HHHHHHHHHHHHHHH	2.38	-
31	O-linked_Glycosylation	IAVPLVFTKYSEATE CEEEEEEEECHHHCC	22.92	30379171
90	Phosphorylation	TGPAPGPTGEREPAA HCCCCCCCCCCCCCC	58.55	-
102	Phosphorylation	PAAGPGRSGPGPGLG CCCCCCCCCCCCCCC	56.08	21955146
110	Phosphorylation	GPGPGLGSGSTSGPA CCCCCCCCCCCCCCC	34.31	21955146
112	Phosphorylation	GPGLGSGSTSGPADS CCCCCCCCCCCCCHH	22.54	23684312
113	Phosphorylation	PGLGSGSTSGPADSV CCCCCCCCCCCCHHH	41.03	21955146
114	Phosphorylation	GLGSGSTSGPADSVM CCCCCCCCCCCHHHH	44.47	21955146
119	Phosphorylation	STSGPADSVMRQDYR CCCCCCHHHHHHHHH	21.66	21955146
143	Phosphorylation	SCRPRSEYQPSDAPF CCCCCCCCCCCCCCC	27.28	25884760
181	Phosphorylation	IPKPVQISAASQASA CCCCEEECCCCCCCC	10.74	27174698
184	Phosphorylation	PVQISAASQASAPIL CEEECCCCCCCCCCC	26.46	27174698
187	Phosphorylation	ISAASQASAPILGAP ECCCCCCCCCCCCCC	27.26	27174698
200	Phosphorylation	APKRRPQSQERWPVQ CCCCCCCCCCCCHHH	36.37	27174698
229	Ubiquitination	AGGLAAGKASGADER CCHHHHHHCCCCCHH	34.35	30230243
295	Phosphorylation	QIREEVASAVSSSYR HHHHHHHHHHHHHHH	34.09	29449344
298	Phosphorylation	EEVASAVSSSYRNEF HHHHHHHHHHHHHCC	17.18	29449344
299	Phosphorylation	EVASAVSSSYRNEFR HHHHHHHHHHHHCCC	25.45	29449344
300	Phosphorylation	VASAVSSSYRNEFRA HHHHHHHHHHHCCCC	22.17	29449344
301	Phosphorylation	ASAVSSSYRNEFRAW HHHHHHHHHHCCCCC	21.29	29449344
329	Acetylation	QYKPPDDKMVHETSY CCCCCCCCCCCCCCC	50.64	19826911
336	Phosphorylation	KMVHETSYSAQFKGE CCCCCCCCCEEECCC	18.55	25884760
346	Acetylation	QFKGEASKPTTADNK EECCCCCCCCCCCCC	54.13	19826595
362	Phosphorylation	IDRRRIRSLYSEPFK ECHHHHHHHHCCCCC	29.32	32142685
364	Phosphorylation	RRRIRSLYSEPFKEP HHHHHHHHCCCCCCC	16.54	25884760
369	Ubiquitination	SLYSEPFKEPPKVEK HHHCCCCCCCCCCCC	78.87	32142685
396	Acetylation	ASHKPTRKAKDKQAV CCCCCCCHHHHHHCC	63.37	69859
398	Acetylation	HKPTRKAKDKQAVSG CCCCCHHHHHHCCCH	69.37	69863
438	Acetylation	NNKLAEAKESLAQPV HHHHHHHHHHHCCCC	39.06	19818113
446	O-linked_Glycosylation	ESLAQPVSDSSKTQG HHHCCCCCCCCCCCC	38.16	30379171
457	O-linked_Glycosylation	KTQGPVATEPDKDQG CCCCCCCCCCCCCCC	48.57	30379171
487	Phosphorylation	EPLKKQGSVVPGPPK CCHHHCCCCCCCCCH	19.90	24719451
519	Phosphorylation	PEPLKNESPVISAPV CCCCCCCCCCEECCC	33.58	26657352
523	Phosphorylation	KNESPVISAPVKDQG CCCCCCEECCCCCCC	27.10	25332170
541	Phosphorylation	PVPPKNQSPMVPAKV CCCCCCCCCCCCCEE	25.10	24719451
553	Phosphorylation	AKVKDQGSVVPESLK CEECCCCCCCCHHHH	17.82	29759185
651	Phosphorylation	PEHPKDESAMATAPI CCCCCCCCCCCCCCC	33.21	28270605
655	Phosphorylation	KDESAMATAPIKNQG CCCCCCCCCCCCCCC	21.63	28270605
663	Phosphorylation	APIKNQGSMVSEPVK CCCCCCCCCCCCCCC	13.27	28270605
666	Phosphorylation	KNQGSMVSEPVKNQG CCCCCCCCCCCCCCC	27.78	28270605
791	Phosphorylation	PRDPQLPTVSPLPRV CCCCCCCCCCCCCCE	42.06	28348404
793	Phosphorylation	DPQLPTVSPLPRVMI CCCCCCCCCCCCEEC	24.17	24719451
811	Phosphorylation	PHTEYIESSP----- CCCHHHCCCC-----	38.05	27732954
812	Phosphorylation	HTEYIESSP------ CCHHHCCCC------	23.10	18510355

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAP6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MAP6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.