ZPLD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZPLD1_HUMAN
• UniProt AC: Q8TCW7
• Protein Name: Zona pellucida-like domain-containing protein 1
• Gene Name: ZPLD1
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Zona pellucida-like domain-containing protein 1: Cytoplasmic vesicle membrane ; Single-pass type I membrane protein .; Zona pellucida-like domain-containing protein 1, secreted form: Secreted, extracellular space, extracellular matrix .
• Protein Description: Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ..
• Protein Sequence: MEQIWLLLLLTIRVLPGSAQFNGYNCDANLHSRFPAERDISVYCGVQAITMKINFCTVLFSGYSETDLALNGRHGDSHCRGFINNNTFPAVVIFIINLSTLEGCGNNLVVSTIPGVSAYGNATSVQVGNISGYIDTPDPPTIISYLPGLLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFVSTLNLLLYNDSTYNQQLIIPSIGLPLKTKVFAAVQATNLDGRWNVLMDYCYTTPSGNPNDDIRYDLFLSCDKDPQTTVIENGRSQRGRFSFEVFRFVKHKNQKMSTVFLHCVTKLCRADDCPFLMPICSHRERRDAGRRTTWSPQSSSGSAVLSAGPIITRSDETPTNNSQLGSPSMPPFQLNAITSALISGMVILGVTSFSLLLCSLALLHRKGPTSLVLNGIRNPVFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	IWLLLLLTIRVLPGS HHHHHHHHHHHCCCC	13.50	24043423
18	Phosphorylation	TIRVLPGSAQFNGYN HHHHCCCCCHHCCCC	19.56	24043423
24	Phosphorylation	GSAQFNGYNCDANLH CCCHHCCCCCCCCHH	17.45	24043423
32	Phosphorylation	NCDANLHSRFPAERD CCCCCHHHCCCCCCC	38.49	24043423
121	N-linked_Glycosylation	PGVSAYGNATSVQVG CCCCCCCCCEEEEEC	27.63	UniProtKB CARBOHYD
164	N-linked_Glycosylation	YPLEYLVNNTQLASS CCHHHHCCCCEECCC	43.14	UniProtKB CARBOHYD
183	Phosphorylation	SVRENNGTFVSTLNL EEECCCCEEEEEEEE	24.00	24043423
186	Phosphorylation	ENNGTFVSTLNLLLY CCCCEEEEEEEEEEE	24.00	24043423
187	Phosphorylation	NNGTFVSTLNLLLYN CCCEEEEEEEEEEEC	17.86	24043423
193	Phosphorylation	STLNLLLYNDSTYNQ EEEEEEEECCCCCCE	19.52	24043423
196	Phosphorylation	NLLLYNDSTYNQQLI EEEEECCCCCCEEEE	29.20	24043423
197	Phosphorylation	LLLYNDSTYNQQLII EEEECCCCCCEEEEE	29.38	24043423
198	Phosphorylation	LLYNDSTYNQQLIIP EEECCCCCCEEEEEE	18.22	24043423
206	Phosphorylation	NQQLIIPSIGLPLKT CEEEEEECCCCCCCC	20.91	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZPLD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZPLD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZPLD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEAM8_HUMAN	CEACAM8	physical	28514442
GNPTA_HUMAN	GNPTAB	physical	28514442
CARL1_HUMAN	LRRC16A	physical	28514442
RTN4_HUMAN	RTN4	physical	28514442
TMX1_HUMAN	TMX1	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442
STEA2_HUMAN	STEAP2	physical	28514442
GNPTG_HUMAN	GNPTG	physical	28514442
F207A_HUMAN	FAM207A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.