STEA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STEA2_HUMAN
• UniProt AC: Q8NFT2
• Protein Name: Metalloreductase STEAP2
• Gene Name: STEAP2
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Endosome membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein .
• Protein Description: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity)..
• Protein Sequence: MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESISMMGSP -----CCCCCCCCCC	20.75	22199227
5	Phosphorylation	---MESISMMGSPKS ---CCCCCCCCCCCH	16.40	22199227
9	Phosphorylation	ESISMMGSPKSLSET CCCCCCCCCCHHHHC	15.97	28188228
12	Phosphorylation	SMMGSPKSLSETFLP CCCCCCCHHHHCCCC	40.28	25219547
14	Phosphorylation	MGSPKSLSETFLPNG CCCCCHHHHCCCCCC	41.50	25219547
16	Phosphorylation	SPKSLSETFLPNGIN CCCHHHHCCCCCCCC	27.39	25219547
26 (in isoform 2)	Ubiquitination	-	46.89	-
30 (in isoform 2)	Ubiquitination	-	43.93	-
32	Phosphorylation	IKDARKVTVGVIGSG CCCCCEEEEEEECCC	17.99	22210691
46	Phosphorylation	GDFAKSLTIRLIRCG CHHHHHHHHEEEECC	15.90	27174698
64 (in isoform 1)	Ubiquitination	-	58.05	21890473
64	Ubiquitination	VIGSRNPKFASEFFP EECCCCHHHHHHHCC	58.05	21890473
64	Ubiquitination	VIGSRNPKFASEFFP EECCCCHHHHHHHCC	58.05	21890473
64 (in isoform 2)	Ubiquitination	-	58.05	21890473
64	Ubiquitination	VIGSRNPKFASEFFP EECCCCHHHHHHHCC	58.05	21890473
99	Phosphorylation	AIHREHYTSLWDLRH EECHHHHCCHHHHHH	21.17	23898821
100	Phosphorylation	IHREHYTSLWDLRHL ECHHHHCCHHHHHHH	21.94	23898821
194	Phosphorylation	FIPIDLGSLSSAREI CCCCCCCCCCCHHHH	32.16	22617229
196	Phosphorylation	PIDLGSLSSAREIEN CCCCCCCCCHHHHHC	24.53	30108239
197	Phosphorylation	IDLGSLSSAREIENL CCCCCCCCHHHHHCC	36.32	30108239
467	Ubiquitination	RIKKGWEKSQFLEEG HHHCCHHHHHHHHCC	42.94	-
468	Phosphorylation	IKKGWEKSQFLEEGM HHCCHHHHHHHHCCC	18.04	29255136
478	Phosphorylation	LEEGMGGTIPHVSPE HHCCCCCCCCCCCHH	26.13	18578522
483	Phosphorylation	GGTIPHVSPERVTVM CCCCCCCCHHHCCCC	20.29	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STEA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STEA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STEA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of STEA2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.