dbPTM

XRP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XRP2_HUMAN
UniProt AC	O75695
Protein Name	Protein XRP2
Gene Name	RP2
Organism	Homo sapiens (Human).
Sequence Length	350
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Cell projection, cilium . Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Protein Description	Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins..
Protein Sequence	MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGCFFSKRR ------CCCCCCCCC	19.55	-
2	Myristoylation	------MGCFFSKRR ------CCCCCCCCC	19.55	10942419
3	S-palmitoylation	-----MGCFFSKRRK -----CCCCCCCCCC	2.76	10942419
13	Ubiquitination	SKRRKADKESRPENE CCCCCCCCCCCCCCH	63.55	-
15	Phosphorylation	RRKADKESRPENEEE CCCCCCCCCCCCHHH	59.90	25159151
25	Ubiquitination	ENEEERPKQYSWDQR CCHHHCCCCCCCHHH	69.00	-
27	Phosphorylation	EEERPKQYSWDQREK HHHCCCCCCCHHHHC	20.18	28796482
28	Phosphorylation	EERPKQYSWDQREKV HHCCCCCCCHHHHCC	22.98	28355574
34	Ubiquitination	YSWDQREKVDPKDYM CCCHHHHCCCHHHHC	54.87	-
38	Ubiquitination	QREKVDPKDYMFSGL HHHCCCHHHHCCCCC	57.96	21890473
40	Phosphorylation	EKVDPKDYMFSGLKD HCCCHHHHCCCCCCC	13.24	-
43	Phosphorylation	DPKDYMFSGLKDETV CHHHHCCCCCCCCCC	27.04	-
49	Phosphorylation	FSGLKDETVGRLPGT CCCCCCCCCCCCCCC	38.09	29759185
109	Ubiquitination	FRNCRDCKCTLACQQ EECCCCCCCEEEEEE	34.25	-
198	Phosphorylation	EDAVVQDYVPIPTTE CCCEECCCCCCCCHH	7.34	-
203	Phosphorylation	QDYVPIPTTEELKAV CCCCCCCCHHHHEEE	47.78	-
204	Phosphorylation	DYVPIPTTEELKAVR CCCCCCCHHHHEEEE	23.31	-
219	Phosphorylation	VSTEANRSIVPISRG EECCCCCCEEECCCC	27.95	23401153
224	Phosphorylation	NRSIVPISRGQRQKS CCCEEECCCCCCCCC	25.04	23401153
245	Phosphorylation	VVLFAGDYTIANARK EEEEECCCCHHHHHH	10.10	-
252	Ubiquitination	YTIANARKLIDEMVG CCHHHHHHHHHHHHC	47.59	-
260	Ubiquitination	LIDEMVGKGFFLVQT HHHHHHCCCEEEEEE	40.93	21890473
273	Ubiquitination	QTKEVSMKAEDAQRV EECEECCCHHHHHHH	40.91	21890473
284	Ubiquitination	AQRVFREKAPDFLPL HHHHHHHHCCCCHHH	62.05	-
341	Phosphorylation	SGDVDSFYNFADIQM CCCCHHHEEHHHHHC	17.21	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of XRP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2	G	Myristoylation	25255805
Myristoylated on Gly-2; which may be required for membrane targeting.
3	C	Palmitoylation	10942419
Palmitoylated on Cys-3; which may be required for plasma membrane targeting (Probable).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XRP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARL3_HUMAN	ARL3	physical	11847227
XPO7_HUMAN	XPO7	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
TNPO2_HUMAN	TNPO2	physical	26186194
NMT1_HUMAN	NMT1	physical	26186194
GLMN_HUMAN	GLMN	physical	26186194
XPO2_HUMAN	CSE1L	physical	26186194
TSC2_HUMAN	TSC2	physical	26186194
XPO4_HUMAN	XPO4	physical	26186194
ECM29_HUMAN	KIAA0368	physical	26186194
CSTF2_HUMAN	CSTF2	physical	26186194
DMXL2_HUMAN	DMXL2	physical	26186194
PDS5A_HUMAN	PDS5A	physical	26186194
OSTF1_HUMAN	OSTF1	physical	26186194
MTOR_HUMAN	MTOR	physical	26186194
TBL3_HUMAN	TBL3	physical	26186194
CND2_HUMAN	NCAPH	physical	26186194
SYMPK_HUMAN	SYMPK	physical	26186194
TARB1_HUMAN	TARBP1	physical	26186194
STAT3_HUMAN	STAT3	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
INT3_HUMAN	INTS3	physical	26186194
TRXR1_HUMAN	TXNRD1	physical	26186194
KNTC1_HUMAN	KNTC1	physical	26186194
UBP24_HUMAN	USP24	physical	26186194
KC1D_HUMAN	CSNK1D	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
COG7_HUMAN	COG7	physical	26186194
MARC2_HUMAN	MARC2	physical	26186194
CTL2_HUMAN	SLC44A2	physical	26186194
TKFC_HUMAN	DAK	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
MRRP3_HUMAN	KIAA0391	physical	26186194
CTU1_HUMAN	CTU1	physical	26186194
TRIPC_HUMAN	TRIP12	physical	26186194
QSOX1_HUMAN	QSOX1	physical	26186194
CTL2_HUMAN	SLC44A2	physical	28514442
MARC2_HUMAN	MARC2	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
MTOR_HUMAN	MTOR	physical	28514442
KC1D_HUMAN	CSNK1D	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
DMXL2_HUMAN	DMXL2	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
TKFC_HUMAN	DAK	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
QSOX1_HUMAN	QSOX1	physical	28514442
TRIPC_HUMAN	TRIP12	physical	28514442
SYMPK_HUMAN	SYMPK	physical	28514442
UBP24_HUMAN	USP24	physical	28514442
TSC2_HUMAN	TSC2	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
COG8_HUMAN	COG8	physical	28514442
TRXR1_HUMAN	TXNRD1	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
ECM29_HUMAN	KIAA0368	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442

Drug and Disease Associations

Kegg Disease
H00527	Retinitis pigmentosa (RP)
OMIM Disease
312600	Retinitis pigmentosa 2 (RP2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of XRP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND MASSSPECTROMETRY.	17081983 [Abstract]

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