RIMS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIMS4_HUMAN
• UniProt AC: Q9H426
• Protein Name: Regulating synaptic membrane exocytosis protein 4
• Gene Name: RIMS4
• Organism: Homo sapiens (Human).
• Sequence Length: 269
• Subcellular Localization: Cell junction, synapse.
• Protein Description: Regulates synaptic membrane exocytosis..
• Protein Sequence: MERSQSRLSLSASFEALAIYFPCMNSFDDEDAGDSRRLKGAIQRSTETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MERSQSRLSLS ----CCCCHHHHHHH	21.14	17525332
39	Ubiquitination	AGDSRRLKGAIQRST CCCCHHHHHHHHHHH	44.47	29967540
45	Phosphorylation	LKGAIQRSTETGLAV HHHHHHHHHCCCCEE	17.77	27732954
46	Phosphorylation	KGAIQRSTETGLAVE HHHHHHHHCCCCEEE	39.49	27732954
48	Phosphorylation	AIQRSTETGLAVEMP HHHHHHCCCCEEECC	37.27	27732954
146	Phosphorylation	GLTAKPGSKTLPAAY CCCCCCCCCCCCHHH	30.87	-
254	Phosphorylation	GPLLRQASQLSLEST HHHHHHHHHCCCCCC	24.26	17525332
255	Phosphorylation	PLLRQASQLSLESTV HHHHHHHHCCCCCCC	37.78	27251275
257	Phosphorylation	LRQASQLSLESTVGP HHHHHHCCCCCCCCC	23.58	17525332
258	Phosphorylation	RQASQLSLESTVGPC HHHHHCCCCCCCCCC	9.07	27251275
260	Phosphorylation	ASQLSLESTVGPCGE HHHCCCCCCCCCCCC	33.41	27251275
261	Phosphorylation	SQLSLESTVGPCGER HHCCCCCCCCCCCCC	21.80	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIMS4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIMS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIMS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-254 AND SER-257,AND MASS SPECTROMETRY.
PubMed: 17525332