RB39A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB39A_HUMAN
• UniProt AC: Q14964
• Protein Name: Ras-related protein Rab-39A
• Gene Name: RAB39A
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor; Cytoplasmic side. Lysosome . Recruited to phagosomes containing S.aureus or M.tuberculosis.
• Protein Description: Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K. [PubMed: 24349490 May be involved in multiple neurite formation (By similarity]
• Protein Sequence: METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMYVQPFRIVFLLVGHKCDLASQRQVTREEAEKLSADCGMKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFVPNTVHSSEEAVKPRKECFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Ubiquitination	LLEIEPGKRIKLQLW HHCCCCCCCEEEEEE	62.76	23000965
63	Acetylation	IEPGKRIKLQLWDTA CCCCCCEEEEEECCC	33.93	23954790
63	Succinylation	IEPGKRIKLQLWDTA CCCCCCEEEEEECCC	33.93	23954790
63	Ubiquitination	IEPGKRIKLQLWDTA CCCCCCEEEEEECCC	33.93	23000965
63	Malonylation	IEPGKRIKLQLWDTA CCCCCCEEEEEECCC	33.93	26320211
69	Phosphorylation	IKLQLWDTAGQERFR EEEEEECCCCHHHHH	22.55	28857561
114	Phosphorylation	WLEEAKMYVQPFRIV HHHHHHHHCCCCEEE	8.67	25884760
144	Ubiquitination	VTREEAEKLSADCGM CCHHHHHHHHHHHCC	55.58	-
180	Ubiquitination	RDIYELIKKGEICIQ HHHHHHHHCCCCEEE	68.31	-
195	Phosphorylation	DGWEGVKSGFVPNTV CCCCCHHHCCCCCCC	34.75	23312004
201	Phosphorylation	KSGFVPNTVHSSEEA HHCCCCCCCCCCHHH	17.33	23312004
204	Phosphorylation	FVPNTVHSSEEAVKP CCCCCCCCCHHHCCC	34.80	23312004
205	Phosphorylation	VPNTVHSSEEAVKPR CCCCCCCCHHHCCCC	25.28	23312004
210	Ubiquitination	HSSEEAVKPRKECFC CCCHHHCCCCCCCCC	46.26	32142685
215	Geranylgeranylation	AVKPRKECFC----- HCCCCCCCCC-----	4.78	-
217	Geranylgeranylation	KPRKECFC------- CCCCCCCC-------	9.13	-
217	Methylation	KPRKECFC------- CCCCCCCC-------	9.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB39A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB39A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB39A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.