PRTG_HUMAN - dbPTM
PRTG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRTG_HUMAN
UniProt AC Q2VWP7
Protein Name Protogenin
Gene Name PRTG {ECO:0000312|HGNC:HGNC:26373}
Organism Homo sapiens (Human).
Sequence Length 1150
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description May play a role in anteroposterior axis elongation..
Protein Sequence MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMPMIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQPGTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLSSVISTTPPNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
89PhosphorylationNKRIEVLSNGSLYIS
CCCEEECCCCCEEEE		44.3023532336
90N-linked_GlycosylationKRIEVLSNGSLYISE
CCEEECCCCCEEEEE		39.65UniProtKB CARBOHYD
94PhosphorylationVLSNGSLYISEVEGR
ECCCCCEEEEEEECC		12.2323532336
96PhosphorylationSNGSLYISEVEGRRG
CCCCEEEEEEECCCC		23.2529759185
174PhosphorylationTWEFNRTTLPMTMDR
EEEECCCCCCCCHHH		26.1525690035
178PhosphorylationNRTTLPMTMDRITAL
CCCCCCCCHHHEEEC		17.6121712546
196O-linked_GlycosylationVLQIYDVSQRDSGNY
EEEEEECCCCCCCCE		19.3229351928
216PhosphorylationTVAHRRKSMEASLTV
EEHHHHHHCCCCEEE		21.7529514088
220PhosphorylationRRKSMEASLTVIPAK
HHHHCCCCEEEEECC		15.9729514088
222PhosphorylationKSMEASLTVIPAKES
HHCCCCEEEEECCCC		17.5629514088
292PhosphorylationGNGNLMISDVRLQHA
CCCCEEEEEEEECCC		18.9822210691
302PhosphorylationRLQHAGVYVCRATTP
EECCCEEEEEEECCC		7.9124719451
308PhosphorylationVYVCRATTPGTRNFT
EEEEEECCCCCCCCE		20.8024719451
369PhosphorylationKNGRKIHSNGRIKMY
CCCCEECCCCCEEEE		44.4424719451
403PhosphorylationMAENSQGSILSRARL
HHHCCCCCEECEEEE		16.8424719451
406PhosphorylationNSQGSILSRARLTVV
CCCCCEECEEEEEEE		23.4024719451
456PhosphorylationVIAYSVHYMKAEGLN
EEEEEEEEEEECCCC		9.73-
488N-linked_GlycosylationDDLEPASNYTFYIVA
CCCCCCCCCEEEEEE		41.80UniProtKB CARBOHYD
592PhosphorylationSVYLVRITAATRVGL
CEEEEEEEECEEECC		10.3217081983
595PhosphorylationLVRITAATRVGLGES
EEEEEECEEECCCCC		24.3524505115
610PhosphorylationSVWTSHRTPKATSVK
CCCCCCCCCCCCCCC		24.5821712546
614PhosphorylationSHRTPKATSVKAPKS
CCCCCCCCCCCCCCC		39.9321712546
621PhosphorylationTSVKAPKSPELHLEP
CCCCCCCCCCCCEEE		23.6522210691
630N-linked_GlycosylationELHLEPLNCTTISVR
CCCEEECCCEEEEEE		31.63UniProtKB CARBOHYD
632PhosphorylationHLEPLNCTTISVRWQ
CEEECCCEEEEEEEE		26.5422210691
633PhosphorylationLEPLNCTTISVRWQQ
EEECCCEEEEEEEEC		17.2922210691
635PhosphorylationPLNCTTISVRWQQDV
ECCCEEEEEEEECCH		11.9722210691
729PhosphorylationPPPPHHLYAKANTSS
CCCCCCEEEECCCCC		11.16-
756PhosphorylationAAQIINYTIRCNPVG
HHHHHHEEEECCCCC		9.4724719451
896UbiquitinationNVYIVKISASNEVGE
CEEEEEEECCCCCCC		21.6722817900
899UbiquitinationIVKISASNEVGEGPF
EEEEECCCCCCCCCC		47.9221963094
904UbiquitinationASNEVGEGPFSNSVE
CCCCCCCCCCCCCEE		23.7121963094
974UbiquitinationLILIYRSKARKSSAS
HHHHHHHHHCCCCCC		43.1222817900
977UbiquitinationIYRSKARKSSASKTA
HHHHHHCCCCCCCCC		54.3321963094
982UbiquitinationARKSSASKTAQNGTQ
HCCCCCCCCCCCCCC		47.8221963094
988PhosphorylationSKTAQNGTQQLPRTS
CCCCCCCCCCCCCCC		22.2324173317
995PhosphorylationTQQLPRTSASLASGN
CCCCCCCCCCCCCCC		19.6924173317
997PhosphorylationQLPRTSASLASGNEV
CCCCCCCCCCCCCCC		25.0024173317
1000PhosphorylationRTSASLASGNEVGKN
CCCCCCCCCCCCCCC		47.6624173317
1017PhosphorylationGAVGNEESLMPMIMP
CCCCCHHHCCCEECC		24.6424173317
1026PhosphorylationMPMIMPNSFIDAKGG
CCEECCCCCCCCCCC		20.0824173317
1040PhosphorylationGTDLIINSYGPIIKN
CCEEEEECCCCEECC		22.5124173317
1041PhosphorylationTDLIINSYGPIIKNN
CEEEEECCCCEECCC		23.5624173317
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRTG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRTG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRTG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRTG_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRTG_HUMAN

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Related Literatures of Post-Translational Modification

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