RTN4R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTN4R_HUMAN
• UniProt AC: Q9BZR6
• Protein Name: Reticulon-4 receptor
• Gene Name: RTN4R
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Cell projection, axon . Perikaryon . Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.
• Protein Description: Receptor for RTN4, OMG and MAG. [PubMed: 12037567]
• Protein Sequence: MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	N-linked_Glycosylation	ASFRACRNLTILWLH HHHHHHHCCEEEEEC	41.23	12718853
82	N-linked_Glycosylation	ASFRACRNLTILWLH HHHHHHHCCEEEEEC	41.23	12718853
179	N-linked_Glycosylation	DTFRDLGNLTHLFLH CCHHHHHHCCEEECC	49.41	12718853
179	N-linked_Glycosylation	DTFRDLGNLTHLFLH CCHHHHHHCCEEECC	49.41	12718853
191	Phosphorylation	FLHGNRISSVPERAF ECCCCCCCCCCHHHH	23.26	23403867
239	Phosphorylation	YLFANNLSALPTEAL HHHHCCCCCCCHHHH	29.86	22210691
372	N-linked_Glycosylation	PGDSPPGNGSGPRHI CCCCCCCCCCCCCCC	47.43	-
372	N-linked_Glycosylation	PGDSPPGNGSGPRHI CCCCCCCCCCCCCCC	47.43	19349973
390	O-linked_Glycosylation	PFGTLPGSAEPPLTA CCCCCCCCCCCCCEE	27.76	OGP
447	GPI-anchor	GTGDSEGSGALPSLT CCCCCCCCCCCCCCE	19.48	-
458	Phosphorylation	PSLTCSLTPLGLALV CCCEECCCHHHHHHH	10.52	22210691
468	Phosphorylation	GLALVLWTVLGPC-- HHHHHHHHHHCCC--	11.16	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTN4R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTN4R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTN4R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OMGP_HUMAN	OMG	physical	12068310
ARHGP_HUMAN	ARHGEF25	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of the Nogo receptor ectodomain: a recognition moduleimplicated in myelin inhibition.";
He X.L., Bazan J.F., McDermott G., Park J.B., Wang K.,Tessier-Lavigne M., He Z., Garcia K.C.;
Neuron 38:177-185(2003).
Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 26-310, DISULFIDE BONDS, ANDGLYCOSYLATION AT ASN-82 AND ASN-179.
PubMed: 12718853