OMGP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OMGP_HUMAN
• UniProt AC: P23515
• Protein Name: Oligodendrocyte-myelin glycoprotein
• Gene Name: OMG
• Organism: Homo sapiens (Human).
• Sequence Length: 440
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system..
• Protein Sequence: MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	N-linked_Glycosylation	HVDCSGRNLSTLPSG CCCCCCCCHHCCCCC	41.70	UniProtKB CARBOHYD
61	N-linked_Glycosylation	QENIIHLNLSYNHFT HHCEEEEEECCCCHH	16.87	UniProtKB CARBOHYD
103	N-linked_Glycosylation	HLPRSLWNMSAANNN CCCHHHHCHHHCCCC	21.59	UniProtKB CARBOHYD
112	Ubiquitination	SAANNNIKLLDKSDT HHCCCCEEEECCCCC	45.16	30230243
132	Acetylation	LKYLDVSKNMLEKVV CEEEECCHHHHHHHH	46.34	19413330
152	N-linked_Glycosylation	LRSLEVLNLSSNKLW HHCCEEEECCCCCCE	42.95	UniProtKB CARBOHYD
154	O-linked_Glycosylation	SLEVLNLSSNKLWTV CCEEEECCCCCCEEE	30.69	28657654
167	Phosphorylation	TVPTNMPSKLHIVDL EECCCCCCCEEEEEC	36.76	29116813
176	N-linked_Glycosylation	LHIVDLSNNSLTQIL EEEEECCCCCCCCCC	49.78	UniProtKB CARBOHYD
189	N-linked_Glycosylation	ILPGTLINLTNLTHL CCCCCEEECCCCEEE	43.88	UniProtKB CARBOHYD
192	N-linked_Glycosylation	GTLINLTNLTHLYLH CCEEECCCCEEEEEE	46.22	UniProtKB CARBOHYD
234	N-linked_Glycosylation	WSCDHKQNITYLLKW CCCCHHHHHHHHHHH	33.11	UniProtKB CARBOHYD
236	Phosphorylation	CDHKQNITYLLKWMM CCHHHHHHHHHHHHH	18.70	24114839
237	Phosphorylation	DHKQNITYLLKWMME CHHHHHHHHHHHHHH	13.26	24114839
259	Phosphorylation	TPCSTQISSLKEHNM CCCHHHHHHHHHCCC	21.57	24719451
285	Phosphorylation	FTVSGMQTVDTINSL EEECCCCEEEECCEE	16.08	-
301	Phosphorylation	VVTQPKVTKIPKQYR EEECCCCCCCCCCCC	29.40	-
312	Phosphorylation	KQYRTKETTFGATLS CCCCCCCCCCCCEEC	29.05	-
313	Phosphorylation	QYRTKETTFGATLSK CCCCCCCCCCCEECC	22.59	-
317	Phosphorylation	KETTFGATLSKDTTF CCCCCCCEECCCCCC	31.76	-
364	N-linked_Glycosylation	LQDGMVTNTSLTSST ECCCCEEECCCCCCC	19.09	UniProtKB CARBOHYD
389	N-linked_Glycosylation	ITSGMPNNFSEMPQQ EECCCCCCHHCCCCC	35.63	UniProtKB CARBOHYD
417	GPI-anchor	NVKTPLPSVANAWKV CCCCCCCCHHHHHHC	41.36	-
425	N-linked_Glycosylation	VANAWKVNASFLLLL HHHHHHCCHHHHHHH	26.58	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OMGP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OMGP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OMGP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OMGP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.