SGCE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGCE_HUMAN
• UniProt AC: O43556
• Protein Name: Epsilon-sarcoglycan
• Gene Name: SGCE
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Subcellular Localization: Cell membrane, sarcolemma; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cell projection, dendrite. Golgi apparatus.
• Protein Description: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix..
• Protein Sequence: MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	MSPATTGTFLLTVYS CCCCCHHHHHHHHHH	14.71	29759185
36	Phosphorylation	TTGTFLLTVYSIFSK CHHHHHHHHHHHHHH	21.39	-
38	Phosphorylation	GTFLLTVYSIFSKVH HHHHHHHHHHHHHHC	7.27	-
39	Phosphorylation	TFLLTVYSIFSKVHS HHHHHHHHHHHHHCC	16.90	-
42	Phosphorylation	LTVYSIFSKVHSDRN HHHHHHHHHHCCCCC	31.90	24719451
46	Phosphorylation	SIFSKVHSDRNVYPS HHHHHHCCCCCCCCC	41.05	-
200	N-linked_Glycosylation	PERLNAINITSALDR HHHHCCCCCCHHHHC	29.13	19159218
249	Phosphorylation	PQNQLRCSQEMEPVI HHHCCCCCCCCCCEE	23.81	-
257	Phosphorylation	QEMEPVITCDKKFRT CCCCCEEECCHHHCE	18.19	-
278	Ubiquitination	CKISLVDKTKQVSTY EEEEEECCCCCCCCH	50.58	-
280	Ubiquitination	ISLVDKTKQVSTYQE EEEECCCCCCCCHHH	55.21	21906983
280	Ubiquitination	ISLVDKTKQVSTYQE EEEECCCCCCCCHHH	55.21	21906983
283	Phosphorylation	VDKTKQVSTYQEVIR ECCCCCCCCHHHHHC	20.92	26657352
284	Phosphorylation	DKTKQVSTYQEVIRG CCCCCCCCHHHHHCC	30.30	26657352
285	Phosphorylation	KTKQVSTYQEVIRGE CCCCCCCHHHHHCCC	8.65	26657352
302	Ubiquitination	LPDGGEYKPPSDSLK CCCCCCCCCCCHHCC	46.26	21906983
302	Ubiquitination	LPDGGEYKPPSDSLK CCCCCCCCCCCHHCC	46.26	21906983
337	Phosphorylation	VLFLILAYIMCCRRE HHHHHHHHHHHHHHH	5.92	-
353	Phosphorylation	VEKRNMQTPDIQLVH HHHCCCCCCCCCHHC	16.50	25159151
362	Phosphorylation	DIQLVHHSAIQKSTK CCCHHCHHHHHHHHH	16.52	28857561
369	Ubiquitination	SAIQKSTKELRDMSK HHHHHHHHHHHHHHH	62.94	-
406	Phosphorylation	PPLHTDNYDSTNMPL CCCCCCCCCCCCCCC	17.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGCE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGCE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGCE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SGCE_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00831: Primary dystonia
• OMIM Disease
• 159900: Dystonia 11 (DYT11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-200, AND MASSSPECTROMETRY.
PubMed: 19159218