S39A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S39A3_HUMAN
• UniProt AC: Q9BRY0
• Protein Name: Zinc transporter ZIP3
• Gene Name: SLC39A3
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Acts as a zinc-influx transporter..
• Protein Sequence: MVKLLVAKILCMVGVFFFMLLGSLLPVKIIETDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLQKVLSLGHISTDYPLAETILLLGFFMTVFLEQLILTFRKEKPSFIDLETFNAGSDVGSDSEYESPFMGGARGHALYVEPHGHGPSLSVQGLSRASPVRLLSLAFALSAHSVFEGLALGLQEEGEKVVSLFVGVAVHETLVAVALGISMARSAMPLRDAAKLAVTVSAMIPLGIGLGLGIESAQGVPGSVASVLLQGLAGGTFLFITFLEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFLKW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	IIETDFEKAHRSKKI EHHCCHHHHHHCHHH	49.87	33845483
98 (in isoform 2)	Phosphorylation	-	11.71	-
99 (in isoform 2)	Phosphorylation	-	3.28	-
112	Ubiquitination	ILTFRKEKPSFIDLE HHHHHHCCCCCEECE	49.34	-
114	Phosphorylation	TFRKEKPSFIDLETF HHHHCCCCCEECEEE	45.99	27422710
120	Phosphorylation	PSFIDLETFNAGSDV CCCEECEEECCCCCC	29.50	25693802
125	Phosphorylation	LETFNAGSDVGSDSE CEEECCCCCCCCCCC	27.06	26503892
129	Phosphorylation	NAGSDVGSDSEYESP CCCCCCCCCCCCCCC	37.50	26055452
131	Phosphorylation	GSDVGSDSEYESPFM CCCCCCCCCCCCCCC	43.72	26503892
133	Phosphorylation	DVGSDSEYESPFMGG CCCCCCCCCCCCCCC	26.17	25693802
135	Phosphorylation	GSDSEYESPFMGGAR CCCCCCCCCCCCCCC	23.65	20873877
147	Phosphorylation	GARGHALYVEPHGHG CCCCEEEEEECCCCC	11.98	25884760
156	Phosphorylation	EPHGHGPSLSVQGLS ECCCCCCCCCCCCCC	37.56	26356563
158	Phosphorylation	HGHGPSLSVQGLSRA CCCCCCCCCCCCCCC	19.41	26356563
163	Phosphorylation	SLSVQGLSRASPVRL CCCCCCCCCCCHHHH	32.40	23401153
164	Methylation	LSVQGLSRASPVRLL CCCCCCCCCCHHHHH	44.09	115917117
166	Phosphorylation	VQGLSRASPVRLLSL CCCCCCCCHHHHHHH	23.87	24719451
222	Phosphorylation	LGISMARSAMPLRDA HHHHHHHHCCCHHHH	21.27	18691976

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S39A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S39A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S39A3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S39A3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-129, ANDMASS SPECTROMETRY.
PubMed: 19369195

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-129, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-129, ANDMASS SPECTROMETRY.
PubMed: 18691976