OTUD1_HUMAN - dbPTM
OTUD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OTUD1_HUMAN
UniProt AC Q5VV17
Protein Name OTU domain-containing protein 1
Gene Name OTUD1
Organism Homo sapiens (Human).
Sequence Length 481
Subcellular Localization
Protein Description Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin..
Protein Sequence MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MQLYSSVCTHY
----CCCCCCCCCCC		5.0827642862
115PhosphorylationYTSTAQITVRALGAD
CCCCCEEEEEHHCCC		7.5823312004
163PhosphorylationPVPPRRGSSAWLLEE
CCCCCCCCHHHHHHH		18.3122777824
164PhosphorylationVPPRRGSSAWLLEEL
CCCCCCCHHHHHHHH		26.7022777824
196PhosphorylationPDRNFRLSEHRQALA
CCCCCCHHHHHHHHH		27.4028857561
213PhosphorylationKHRGPAATPGSPDPG
HHCCCCCCCCCCCCC		30.2329978859
216PhosphorylationGPAATPGSPDPGPGP
CCCCCCCCCCCCCCC		27.6025159151
272PhosphorylationGSIEAAPSSAAEPVI
CCCEECCCCCCCCEE		28.07-
289UbiquitinationRSDPRDEKLALYLAE
CCCCCHHHHHHHHHH		43.2629967540
293PhosphorylationRDEKLALYLAEVEKQ
CHHHHHHHHHHHHHH		9.7725159151
299UbiquitinationLYLAEVEKQDKYLRQ
HHHHHHHHHHHHHHH		69.8129967540
302UbiquitinationAEVEKQDKYLRQRNK
HHHHHHHHHHHHHCC		43.63-
327UbiquitinationCLYRAVSKTVYGDQS
HHEEEHHHHHHCCHH		35.1023000965
334PhosphorylationKTVYGDQSLHRELRE
HHHHCCHHHHHHHHH		30.7727251275
465PhosphorylationRDEELAKSMAISLSK
HHHHHHHHHHHHHHH		14.0830576142
469PhosphorylationLAKSMAISLSKMYIE
HHHHHHHHHHHHHHH		19.6324719451
471PhosphorylationKSMAISLSKMYIEQN
HHHHHHHHHHHHHHH		14.4830576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OTUD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OTUD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OTUD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FLNA_HUMANFLNAphysical
19615732
FLNB_HUMANFLNBphysical
19615732
FLNC_HUMANFLNCphysical
19615732
RD23A_HUMANRAD23Aphysical
19615732
RD23B_HUMANRAD23Bphysical
19615732
UBC_HUMANUBCphysical
23827681
RIPK1_HUMANRIPK1physical
23827681
P53_HUMANTP53physical
28216291
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OTUD1_HUMAN

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Related Literatures of Post-Translational Modification

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