CASK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASK_HUMAN
• UniProt AC: P07498
• Protein Name: Kappa-casein
• Gene Name: CSN3
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Secreted.
• Protein Description: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk..
• Protein Sequence: MKSFLLVVNALALTLPFLAVEVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLPNSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIITSTPETTTVAVTPPTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	AQIPQRQYLPNSHPP CCCCCHHCCCCCCCC	26.73	24043423
102	Phosphorylation	QRQYLPNSHPPTVVR CHHCCCCCCCCCCCC	35.12	24043423
106	Phosphorylation	LPNSHPPTVVRRPNL CCCCCCCCCCCCCCC	35.76	24043423
133	O-linked_Glycosylation	QDKIIIPTINTIATV CCCEEECCCCEEEEC	19.22	7460900
143	O-linked_Glycosylation	TIATVEPTPAPATEP EEEECCCCCCCCCCC	20.69	7460900
148	O-linked_Glycosylation	EPTPAPATEPTVDSV CCCCCCCCCCCCCCC	41.25	7460900
151	O-linked_Glycosylation	PAPATEPTVDSVVTP CCCCCCCCCCCCCCH	30.61	7460900
157	O-linked_Glycosylation	PTVDSVVTPEAFSES CCCCCCCCHHHHCHH	17.16	7460900
157	Phosphorylation	PTVDSVVTPEAFSES CCCCCCCCHHHHCHH	17.16	-
162	O-linked_Glycosylation	VVTPEAFSESIITST CCCHHHHCHHHCCCC	37.17	OGP
167	O-linked_Glycosylation	AFSESIITSTPETTT HHCHHHCCCCCCCEE	25.52	7460900
169	O-linked_Glycosylation	SESIITSTPETTTVA CHHHCCCCCCCEEEE	19.25	7460900
178	O-linked_Glycosylation	ETTTVAVTPPTA--- CCEEEEECCCCC---	17.51	7460900
181	O-linked_Glycosylation	TVAVTPPTA------ EEEECCCCC------	46.32	7460900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARE1_HUMAN	MAPRE1	physical	17350042
TBG1_HUMAN	TUBG1	physical	17350042
RBPMS_HUMAN	RBPMS	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Localisation and importance of the sugar part of human casein.";
Fiat A.-M., Jolles J., Aubert J.-P., Loucheux-Lefebvre M.H.,Jolles P.;
Eur. J. Biochem. 111:333-339(1980).
Cited for: PROTEIN SEQUENCE OF 118-182, AND GLYCOSYLATION AT THR-133; THR-143;THR-148; THR-151; THR-157; THR-167 AND THR-169.
PubMed: 7460900