dbPTM

CLIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLIP2_HUMAN
UniProt AC	Q9UDT6
Protein Name	CAP-Gly domain-containing linker protein 2
Gene Name	CLIP2
Organism	Homo sapiens (Human).
Sequence Length	1046
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Localizes preferentially to the ends of tyrosinated microtubules.
Protein Description	Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity)..
Protein Sequence	MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQKPSGLKPPGR ---CCCCCCCCCCCC	64.89	-
8	Acetylation	MQKPSGLKPPGRGGK CCCCCCCCCCCCCCC	53.33	7460757
17	Phosphorylation	PGRGGKHSSPMGRTS CCCCCCCCCCCCCCC	39.35	27732954
18	Phosphorylation	GRGGKHSSPMGRTST CCCCCCCCCCCCCCC	20.73	27732954
23	Phosphorylation	HSSPMGRTSTGSASS CCCCCCCCCCCCCCC	25.55	28450419
24	Phosphorylation	SSPMGRTSTGSASSS CCCCCCCCCCCCCCH	29.43	25159151
25	Phosphorylation	SPMGRTSTGSASSSA CCCCCCCCCCCCCHH	34.25	28450419
27	Phosphorylation	MGRTSTGSASSSAAV CCCCCCCCCCCHHHH	25.68	28450419
29	Phosphorylation	RTSTGSASSSAAVAA CCCCCCCCCHHHHHH	26.90	26434776
30	Phosphorylation	TSTGSASSSAAVAAS CCCCCCCCHHHHHHH	24.58	21712546
31	Phosphorylation	STGSASSSAAVAASS CCCCCCCHHHHHHHC	20.11	27251275
37	Phosphorylation	SSAAVAASSKEGSPL CHHHHHHHCCCCCCC	32.00	23312004
38	Phosphorylation	SAAVAASSKEGSPLH HHHHHHHCCCCCCCC	29.96	28985074
42	Phosphorylation	AASSKEGSPLHKQSS HHHCCCCCCCCCCCC	25.94	30266825
48	Phosphorylation	GSPLHKQSSGPSSSP CCCCCCCCCCCCCCH	41.91	23663014
49	Phosphorylation	SPLHKQSSGPSSSPA CCCCCCCCCCCCCHH	52.83	21712546
52	Phosphorylation	HKQSSGPSSSPAAAA CCCCCCCCCCHHHHH	47.15	23663014
53	Phosphorylation	KQSSGPSSSPAAAAA CCCCCCCCCHHHHHC	43.40	23401153
54	Phosphorylation	QSSGPSSSPAAAAAP CCCCCCCCHHHHHCC	23.93	25159151
143	Phosphorylation	QGIFTRPSKLTRQPT CCCCCCCHHCCCCCC	36.69	22210691
146	Phosphorylation	FTRPSKLTRQPTAEG CCCCHHCCCCCCCCC	30.87	23312004
150	Phosphorylation	SKLTRQPTAEGSGSD HHCCCCCCCCCCCCC	29.06	28060719
154	Phosphorylation	RQPTAEGSGSDAHSV CCCCCCCCCCCCCCH	26.99	28060719
156	Phosphorylation	PTAEGSGSDAHSVES CCCCCCCCCCCCHHH	33.06	28060719
160	Phosphorylation	GSGSDAHSVESLTAQ CCCCCCCCHHHHHCC	29.33	28060719
163	Phosphorylation	SDAHSVESLTAQNLS CCCCCHHHHHCCCCC	28.94	28060719
165	Phosphorylation	AHSVESLTAQNLSLH CCCHHHHHCCCCCCC	35.16	28060719
170	Phosphorylation	SLTAQNLSLHSGTAT HHHCCCCCCCCCCCC	31.42	28060719
173	Phosphorylation	AQNLSLHSGTATPPL CCCCCCCCCCCCCCC	43.03	28060719
175	Phosphorylation	NLSLHSGTATPPLTS CCCCCCCCCCCCCCC	30.30	28857561
177	Phosphorylation	SLHSGTATPPLTSRV CCCCCCCCCCCCCCE	25.85	25159151
181	Phosphorylation	GTATPPLTSRVIPLR CCCCCCCCCCEEECC	21.91	28060719
182	Phosphorylation	TATPPLTSRVIPLRE CCCCCCCCCEEECCH	32.03	28060719
190	Phosphorylation	RVIPLRESVLNSSVK CEEECCHHHHCCCCC	26.02	28857561
194	Phosphorylation	LRESVLNSSVKTGNE CCHHHHCCCCCCCCC	32.14	29255136
195	Phosphorylation	RESVLNSSVKTGNES CHHHHCCCCCCCCCC	26.93	23401153
198	Phosphorylation	VLNSSVKTGNESGSN HHCCCCCCCCCCCCC	42.98	29255136
202	Phosphorylation	SVKTGNESGSNLSDS CCCCCCCCCCCCCCC	52.07	29255136
204	Phosphorylation	KTGNESGSNLSDSGS CCCCCCCCCCCCCCC	43.83	29255136
207	Phosphorylation	NESGSNLSDSGSVKR CCCCCCCCCCCCCCC	33.70	23401153
209	Phosphorylation	SGSNLSDSGSVKRGE CCCCCCCCCCCCCCC	29.59	29255136
211	Phosphorylation	SNLSDSGSVKRGEKD CCCCCCCCCCCCCCC	28.54	29255136
231	Malonylation	RVLVGGTKTGVVRYV EEEECCCCCEEEEEE	46.70	26320211
267	Phosphorylation	NDGAVAGTRYFQCPP CCCCCCCCEEEECCC	16.68	24670416
284	Malonylation	GLFAPIHKVIRIGFP CCCCCCCEEHHCCCC	39.82	26320211
292	Phosphorylation	VIRIGFPSTSPAKAK EHHCCCCCCCHHHCH	38.98	22167270
293	Phosphorylation	IRIGFPSTSPAKAKK HHCCCCCCCHHHCHH	38.68	29255136
294	Phosphorylation	RIGFPSTSPAKAKKT HCCCCCCCHHHCHHH	27.48	19664994
309	Phosphorylation	KRMAMGVSALTHSPS HHHHCCHHHHHCCCC	16.31	24043423
312	Phosphorylation	AMGVSALTHSPSSSS HCCHHHHHCCCCCCC	21.74	26657352
314	Phosphorylation	GVSALTHSPSSSSIS CHHHHHCCCCCCCCC	22.65	26657352
316	Phosphorylation	SALTHSPSSSSISSV HHHHCCCCCCCCCCH	45.96	24043423
317	Phosphorylation	ALTHSPSSSSISSVS HHHCCCCCCCCCCHH	31.33	30108239
318	Phosphorylation	LTHSPSSSSISSVSS HHCCCCCCCCCCHHH	35.71	30108239
319	Phosphorylation	THSPSSSSISSVSSV HCCCCCCCCCCHHHH	28.56	30108239
321	Phosphorylation	SPSSSSISSVSSVAS CCCCCCCCCHHHHHH	27.00	30108239
322	Phosphorylation	PSSSSISSVSSVASS CCCCCCCCHHHHHHH	25.09	30108239
324	Phosphorylation	SSSISSVSSVASSVG CCCCCCHHHHHHHCC	22.50	24043423
325	Phosphorylation	SSISSVSSVASSVGG CCCCCHHHHHHHCCC	21.39	23312004
328	Phosphorylation	SSVSSVASSVGGRPS CCHHHHHHHCCCCCC	24.33	24043423
329	Phosphorylation	SVSSVASSVGGRPSR CHHHHHHHCCCCCCC	18.29	24043423
335	Phosphorylation	SSVGGRPSRSGLLTE HHCCCCCCCCCCCCH	37.40	24043423
337	Phosphorylation	VGGRPSRSGLLTETS CCCCCCCCCCCCHHC	37.82	20068231
341	Phosphorylation	PSRSGLLTETSSRYA CCCCCCCCHHCHHHH	42.11	20068231
343	Phosphorylation	RSGLLTETSSRYARK CCCCCCHHCHHHHHH	27.11	28857561
344	Phosphorylation	SGLLTETSSRYARKI CCCCCHHCHHHHHHH	13.44	28857561
345	Phosphorylation	GLLTETSSRYARKIS CCCCHHCHHHHHHHH	36.41	28857561
352	Phosphorylation	SRYARKISGTTALQE HHHHHHHHCHHHHHH	32.87	29255136
354	Phosphorylation	YARKISGTTALQEAL HHHHHHCHHHHHHHH	11.34	30266825
355	Phosphorylation	ARKISGTTALQEALK HHHHHCHHHHHHHHH	28.97	30266825
364	Ubiquitination	LQEALKEKQQHIEQL HHHHHHHHHHHHHHH	54.38	-
394	Acetylation	SHICEVEKEIALLKA HHHHHHHHHHHHHHH	60.64	25953088
394	Malonylation	SHICEVEKEIALLKA HHHHHHHHHHHHHHH	60.64	26320211
428	Malonylation	VESVRKEKVDLSNQL HHHHHHHHCCHHHHH	44.05	26320211
432	Phosphorylation	RKEKVDLSNQLEEER HHHHCCHHHHHHHHH	20.33	23312004
453	Phosphorylation	QFRVEEESITKGDLE HHHHHHHCCCCCCCH	38.55	21815630
476	Phosphorylation	RIGELEQSLLLEKAQ HHHHHHHHHHHHHHH	16.17	23684312
498	Phosphorylation	LADNRLTTVAEKSRV HHHCCCCHHHHHHHH	23.47	20068231
503	Phosphorylation	LTTVAEKSRVLQLEE CCHHHHHHHHHHHHH	21.08	20068231
551	Phosphorylation	RLRERLLSASKEHQR HHHHHHHHHCHHHHH	34.78	25106551
553	Phosphorylation	RERLLSASKEHQRES HHHHHHHCHHHHHHH	34.89	25627689
619	Phosphorylation	NWKSKLDSLASDHQK HHHHHHHHHHHHHHH	35.95	23312004
622	Phosphorylation	SKLDSLASDHQKSLE HHHHHHHHHHHHHHH	40.70	23312004
627	Phosphorylation	LASDHQKSLEDLKAT HHHHHHHHHHHHHHH	30.35	23312004
634	Phosphorylation	SLEDLKATLNSGPGA HHHHHHHHHHCCCCH	25.53	23312004
637	Phosphorylation	DLKATLNSGPGAQQK HHHHHHHCCCCHHHH	49.86	23312004
650	Acetylation	QKEIGELKAVMEGIK HHHHHHHHHHHHHCH	34.33	11688617
658	Sulfoxidation	AVMEGIKMEHQLELG HHHHHCHHHHHHHHC	5.41	30846556
782	Phosphorylation	QGKQEVESLREKLLV HCHHHHHHHHHHHHH	37.59	29449344
824	Phosphorylation	ETIRTKETVEGLQDK HHHHCHHHHHHHHHH	25.97	-
908	Phosphorylation	ELLRKERSLNELRVL HHHHHCCCHHHHHHH	36.32	24825855
923	Phosphorylation	LLEANRHSPGPERDL HHHHCCCCCCCCCHH	28.45	29255136
931	Phosphorylation	PGPERDLSREVHKAE CCCCCHHHHHHHHHH	30.59	24247654
972	Phosphorylation	SLSDQRRYSLIDRSS CCCHHHHHHHHCCCC	15.26	23403867
973	Phosphorylation	LSDQRRYSLIDRSSA CCHHHHHHHHCCCCH	19.62	25394399
978	Phosphorylation	RYSLIDRSSAPELLR HHHHHCCCCHHHHHH	27.40	23403867
979	Phosphorylation	YSLIDRSSAPELLRL HHHHCCCCHHHHHHH	49.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLIP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLAP1_HUMAN	CLASP1	physical	11290329
CLAP2_HUMAN	CLASP2	physical	11290329
CLAP1_MOUSE	Clasp1	physical	11290329

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLIP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-204; SER-207AND SER-211, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-923, AND MASSSPECTROMETRY.	17081983 [Abstract]