LRIQ3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRIQ3_HUMAN
• UniProt AC: A6PVS8
• Protein Name: Leucine-rich repeat and IQ domain-containing protein 3
• Gene Name: LRRIQ3
• Organism: Homo sapiens (Human).
• Sequence Length: 624
• Protein Sequence: MFHGTVTEELTSHEEWSHYNENIREGQKDFVFVKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKKGYRHVLVNSIWPLKALDHHVISDEEIIQNWHLPERFKACNHRLFFNFCPALRKGTTYEEEINNIKHITSKINAILAHNSPVLIVQRWIRGFLVRKNLSPVFFHKKKQQEKIIRGYEAKWIYITKGYEDKLLKDLFFKPETNIKGKLAYWKHNIYYPVDLKNSSEHRKHVSSILCELKPKDLGMKSKTSRHLIQKGQESEDEIVDEKLDTSFRISVFKLPIYTSGSLKNNAVLREKKQHFFPAYPQPIYTTHPKPIIKKDIRLERSMKEFFAPQRAGMKLRTFSDIDKYYTEQKKQEYHKEKVRVVAMAQVARERVRVAVNEHLNQKKYATQKLIEENKETIQNSLRQVWQNRFNYLEKARERKALFLKEKSQKASERLLVQNLNNERTLLTRGLLKIDRLEKNEAVLKEKSLIVKQKLKAEKYRKNLLKEMKKVRSQEIYKRHCEEKFVMDMIAFEKACERLQDAKTKVAIVKTNLDFKVPNGLIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
259	Phosphorylation	GYEAKWIYITKGYED CCEEEEEEEECCCHH	11.04	25690035
352	Phosphorylation	LDTSFRISVFKLPIY HCCCEEEEEEECCEE	19.76	24719451
359	Phosphorylation	SVFKLPIYTSGSLKN EEEECCEECCCCCCC	7.91	29978859
360	Phosphorylation	VFKLPIYTSGSLKNN EEECCEECCCCCCCC	27.60	29978859
361	Phosphorylation	FKLPIYTSGSLKNNA EECCEECCCCCCCCC	14.93	29978859
363	Phosphorylation	LPIYTSGSLKNNAVL CCEECCCCCCCCCCH	35.62	29978859
466	Phosphorylation	EHLNQKKYATQKLIE HHHHHHHHHHHHHHH	23.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRIQ3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRIQ3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRIQ3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
R3HCL_HUMAN	R3HCC1L	physical	26186194
GBB4_HUMAN	GNB4	physical	26186194
R3HCL_HUMAN	R3HCC1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.