dbPTM

RAPH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAPH1_HUMAN
UniProt AC	Q70E73
Protein Name	Ras-associated and pleckstrin homology domains-containing protein 1
Gene Name	RAPH1
Organism	Homo sapiens (Human).
Sequence Length	1250
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side . Cell projection, lamellipodium . Cell projection, filopodium . Cytoplasm, cytoskeleton . Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes wi
Protein Description	Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion..
Protein Sequence	MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQKLPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQLSDEE -------CCCCCHHH	34.43	21406692
5	Phosphorylation	---MEQLSDEEIDHG ---CCCCCHHHCCCC	42.54	22167270
5 (in isoform 6)	Phosphorylation	-	42.54	-
5 (in isoform 9)	Phosphorylation	-	42.54	-
17	Phosphorylation	DHGAEEDSDKEDQDL CCCCCCCCHHHHHHH	54.59	22167270
17 (in isoform 6)	Phosphorylation	-	54.59	-
17 (in isoform 9)	Phosphorylation	-	54.59	-
39	Phosphorylation	LGELDKLTQSLDSDK HHHHHHHHHHCCCCC	23.11	27732954
41	Phosphorylation	ELDKLTQSLDSDKPM HHHHHHHHCCCCCCC	28.98	25159151
44	Phosphorylation	KLTQSLDSDKPMEPV HHHHHCCCCCCCCCC	53.48	29514088
54	Phosphorylation	PMEPVKRSPLRQETN CCCCCCCCCCCCCCC	23.67	26055452
54 (in isoform 6)	Phosphorylation	-	23.67	-
54 (in isoform 9)	Phosphorylation	-	23.67	-
60	Phosphorylation	RSPLRQETNMANFSY CCCCCCCCCCCCEEE	23.19	22199227
118	Phosphorylation	QITETKATQKLPVSR EECCCCCCCCCCCCH	28.00	24719451
124	Phosphorylation	ATQKLPVSRHTLKHG CCCCCCCCHHHHCCC	19.19	29514088
127	Phosphorylation	KLPVSRHTLKHGTLK CCCCCHHHHCCCCCC	36.07	29514088
129	Methylation	PVSRHTLKHGTLKGL CCCHHHHCCCCCCCC	40.94	115976291
132	Phosphorylation	RHTLKHGTLKGLSSS HHHHCCCCCCCCCCC	25.64	-
134	Methylation	TLKHGTLKGLSSSSN HHCCCCCCCCCCCCC	58.61	24129315
140	Phosphorylation	LKGLSSSSNRIAKPS CCCCCCCCCCCCCCC	31.88	-
147	Phosphorylation	SNRIAKPSHASYSLD CCCCCCCCCCCCCHH	30.86	27251275
150	Phosphorylation	IAKPSHASYSLDDVT CCCCCCCCCCHHHHH	15.16	27251275
152	Phosphorylation	KPSHASYSLDDVTAQ CCCCCCCCHHHHHHH	23.87	23898821
190	Phosphorylation	VTNQHRRTASAGTVS CCCCCCCCCCCCCCC	25.56	30576142
192	Phosphorylation	NQHRRTASAGTVSDA CCCCCCCCCCCCCHH	26.98	30576142
195	Phosphorylation	RRTASAGTVSDAEVH CCCCCCCCCCHHEEE	19.29	30576142
197	Phosphorylation	TASAGTVSDAEVHSI CCCCCCCCHHEEEEC	30.82	28348404
203	Phosphorylation	VSDAEVHSISNSSHS CCHHEEEECCCCCCH	32.65	24275569
205	Phosphorylation	DAEVHSISNSSHSSI HHEEEECCCCCCHHH	33.40	28857561
207	Phosphorylation	EVHSISNSSHSSITS EEEECCCCCCHHHHH	23.72	28857561
208	Phosphorylation	VHSISNSSHSSITSA EEECCCCCCHHHHHH	31.47	24275569
210	Phosphorylation	SISNSSHSSITSAAS ECCCCCCHHHHHHHH	25.94	28348404
211	Phosphorylation	ISNSSHSSITSAASS CCCCCCHHHHHHHHC	25.18	23898821
213	Phosphorylation	NSSHSSITSAASSMD CCCCHHHHHHHHCCC	17.79	23898821
217	Phosphorylation	SSITSAASSMDSLDI HHHHHHHHCCCCCCC	26.38	23898821
218	Phosphorylation	SITSAASSMDSLDID HHHHHHHCCCCCCCC	23.14	24275569
236	Phosphorylation	RPQELDLTHQGQPIT CCHHCCCCCCCCCCC	16.30	28555341
243 (in isoform 3)	Phosphorylation	-	43.99	28348404
243 (in isoform 6)	Phosphorylation	-	43.99	28348404
243 (in isoform 7)	Phosphorylation	-	43.99	28348404
243 (in isoform 9)	Phosphorylation	-	43.99	28348404
248 (in isoform 3)	Phosphorylation	-	15.16	28348404
248 (in isoform 6)	Phosphorylation	-	15.16	28348404
248 (in isoform 7)	Phosphorylation	-	15.16	28348404
248 (in isoform 9)	Phosphorylation	-	15.16	28348404
250	Acetylation	TEEEQAAKLKAEKIR CHHHHHHHHHHHHHH	54.24	23954790
252 (in isoform 4)	Phosphorylation	-	54.51	21406692
252 (in isoform 8)	Phosphorylation	-	54.51	21406692
253 (in isoform 4)	Phosphorylation	-	33.48	21406692
253 (in isoform 8)	Phosphorylation	-	33.48	21406692
270	Acetylation	IKEAQVKKLVIRVHM HHHHHCCEEEEEEEC	49.48	7704377
279 (in isoform 6)	Phosphorylation	-	52.84	21406692
279 (in isoform 9)	Phosphorylation	-	52.84	21406692
280 (in isoform 6)	Phosphorylation	-	47.72	21406692
280 (in isoform 9)	Phosphorylation	-	47.72	21406692
281	Phosphorylation	RVHMSDDSSKTMMVD EEECCCCCCCCEEEC	38.43	22964224
282	Phosphorylation	VHMSDDSSKTMMVDE EECCCCCCCCEEECC	38.86	22964224
366	Phosphorylation	LFKNPQNYLLGKKET HHCCHHHHHCCCHHH	9.69	-
423	Phosphorylation	RYFLLRASGIYYVPK EEEEEECCEEEEECC	21.20	-
426	Phosphorylation	LLRASGIYYVPKGKA EEECCEEEEECCCCC	11.26	25839225
456	Phosphorylation	NVYYGQDYRNKYKAP EEECCCCCCCCCCCC	14.27	20417104
466	Phosphorylation	KYKAPTDYCLVLKHP CCCCCCCEEEEECCH	7.08	-
481	Phosphorylation	QIQKKSQYIKYLCCD HHHCHHHHHHHHCCC	13.38	-
483	Ubiquitination	QKKSQYIKYLCCDDV HCHHHHHHHHCCCCH	27.51	2189047
483 (in isoform 10)	Ubiquitination	-	27.51	21890473
483 (in isoform 2)	Ubiquitination	-	27.51	21890473
483 (in isoform 5)	Ubiquitination	-	27.51	21890473
508 (in isoform 4)	Ubiquitination	-	33.20	21890473
508 (in isoform 8)	Ubiquitination	-	33.20	21890473
510	Phosphorylation	AKYGKQLYMNYQEAL HHHHHHHHHHHHHHH	4.84	-
510 (in isoform 3)	Ubiquitination	-	4.84	21890473
510 (in isoform 7)	Ubiquitination	-	4.84	21890473
513	Phosphorylation	GKQLYMNYQEALKRT HHHHHHHHHHHHHCC	7.39	-
520	Phosphorylation	YQEALKRTESAYDWT HHHHHHCCCCCCCHH	32.48	21945579
522	Phosphorylation	EALKRTESAYDWTSL HHHHCCCCCCCHHHC	31.36	21945579
524	Phosphorylation	LKRTESAYDWTSLSS HHCCCCCCCHHHCCC	22.69	21945579
527	Phosphorylation	TESAYDWTSLSSSSI CCCCCCHHHCCCCCC	19.52	21945579
528	Phosphorylation	ESAYDWTSLSSSSIK CCCCCHHHCCCCCCC	23.23	21945579
530	Phosphorylation	AYDWTSLSSSSIKSG CCCHHHCCCCCCCCC	28.13	21945579
531	Phosphorylation	YDWTSLSSSSIKSGS CCHHHCCCCCCCCCC	33.14	21945579
532	Phosphorylation	DWTSLSSSSIKSGSS CHHHCCCCCCCCCCC	32.48	21945579
533	Phosphorylation	WTSLSSSSIKSGSSS HHHCCCCCCCCCCCC	35.66	21945579
535	Ubiquitination	SLSSSSIKSGSSSSS HCCCCCCCCCCCCCC	51.19	-
535 (in isoform 6)	Ubiquitination	-	51.19	21890473
535 (in isoform 9)	Ubiquitination	-	51.19	21890473
536	Phosphorylation	LSSSSIKSGSSSSSI CCCCCCCCCCCCCCC	42.09	21955146
538	Phosphorylation	SSSIKSGSSSSSIPE CCCCCCCCCCCCCCH	33.85	21955146
539	Phosphorylation	SSIKSGSSSSSIPES CCCCCCCCCCCCCHH	37.45	21955146
540	Phosphorylation	SIKSGSSSSSIPESQ CCCCCCCCCCCCHHH	29.78	21955146
541	Phosphorylation	IKSGSSSSSIPESQS CCCCCCCCCCCHHHC	33.95	21955146
542	Phosphorylation	KSGSSSSSIPESQSN CCCCCCCCCCHHHCC	44.07	21955146
546	Phosphorylation	SSSSIPESQSNHSNQ CCCCCCHHHCCCCCC	33.29	21955146
548	Phosphorylation	SSIPESQSNHSNQSD CCCCHHHCCCCCCCC	45.87	21955146
551	Phosphorylation	PESQSNHSNQSDSGV CHHHCCCCCCCCCCC	40.59	21955146
554	Phosphorylation	QSNHSNQSDSGVSDT HCCCCCCCCCCCCCC	37.68	21955146
556	Phosphorylation	NHSNQSDSGVSDTQP CCCCCCCCCCCCCCC	46.47	21955146
559	Phosphorylation	NQSDSGVSDTQPAGH CCCCCCCCCCCCCCC	38.17	21955146
561	Phosphorylation	SDSGVSDTQPAGHVR CCCCCCCCCCCCCCH	29.01	21955146
569	Phosphorylation	QPAGHVRSQSIVSSV CCCCCCHHHHHHHHH	27.47	28176443
571	Phosphorylation	AGHVRSQSIVSSVFS CCCCHHHHHHHHHHH	26.63	28176443
574	Phosphorylation	VRSQSIVSSVFSEAW CHHHHHHHHHHHHHH	21.08	22199227
575	Phosphorylation	RSQSIVSSVFSEAWK HHHHHHHHHHHHHHH	19.11	22199227
576 (in isoform 6)	Phosphorylation	-	4.82	-
576 (in isoform 9)	Phosphorylation	-	4.82	-
578	Phosphorylation	SIVSSVFSEAWKRGT HHHHHHHHHHHHHCC	25.01	22199227
582	Acetylation	SVFSEAWKRGTQLEE HHHHHHHHHCCCCHH	48.26	24469577
597	Phosphorylation	SSKARMESMNRPYTS HHHHHHHHCCCCCCC	16.41	21945579
602	Phosphorylation	MESMNRPYTSLVPPL HHHCCCCCCCCCCCC	13.01	21945579
603	Phosphorylation	ESMNRPYTSLVPPLS HHCCCCCCCCCCCCC	20.47	21945579
604	Phosphorylation	SMNRPYTSLVPPLSP HCCCCCCCCCCCCCC	22.86	21945579
610	Phosphorylation	TSLVPPLSPQPKIVT CCCCCCCCCCCCEEC	27.54	21945579
623 (in isoform 6)	Phosphorylation	-	39.77	-
623 (in isoform 9)	Phosphorylation	-	39.77	-
667	Phosphorylation	AAPMFVKYSTITRLQ CCCCEEEHHHHHHHC	13.02	30576142
762	Phosphorylation	ITQVAPPTPPPPPPI EEEECCCCCCCCCCC	47.57	25159151
784	O-linked_Glycosylation	APPKPLVTIPAPTST CCCCCCEEECCCCCC	29.00	31492838
784	O-linked_Glycosylation	APPKPLVTIPAPTST CCCCCCEEECCCCCC	29.00	20068230
793	Phosphorylation	PAPTSTKTVAPVVTQ CCCCCCCCCCCEECC	23.22	27251275
799	O-linked_Glycosylation	KTVAPVVTQAAPPTP CCCCCEECCCCCCCC	16.84	28657654
799	Phosphorylation	KTVAPVVTQAAPPTP CCCCCEECCCCCCCC	16.84	27251275
805	Phosphorylation	VTQAAPPTPTPPVPP ECCCCCCCCCCCCCC	38.44	30576142
807	Phosphorylation	QAAPPTPTPPVPPAK CCCCCCCCCCCCCCC	42.58	22199227
814	Acetylation	TPPVPPAKKQPAFPA CCCCCCCCCCCCCCH	58.68	26051181
822	Phosphorylation	KQPAFPASYIPPSPP CCCCCCHHHCCCCCC	24.67	25850435
823	Phosphorylation	QPAFPASYIPPSPPT CCCCCHHHCCCCCCC	21.39	22199227
827	Phosphorylation	PASYIPPSPPTPPVP CHHHCCCCCCCCCCC	37.85	25159151
830	Phosphorylation	YIPPSPPTPPVPVPP HCCCCCCCCCCCCCC	43.54	25159151
839	Phosphorylation	PVPVPPPTLPKQQSF CCCCCCCCCCCCCCC	62.56	22199227
845	Phosphorylation	PTLPKQQSFCAKPPP CCCCCCCCCCCCCCC	21.57	25159151
853	Phosphorylation	FCAKPPPSPLSPVPS CCCCCCCCCCCCCCH	44.22	25159151
856	Phosphorylation	KPPPSPLSPVPSVVK CCCCCCCCCCCHHHH	27.51	25159151
860	Phosphorylation	SPLSPVPSVVKQIAS CCCCCCCHHHHHHHH	39.51	21712546
867	Phosphorylation	SVVKQIASQFPPPPT HHHHHHHHCCCCCCC	33.70	22199227
874	Phosphorylation	SQFPPPPTPPAMESQ HCCCCCCCCCCCCCC	47.91	23927012
880	Phosphorylation	PTPPAMESQPLKPVP CCCCCCCCCCCCCCC	24.82	23927012
894	Phosphorylation	PANVAPQSPPAVKAK CCCCCCCCCCCCCCC	31.62	29255136
907	Phosphorylation	AKPKWQPSSIPVPSP CCCCCCCCCCCCCCC	26.29	20068231
908	Phosphorylation	KPKWQPSSIPVPSPD CCCCCCCCCCCCCCC	37.28	18669648
913	Phosphorylation	PSSIPVPSPDFPPPP CCCCCCCCCCCCCCC	37.02	20068231
923	Phosphorylation	FPPPPPESSLVFPPP CCCCCCHHHCCCCCC	34.44	20068231
924	Phosphorylation	PPPPPESSLVFPPPP CCCCCHHHCCCCCCC	27.22	20068231
933	Phosphorylation	VFPPPPPSPVPAPPP CCCCCCCCCCCCCCC	44.28	20068231
945	Phosphorylation	PPPPPPPTASPTPDK CCCCCCCCCCCCCCC	45.61	20068231
947	Phosphorylation	PPPPPTASPTPDKSG CCCCCCCCCCCCCCC	31.61	20068231
949	Phosphorylation	PPPTASPTPDKSGSP CCCCCCCCCCCCCCC	41.44	20068231
953	Phosphorylation	ASPTPDKSGSPGKKT CCCCCCCCCCCCCCC	52.46	24706070
955	Phosphorylation	PTPDKSGSPGKKTSK CCCCCCCCCCCCCCC	37.25	24706070
959	Acetylation	KSGSPGKKTSKTSSP CCCCCCCCCCCCCCC	65.04	19413330
960	Phosphorylation	SGSPGKKTSKTSSPG CCCCCCCCCCCCCCC	38.65	29496963
961	Phosphorylation	GSPGKKTSKTSSPGG CCCCCCCCCCCCCCC	42.70	29496963
963	Phosphorylation	PGKKTSKTSSPGGKK CCCCCCCCCCCCCCC	33.92	23403867
964	Phosphorylation	GKKTSKTSSPGGKKP CCCCCCCCCCCCCCC	37.97	23403867
965	Phosphorylation	KKTSKTSSPGGKKPP CCCCCCCCCCCCCCC	32.56	23927012
974	Phosphorylation	GGKKPPPTPQRNSSI CCCCCCCCCCCCCCC	37.52	23927012
979	Phosphorylation	PPTPQRNSSIKSSSG CCCCCCCCCCCCCCC	35.31	28348404
980	Phosphorylation	PTPQRNSSIKSSSGA CCCCCCCCCCCCCCC	37.27	22617229
983	Phosphorylation	QRNSSIKSSSGAEHP CCCCCCCCCCCCCCC	28.24	30576142
984	Phosphorylation	RNSSIKSSSGAEHPE CCCCCCCCCCCCCCC	27.99	22617229
985	Phosphorylation	NSSIKSSSGAEHPEP CCCCCCCCCCCCCCC	49.46	30576142
996	Phosphorylation	HPEPKRPSVDSLVSK CCCCCCCCHHHHHHC	42.46	25159151
999	Phosphorylation	PKRPSVDSLVSKFTP CCCCCHHHHHHCCCC	28.63	22199227
1002	Phosphorylation	PSVDSLVSKFTPPAE CCHHHHHHCCCCCHH	27.61	22199227
1005	Phosphorylation	DSLVSKFTPPAESGS HHHHHCCCCCHHCCC	31.90	22167270
1010	Phosphorylation	KFTPPAESGSPSKET CCCCCHHCCCCCCCC	46.83	30266825
1012	Phosphorylation	TPPAESGSPSKETLP CCCHHCCCCCCCCCC	34.97	30266825
1014	Phosphorylation	PAESGSPSKETLPPP CHHCCCCCCCCCCCC	44.83	30266825
1017	Phosphorylation	SGSPSKETLPPPAAP CCCCCCCCCCCCCCC	48.58	22167270
1033	Phosphorylation	KPGKLNLSGVNLPGV CCCCCCCCCCCCCHH	39.35	22199227
1047	Phosphorylation	VLQQGCVSAKAPVLS HHHCCCCCCCCCEEC	28.29	20068231
1054	Phosphorylation	SAKAPVLSGRGKDSV CCCCCEECCCCCCCC	27.03	24719451
1060	Phosphorylation	LSGRGKDSVVEFPSP ECCCCCCCCEECCCC	31.39	20068231
1066	Phosphorylation	DSVVEFPSPPSDSDF CCCEECCCCCCCCCC	55.55	20068231
1069	Phosphorylation	VEFPSPPSDSDFPPP EECCCCCCCCCCCCC	53.80	20068231
1071	Phosphorylation	FPSPPSDSDFPPPPP CCCCCCCCCCCCCCC	45.55	20068231
1080	Phosphorylation	FPPPPPETELPLPPI CCCCCCCCCCCCCCC	48.90	20068231
1094	Phosphorylation	IEIPAVFSGNTSPKV CCCCEEECCCCCCCE	25.24	28348404
1097	Phosphorylation	PAVFSGNTSPKVAVV CEEECCCCCCCEEEE	50.35	20068231
1098	Phosphorylation	AVFSGNTSPKVAVVN EEECCCCCCCEEEEC	27.07	25159151
1115	Phosphorylation	PQQWSKMSVKKAPPP CCHHCCCCCCCCCCC	34.22	24719451
1130	Phosphorylation	TRPKRNDSTRLTQAE CCCCCCCCCCCCHHH	20.98	29507054
1131	Phosphorylation	RPKRNDSTRLTQAEI CCCCCCCCCCCHHHH	32.34	30576142
1134	Phosphorylation	RNDSTRLTQAEISEQ CCCCCCCCHHHHCCC	23.57	23403867
1139	Phosphorylation	RLTQAEISEQPTMAT CCCHHHHCCCCCEEE	22.99	27987026
1143	Phosphorylation	AEISEQPTMATVVPQ HHHCCCCCEEEECCC	21.09	27987026
1146	Phosphorylation	SEQPTMATVVPQVPT CCCCCEEEECCCCCC	15.94	27987026
1153	Phosphorylation	TVVPQVPTSPKSSLS EECCCCCCCCCHHCC	59.82	29255136
1154	Phosphorylation	VVPQVPTSPKSSLSV ECCCCCCCCCHHCCC	25.02	29255136
1157	Phosphorylation	QVPTSPKSSLSVQPG CCCCCCCHHCCCCCC	39.64	27251275
1158	Phosphorylation	VPTSPKSSLSVQPGF CCCCCCHHCCCCCCH	30.69	27251275
1160	Phosphorylation	TSPKSSLSVQPGFLA CCCCHHCCCCCCHHH	22.21	27251275
1172	Phosphorylation	FLADLNRTLQRKSIT HHHHHHHHHHHHCHH	26.60	25159151
1177	Phosphorylation	NRTLQRKSITRHGSL HHHHHHHCHHCCCCH	31.23	22210691
1179	Phosphorylation	TLQRKSITRHGSLSS HHHHHCHHCCCCHHH	24.57	23090842
1183	Phosphorylation	KSITRHGSLSSRMSR HCHHCCCCHHHHHCC	20.96	25849741
1185	Phosphorylation	ITRHGSLSSRMSRAE HHCCCCHHHHHCCCC	20.00	23090842
1186	Phosphorylation	TRHGSLSSRMSRAEP HCCCCHHHHHCCCCC	36.98	23090842
1189	Phosphorylation	GSLSSRMSRAEPTAT CCHHHHHCCCCCCCC	27.51	22210691
1194	Phosphorylation	RMSRAEPTATMDDMA HHCCCCCCCCCCCCC	26.68	25954137
1196	Phosphorylation	SRAEPTATMDDMALP CCCCCCCCCCCCCCC	24.50	25954137
1206	Phosphorylation	DMALPPPPPELLSDQ CCCCCCCCHHHCCCH	40.55	15302935
1211	Phosphorylation	PPPPELLSDQQKAGY CCCHHHCCCHHHCCC	46.10	25954137
1221	Phosphorylation	QKAGYGGSHISGYAT HHCCCCCCCCCCCCC	17.18	25954137
1224	Phosphorylation	GYGGSHISGYATLRR CCCCCCCCCCCCCCC	21.96	28152594
1226	Phosphorylation	GGSHISGYATLRRGP CCCCCCCCCCCCCCC	6.93	21082442
1228	Phosphorylation	SHISGYATLRRGPPP CCCCCCCCCCCCCCC	16.59	28152594
1244	Phosphorylation	PPKRDQNTKLSRDW- CCCCCCCCCCCCCC-	27.94	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
426	Y	Phosphorylation	Kinase	ABL1	P00519	Uniprot
426	Y	Phosphorylation	Kinase	ABL1	P00520	GPS
456	Y	Phosphorylation	Kinase	ABL1	P00519	Uniprot
456	Y	Phosphorylation	Kinase	ABL1	P00520	GPS
513	Y	Phosphorylation	Kinase	ABL1	P00520	GPS
1226	Y	Phosphorylation	Kinase	ABL1	P00519	Uniprot
1226	Y	Phosphorylation	Kinase	ABL1	P00520	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAPH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAPH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENAH_HUMAN	ENAH	physical	15469845
VASP_HUMAN	VASP	physical	15469845
SIAH1_HUMAN	SIAH1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAPH1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-5; SER-17; SER-856; SER-894 AND SER-1154, ANDMASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-5; SER-17; SER-856; SER-894 AND SER-1154, ANDMASS SPECTROMETRY.	19413330 [Abstract]
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