| UniProt ID | MSH5_HUMAN | |
|---|---|---|
| UniProt AC | O43196 | |
| Protein Name | MutS protein homolog 5 | |
| Gene Name | MSH5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 834 | |
| Subcellular Localization | ||
| Protein Description | Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).. | |
| Protein Sequence | MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASLGANPRR -----CCCCCCCCCC | 26.49 | 24719451 | |
| 84 | Phosphorylation | PDAPDHESLKLLQRV CCCCCHHHHHHHHHH | 27.64 | 24719451 | |
| 105 (in isoform 1) | Ubiquitination | - | 59.03 | 21906983 | |
| 105 (in isoform 2) | Ubiquitination | - | 59.03 | 21906983 | |
| 105 (in isoform 4) | Ubiquitination | - | 59.03 | 21906983 | |
| 105 (in isoform 3) | Ubiquitination | - | 59.03 | 21906983 | |
| 105 | Ubiquitination | QSVVTSAKQDENMTR HHHHCCCCCCHHHHH | 59.03 | 21906983 | |
| 116 (in isoform 3) | Ubiquitination | - | 42.92 | - | |
| 135 | Phosphorylation | PEIIFLPSVDFGLEI CCEEEECCCCCCCHH | 36.14 | 23898821 | |
| 143 | Phosphorylation | VDFGLEISKQRLLSG CCCCCHHCCHHHHCC | 17.23 | 23898821 | |
| 205 (in isoform 3) | Ubiquitination | - | 20.66 | - | |
| 230 (in isoform 3) | Ubiquitination | - | 2.38 | - | |
| 235 | Phosphorylation | SVLQIFKSESHPSVY HHHHHHHCCCCHHHH | 33.32 | - | |
| 237 | Phosphorylation | LQIFKSESHPSVYKV HHHHHCCCCHHHHHH | 48.03 | - | |
| 240 | Phosphorylation | FKSESHPSVYKVASG HHCCCCHHHHHHHHC | 32.43 | - | |
| 242 | Phosphorylation | SESHPSVYKVASGLK CCCCHHHHHHHHCHH | 12.23 | - | |
| 266 (in isoform 3) | Ubiquitination | - | 13.99 | - | |
| 406 (in isoform 2) | Ubiquitination | - | 48.08 | 21906983 | |
| 406 (in isoform 1) | Ubiquitination | - | 48.08 | 21906983 | |
| 406 | Ubiquitination | IDPEIDEKKRRLMGL CCHHHCHHHHHHCCH | 48.08 | 2190698 | |
| 415 | Phosphorylation | RRLMGLPSFLTEVAR HHHCCHHHHHHHHHH | 37.62 | - | |
| 423 (in isoform 4) | Ubiquitination | - | 57.84 | 21906983 | |
| 423 (in isoform 3) | Ubiquitination | - | 57.84 | 21906983 | |
| 424 (in isoform 3) | Ubiquitination | - | 56.62 | - | |
| 440 (in isoform 3) | Ubiquitination | - | 1.21 | - | |
| 448 | Phosphorylation | PLIGFLLSIPRLPSM CCHHHHHCCCCCCCC | 32.47 | 24719451 | |
| 501 (in isoform 3) | Ubiquitination | - | 45.79 | - | |
| 537 | Phosphorylation | DVLLALASAARDYGY HHHHHHHHHHHHHCC | 24.26 | - | |
| 549 | Phosphorylation | YGYSRPRYSPQVLGV HCCCCCCCCCCEEEE | 27.64 | - | |
| 584 | Ubiquitination | STECGGDKGRVKVIT CCCCCCCCCCEEEEE | 52.47 | - | |
| 588 | Ubiquitination | GGDKGRVKVITGPNS CCCCCCEEEEECCCC | 26.93 | - | |
| 601 (in isoform 3) | Ubiquitination | - | 18.22 | - | |
| 605 (in isoform 3) | Ubiquitination | - | 6.87 | - | |
| 615 (in isoform 3) | Ubiquitination | - | 19.06 | - | |
| 742 | Phosphorylation | GNDLVFFYQVCEGVA CCEEEEEEEHHHHHH | 6.64 | - | |
| 789 (in isoform 3) | Ubiquitination | - | 58.42 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MSH5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MSH5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MSH5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MSH4_HUMAN | MSH4 | physical | 12591739 | |
| MSH4_HUMAN | MSH4 | physical | 9787078 | |
| MSH4_HUMAN | MSH4 | physical | 10029069 | |
| GPS2_HUMAN | GPS2 | physical | 16122992 | |
| ABL1_HUMAN | ABL1 | physical | 16397227 | |
| ABL1_HUMAN | ABL1 | physical | 19442657 | |
| FANCA_HUMAN | FANCA | physical | 28215707 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
