MSH4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSH4_HUMAN
• UniProt AC: O15457
• Protein Name: MutS protein homolog 4
• Gene Name: MSH4
• Organism: Homo sapiens (Human).
• Sequence Length: 936
• Protein Description: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis..
• Protein Sequence: MLRPEISSTSPSAPAVSPSSGETRSPQGPRYNFGLQETPQSRPSVQVVSASTCPGTSGAAGDRSSSSSSLPCPAPNSRPAQGSYFGNKRAYAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLEDKRFGIILEKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKTEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLRPEISSTSPSAP -CCCCCCCCCCCCCC	26.38	22210691
19	Phosphorylation	SAPAVSPSSGETRSP CCCCCCCCCCCCCCC	43.39	30576142
23	Phosphorylation	VSPSSGETRSPQGPR CCCCCCCCCCCCCCC	39.72	22210691
25	Phosphorylation	PSSGETRSPQGPRYN CCCCCCCCCCCCCCC	29.06	22210691
98	Phosphorylation	YAENTVASNFTFGAS CEECCEECCCEECCC	28.30	22210691
107	Phosphorylation	FTFGASSSSARDTNY CEECCCCCCCCCCCC	26.06	22210691
108	Phosphorylation	TFGASSSSARDTNYP EECCCCCCCCCCCCC	29.30	22210691
132	Phosphorylation	GNPQRSGYKSWTPQV CCCCCCCCCCCCCCC	11.77	22817900
175	Phosphorylation	RGEIGMASIDLKNPQ CCCCEEEEEECCCCE	14.03	24961811
226	Phosphorylation	GNSTKLFTLITENFK CCCHHEEEEECCCCC	27.90	27461979
229	Phosphorylation	TKLFTLITENFKNVN HHEEEEECCCCCCCC	28.17	27461979
285	Phosphorylation	AVAALLKYVEFIQNS HHHHHHHHHHHHHHC	12.75	26657352
292	Phosphorylation	YVEFIQNSVYAPKSL HHHHHHHCCCCCCEE	10.50	26546556
294	Phosphorylation	EFIQNSVYAPKSLKI HHHHHCCCCCCEEEE	19.60	26657352
334	Phosphorylation	QDYRNNHTLFGVLNY CCCCCCCEEEEEEEE	26.38	29978859
341	Phosphorylation	TLFGVLNYTKTPGGS EEEEEEEECCCCCCC	12.88	29978859
342	Phosphorylation	LFGVLNYTKTPGGSR EEEEEEECCCCCCCC	27.63	29978859
344	Phosphorylation	GVLNYTKTPGGSRRL EEEEECCCCCCCCCH	21.26	24719451
348	Phosphorylation	YTKTPGGSRRLRSNI ECCCCCCCCCHHHCC	21.83	23532336
353	Phosphorylation	GGSRRLRSNILEPLV CCCCCHHHCCCHHCC	32.58	29888752
364	Phosphorylation	EPLVDIETINMRLDC HHCCCHHHHHHHHHH	20.27	24719451
410	Phosphorylation	VQIPKQDTVNAAESK HCCCCCCCCCHHHHH	17.11	25072903
416	Phosphorylation	DTVNAAESKITNLIY CCCCHHHHHHHHHHH	25.32	25072903
456	Acetylation	YYGSLEDKRFGIILE HHCCCCCCCEEEHHH	40.01	26822725
467	Phosphorylation	IILEKIKTVINDDAR EHHHHHHHHHCCHHH	30.05	-
475	Phosphorylation	VINDDARYMKGCLNM HHCCHHHHHHHHHHC	12.61	-
492	Phosphorylation	QKCYAVRSNINEFLD HHHHHHHCCHHHHHH	35.15	-
524	Phosphorylation	SQLGEKYSLPLRTSF HHCCHHCCCCCCCCC	34.28	24719451
614	Phosphorylation	IHCLYKLSDTVSMLD HHHHHHHHHHHHHHH	27.38	22210691
616	Phosphorylation	CLYKLSDTVSMLDML HHHHHHHHHHHHHHH	15.88	22210691
633	Phosphorylation	FAHACTLSDYVRPEF HHHHCCHHHHCCCHH	14.56	22210691
704	Phosphorylation	QIMAQIGSYVPAEYS HHHHHHCCCCCCCHH	25.28	-
712	Phosphorylation	YVPAEYSSFRIAKQI CCCCCHHHHHHHHHH	20.04	-
783	Phosphorylation	AVCEYLLSLKAFTLF HHHHHHHHHHHHHHH	25.81	24719451
830	O-linked_Glycosylation	NKEAILYTYKLSKGL CCEEEEEEEECCCCC	15.67	30379171
865	Phosphorylation	VLDAKEITTQITRQI EECHHHHHHHHHHHH	17.46	18669648
878	Phosphorylation	QILQNQRSTPEMERQ HHHHCCCCCHHHHHH	38.25	18669648
879	Phosphorylation	ILQNQRSTPEMERQR HHHCCCCCHHHHHHH	26.00	18669648
889	Phosphorylation	MERQRAVYHLATRLV HHHHHHHHHHHHHHH	7.07	-
893	Phosphorylation	RAVYHLATRLVQTAR HHHHHHHHHHHHHHH	30.78	-
912	Phosphorylation	DPDSLRIYLSNLKKK CHHHHHHHHHHHHHH	9.54	27642862
927	Phosphorylation	YKEDFPRTEQVPEKT HHHCCCCCCCCCCCC	30.89	28258704
934	Phosphorylation	TEQVPEKTEE----- CCCCCCCCCC-----	43.62	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSH4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSH4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSH4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFD3_HUMAN	VBP1	physical	12591739
MSH5_HUMAN	MSH5	physical	12591739
MLH1_HUMAN	MLH1	physical	10928988
RAD51_HUMAN	RAD51	physical	11950880
RFA1_HUMAN	RPA1	physical	11950880
MSH5_HUMAN	MSH5	physical	9787078
MSH5_HUMAN	MSH5	physical	10029069
GPS2_HUMAN	GPS2	physical	16122992
MSH5_HUMAN	MSH5	physical	16122992
PFD3_HUMAN	VBP1	physical	23964080
TERA_HUMAN	VCP	physical	23964080
VHL_HUMAN	VHL	physical	23964080
MSH5_HUMAN	MSH5	physical	16397227
EIF3F_HUMAN	EIF3F	physical	23725059

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.