PTN6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN6_RAT
• UniProt AC: P81718
• Protein Name: Tyrosine-protein phosphatase non-receptor type 6
• Gene Name: Ptpn6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 613
• Subcellular Localization: Cytoplasm . Nucleus . In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity)..
• Protein Description: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis..
• Protein Sequence: MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVYENVHSKNKKEEKVKKQRSADKEKNKGSLKRNISLTPCRGLRWADRDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GWFHRDLSGPDAETL CCCCCCCCCCCHHHH	53.20	21738781
28	Phosphorylation	KGRGVPGSFLARPSR CCCCCCCCEECCCCC	15.83	22673903
59	Phosphorylation	THIRIQNSGDFYDLY EEEEEECCCCEECCC	24.30	28689409
66	Phosphorylation	SGDFYDLYGGEKFAT CCCEECCCCCEEEEC	21.86	-
140	Phosphorylation	WTFLVRESLSQPGDF CEEEEEECCCCCCCE	23.82	22673903
142	Phosphorylation	FLVRESLSQPGDFVL EEEEECCCCCCCEEE	43.54	22673903
150	Phosphorylation	QPGDFVLSVLNDQPK CCCCEEEEEECCCCC	21.18	30181290
379	Phosphorylation	TQRVYGLYSVTNCKE CCEEEEEEEEECCCC	9.20	-
536	Phosphorylation	QSQRGQESEYGNITY HHHCCCCCCCCCCCC	28.38	28432305
538	Phosphorylation	QRGQESEYGNITYPP HCCCCCCCCCCCCCH	25.42	25532521
542	Phosphorylation	ESEYGNITYPPALRS CCCCCCCCCCHHHHH	33.69	28432305
543	Phosphorylation	SEYGNITYPPALRSA CCCCCCCCCHHHHHH	11.92	-
557	Phosphorylation	AHAKASRTSSKHKEE HHHHHHCCCHHHHHH	34.55	25575281
558	Phosphorylation	HAKASRTSSKHKEEV HHHHHCCCHHHHHHH	35.96	28432305
559	Phosphorylation	AKASRTSSKHKEEVY HHHHCCCHHHHHHHH	37.86	28432305
566	Phosphorylation	SKHKEEVYENVHSKN HHHHHHHHHHHHCCC	12.69	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
566	Y	Phosphorylation	Kinase	LYN	Q07014	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN6_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBP_MOUSE	Mbp	physical	17068200

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.