SC5A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC5A5_HUMAN
• UniProt AC: Q92911
• Protein Name: Sodium/iodide cotransporter
• Gene Name: SLC5A5
• Organism: Homo sapiens (Human).
• Sequence Length: 643
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Mediates iodide uptake in the thyroid gland..
• Protein Sequence: MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	LARGGQRSAEDFFTG HHCCCCCCHHHHCCC	28.29	22817900
66	Phosphorylation	VGLSLSASFMSAVQV CCCCCCHHHHHHHHH	20.36	-
126	Phosphorylation	EYLEMRFSRAVRLCG HHHHHHHHHHHHHHH	14.68	-
225	N-linked_Glycosylation	QVLTLAQNHSRINLM HHHHHHHCCCCEEEC	29.51	10893432
225	N-linked_Glycosylation	QVLTLAQNHSRINLM HHHHHHHCCCCEEEC	29.51	10893432
227	Phosphorylation	LTLAQNHSRINLMDF HHHHHCCCCEEECCC	42.26	24670416
377	Phosphorylation	LIKPRLRSLAPRKLV HHHHHHHHHCCCEEE	33.21	24719451
489	N-linked_Glycosylation	RCVALSVNASGLLDP HHEEEEECCCCCCCH	25.64	UniProtKB CARBOHYD
502	N-linked_Glycosylation	DPALLPANDSSRAPS CHHHCCCCCCCCCCC	48.00	UniProtKB CARBOHYD
556	Phosphorylation	LTGPTKRSTLAPGLL HHCCCCCCCCCCHHH	29.36	-
586	N-linked_Glycosylation	EVAILDDNLVKGPEE HEEEECCCCCCCCCC	46.53	10893432
586	N-linked_Glycosylation	EVAILDDNLVKGPEE HEEEECCCCCCCCCC	46.53	10893432
598	N-linked_Glycosylation	PEELPTGNKKPPGFL CCCCCCCCCCCCCCC	52.21	-
598	N-linked_Glycosylation	PEELPTGNKKPPGFL CCCCCCCCCCCCCCC	52.21	10893432
627	Phosphorylation	LEGAGSWTPCVGHDG CCCCCCCCCCCCCCC	14.43	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
556	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC5A5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC5A5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SC5A5_HUMAN	SLC5A5	physical	20797386
ORML2_HUMAN	ORMDL2	physical	28514442
SFXN5_HUMAN	SFXN5	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
ARL5B_HUMAN	ARL5B	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00081: Hashimoto's thyroiditis
• H00251: Thyroid dyshormonogenesis; Dyshormogenetic goiter
• OMIM Disease
• 274400: Thyroid dyshormonogenesis 1 (TDH1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.