SC5A6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC5A6_HUMAN
• UniProt AC: Q9Y289
• Protein Name: Sodium-dependent multivitamin transporter
• Gene Name: SLC5A6
• Organism: Homo sapiens (Human).
• Sequence Length: 635
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Transports pantothenate, biotin and lipoate in the presence of sodium..
• Protein Sequence: MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	VALSLLATFQSAVAI HHHHHHHHHHHHHHH	23.37	-
138	N-linked_Glycosylation	EYLELRFNKTVRVCG HHHHHHCCCCEECCC	32.43	UniProtKB CARBOHYD
286	Phosphorylation	QRYLSSRTEKAAVLS HHHHCCCCHHHHHHH	43.73	21570947
489	N-linked_Glycosylation	SMPPSPSNGSSFSLP CCCCCCCCCCCCCCC	58.72	UniProtKB CARBOHYD
498	N-linked_Glycosylation	SSFSLPTNLTVATVT CCCCCCCCCEEEEEE	31.60	UniProtKB CARBOHYD
511	O-linked_Glycosylation	VTTLMPLTTFSKPTG EEEECCCCCCCCCCC	21.66	OGP
526	Phosphorylation	LQRFYSLSYLWYSAH HHHHEEEEEHHHCCC	16.55	-
549	Phosphorylation	GLIVSLLTGRMRGRS HHHHHHHHCCCCCCC	28.21	21815630
556	Phosphorylation	TGRMRGRSLNPATIY HCCCCCCCCCHHHHH	35.01	22210691
561	Phosphorylation	GRSLNPATIYPVLPK CCCCCHHHHHHHHHH	23.46	22210691
563	Phosphorylation	SLNPATIYPVLPKLL CCCHHHHHHHHHHHH	5.28	22210691
576	Phosphorylation	LLSLLPLSCQKRLHC HHHHHCCCCCCCCCC	16.74	28555341
577	S-palmitoylation	LSLLPLSCQKRLHCR HHHHCCCCCCCCCCH	7.92	29575903
579	Ubiquitination	LLPLSCQKRLHCRSY HHCCCCCCCCCCHHC	62.34	-
585	Phosphorylation	QKRLHCRSYGQDHLD CCCCCCHHCCCCCCC	38.72	25849741
586	Phosphorylation	KRLHCRSYGQDHLDT CCCCCHHCCCCCCCC	10.23	26434776
593	Phosphorylation	YGQDHLDTGLFPEKP CCCCCCCCCCCCCCC	41.99	26434776
599	Ubiquitination	DTGLFPEKPRNGVLG CCCCCCCCCCCCCCC	49.90	21890473
608	Phosphorylation	RNGVLGDSRDKEAMA CCCCCCCCCCHHHHH	40.35	25159151
611	Ubiquitination	VLGDSRDKEAMALDG CCCCCCCHHHHHCCC	46.38	-
621	Phosphorylation	MALDGTAYQGSSSTC HHCCCCEECCCCCEE	17.16	27642862
624	Phosphorylation	DGTAYQGSSSTCILQ CCCEECCCCCEEEEE	12.94	24719451
625	Phosphorylation	GTAYQGSSSTCILQE CCEECCCCCEEEEEE	36.17	27251275
626	Phosphorylation	TAYQGSSSTCILQET CEECCCCCEEEEEEC	29.06	27251275
627	Phosphorylation	AYQGSSSTCILQETS EECCCCCEEEEEECC	12.91	27251275
633	Phosphorylation	STCILQETSL----- CEEEEEECCC-----	23.51	28348404
634	Phosphorylation	TCILQETSL------ EEEEEECCC------	31.18	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC5A6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC5A6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC5A6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SC5A6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00121: Biotin
• DB08872: gabapentin enacarbil
• DB00166: Lipoic Acid