S6A12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S6A12_HUMAN
• UniProt AC: P48065
• Protein Name: Sodium- and chloride-dependent betaine transporter
• Gene Name: SLC6A12
• Organism: Homo sapiens (Human).
• Sequence Length: 614
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation..
• Protein Sequence: MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	WVPEEGEKLDQEDED CCCCCCCCCCCCCHH	69.12	29967540
171	N-linked_Glycosylation	EHCTDFLNHSGAGTV HHHHHHHCCCCCCCC	27.54	UniProtKB CARBOHYD
183	N-linked_Glycosylation	GTVTPFENFTSPVME CCCCCCCCCCCHHHH	45.97	UniProtKB CARBOHYD
208	Phosphorylation	SGIHDLGSLRWELAL CCCCHHHHHHHHHHH	23.27	24719451
240	Phosphorylation	KSTGKVVYFTATFPY CCCCCEEEEEECHHH	9.74	30576142
242	Phosphorylation	TGKVVYFTATFPYLM CCCEEEEEECHHHHH	13.70	-
244	Phosphorylation	KVVYFTATFPYLMLV CEEEEEECHHHHHHH	23.29	-
259	Phosphorylation	ILLIRGVTLPGAYQG HHHHHCCCCCCHHHH	30.02	30576142
599	Phosphorylation	AGRNFGPSPTREGLI CCCCCCCCCCCCCCC	39.00	26091039
610	Ubiquitination	EGLIAGEKETHL--- CCCCCCCCCCCC---	67.98	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S6A12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S6A12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S6A12_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S6A12_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.