VIPR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIPR2_HUMAN
• UniProt AC: P41587
• Protein Name: Vasoactive intestinal polypeptide receptor 2
• Gene Name: VIPR2
• Organism: Homo sapiens (Human).
• Sequence Length: 438
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C..
• Protein Sequence: MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37 (in isoform 2)	Phosphorylation	-	34.43	22210691
53 (in isoform 2)	Phosphorylation	-	41.04	22210691
58	N-linked_Glycosylation	ACSGVWDNITCWRPA HCCCCCCCEEEECCC	18.76	UniProtKB CARBOHYD
59 (in isoform 2)	Phosphorylation	-	2.88	22210691
88	N-linked_Glycosylation	NFYSKAGNISKNCTS HHHHHCCCCCCCCCC	39.97	UniProtKB CARBOHYD
92	N-linked_Glycosylation	KAGNISKNCTSDGWS HCCCCCCCCCCCCHH	27.75	UniProtKB CARBOHYD
396	Phosphorylation	KWRSRCPTPSASRDY HHHHCCCCCCCCCCE	33.24	21949786
398	Phosphorylation	RSRCPTPSASRDYRV HHCCCCCCCCCCEEE	41.16	21949786
400	Phosphorylation	RCPTPSASRDYRVCG CCCCCCCCCCEEECC	29.98	21949786
409	Phosphorylation	DYRVCGSSFSRNGSE CEEECCCCCCCCCCC	16.72	21712546
415	Phosphorylation	SSFSRNGSEGALQFH CCCCCCCCCCCEEEC	36.08	25849741
425	Phosphorylation	ALQFHRGSRAQSFLQ CEEECCCCHHHHHHH	25.13	28555341
429	Phosphorylation	HRGSRAQSFLQTETS CCCCHHHHHHHHCCC	27.26	21955146
433	Phosphorylation	RAQSFLQTETSVI-- HHHHHHHHCCCCC--	43.29	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIPR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIPR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIPR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SNX17_HUMAN	SNX17	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
VPS8_HUMAN	VPS8	physical	28514442
PLIN3_HUMAN	PLIN3	physical	28514442
VEZA_HUMAN	VEZT	physical	28514442
CERS5_HUMAN	CERS5	physical	28514442
RBG10_HUMAN	RABGAP1L	physical	28514442
RBG1L_HUMAN	RABGAP1L	physical	28514442
S35F1_HUMAN	SLC35F1	physical	28514442
CDS1_HUMAN	CDS1	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
ELOV2_HUMAN	ELOVL2	physical	28514442
ORC5_HUMAN	ORC5	physical	28514442
CP2S1_HUMAN	CYP2S1	physical	28514442
CIP2A_HUMAN	KIAA1524	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
RINT1_HUMAN	RINT1	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
S35F2_HUMAN	SLC35F2	physical	28514442
TM245_HUMAN	TMEM245	physical	28514442
SPTCS_HUMAN	SPG11	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
PLCD_HUMAN	AGPAT4	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
UBP24_HUMAN	USP24	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
PIGN_HUMAN	PIGN	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
MTOR_HUMAN	MTOR	physical	28514442
ADCK1_HUMAN	ADCK1	physical	28514442
SG196_HUMAN	POMK	physical	28514442
YIPF4_HUMAN	YIPF4	physical	28514442
OTUL_HUMAN	OTULIN	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
OPA1_HUMAN	OPA1	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
REEP4_HUMAN	REEP4	physical	28514442
LEG1_HUMAN	LGALS1	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
ALG8_HUMAN	ALG8	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
AG10A_HUMAN	ALG10	physical	28514442
COQ8B_HUMAN	ADCK4	physical	28514442
EVI5L_HUMAN	EVI5L	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
SETX_HUMAN	SETX	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442
HMOX2_HUMAN	HMOX2	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
CERS6_HUMAN	CERS6	physical	28514442
VPS18_HUMAN	VPS18	physical	28514442
BTAF1_HUMAN	BTAF1	physical	28514442
AIG1_HUMAN	AIG1	physical	28514442
BRAT1_HUMAN	BRAT1	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
CKLF4_HUMAN	CMTM4	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442
FAKD1_HUMAN	FASTKD1	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
RAB21_HUMAN	RAB21	physical	28514442
EBP_HUMAN	EBP	physical	28514442
CO061_HUMAN	C15orf61	physical	28514442
DYM_HUMAN	DYM	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
HSDL1_HUMAN	HSDL1	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
SAAL1_HUMAN	SAAL1	physical	28514442
TM41A_HUMAN	TMEM41A	physical	28514442
DAD1_HUMAN	DAD1	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442
MAVS_HUMAN	MAVS	physical	28514442
BZW2_HUMAN	BZW2	physical	28514442
TM164_HUMAN	TMEM164	physical	28514442
LMBD2_HUMAN	LMBRD2	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
DAAF5_HUMAN	DNAAF5	physical	28514442
SURF4_HUMAN	SURF4	physical	28514442
ATPA_HUMAN	ATP5A1	physical	28514442
ZW10_HUMAN	ZW10	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
TM246_HUMAN	TMEM246	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.