SPTCS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTCS_HUMAN
• UniProt AC: Q96JI7
• Protein Name: Spatacsin
• Gene Name: SPG11
• Organism: Homo sapiens (Human).
• Sequence Length: 2443
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . Cell projection, axon . Cell projection, dendrite . Mainly cytoplasmic.
• Protein Description: May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport..
• Protein Sequence: MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWEDSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPERDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDVAVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCAPWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTITLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENRQLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTEELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEELIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQIQSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWIGEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHSQFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTLAIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLELLGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFCRLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTDLFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTRQKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELGKLLQLFVEREHLFSDGPDVKKLCILCQILKDTSIAINHTIITSYSIENLQHECRSILERLQTDGQFALARRVAELAELPVDNLVIKEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKKNSISSKAASSFFSTQAHVACEHPTGWSSMEERHLLLTLAGHWLAQEDVVPLDKLEELEKQIWLCRITQHTLGRNQEETEPRFSRQISTSGELSFDSLASEFSFSKLAALNTSKYLELNSLPSKETCENRLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASGEASMEDLHPEIHALLQSAELLEEEAPDIPLRRVHSTSSLDSQKFVTVPSSNEVVTNLEVLTSKCLHGKNYCRQVLCLYDLAKELGCSYTDVAAQDGEAMLRKILASQQPDRCKRAQAFISTQGLKPDTVAELVAEEVTRELLTSSQGTGHKQMFNPTEESQTFLQLTTLCQDRTLVGMKLLDKISSVPHGELSCTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVVRLLTGIGRYNEMTYIFDLLHKKHYFEVLMRKKLDPSGTLKTALLDYIKRCRPGDSEKHNMIALCFSMCREIGENHEAAARIQLKLIESQPWEDSLKDGHQLKQLLLKALTLMLDAAESYAKDSCVRQAQHCQRLTKLITLQIHFLNTGQNTMLINLGRHKLMDCILALPRFYQASIVAEAYDFVPDWAEILYQQVILKGDFNYLEEFKQQRLLKSSIFEEISKKYKQHQPTDMVMENLKKLLTYCEDVYLYYKLAYEHKFYEIVNVLLKDPQTGCCLKDMLAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	LIDDQDISISLLSLR HCCCCCCCHHHHHHH	17.89	-
311	Ubiquitination	DLPIQGPKGVDEDDP CCCCCCCCCCCCCCC	77.66	23503661
311 (in isoform 2)	Ubiquitination	-	77.66	-
326	Ubiquitination	VNSAYNMKLAKFSFQ CCHHHHHCHHEEEEE	41.47	21906983
326 (in isoform 1)	Ubiquitination	-	41.47	21890473
326 (in isoform 2)	Ubiquitination	-	41.47	21890473
329	Ubiquitination	AYNMKLAKFSFQIDR HHHHCHHEEEEECCH	52.56	22817900
331	Phosphorylation	NMKLAKFSFQIDRSW HHCHHEEEEECCHHH	18.61	-
339	Ubiquitination	FQIDRSWKAQLSSLN EECCHHHHHHHHHHH	27.74	29967540
350	Ubiquitination	SSLNETIKNSKLEVS HHHHHHHHHCCCEEE	63.69	21906983
350 (in isoform 1)	Ubiquitination	-	63.69	21890473
350 (in isoform 2)	Ubiquitination	-	63.69	21890473
353	Ubiquitination	NETIKNSKLEVSCCA HHHHHHCCCEEEEEC	59.05	22817900
414	Ubiquitination	SDPGRSWKIMHISEQ CCCCCCEEEEEECCC	31.25	29967540
530	Ubiquitination	WGRCSIPIHALEAGI CCCCCCCHHHHHHCC	2.57	23503661
536	Ubiquitination	PIHALEAGIENRQLD CHHHHHHCCCCCCCC	20.54	23503661
550	Ubiquitination	DTVNFFLKSKENLFN CCHHHHHCCCHHCCC	55.09	-
552	Ubiquitination	VNFFLKSKENLFNPS HHHHHCCCHHCCCCC	49.38	29967540
561	Ubiquitination	NLFNPSSKSSVSDQF HCCCCCCCCCHHHHH	51.60	-
562	Phosphorylation	LFNPSSKSSVSDQFD CCCCCCCCCHHHHHH	37.61	30108239
563	Phosphorylation	FNPSSKSSVSDQFDH CCCCCCCCHHHHHHH	29.40	30108239
565	Phosphorylation	PSSKSSVSDQFDHLS CCCCCCHHHHHHHHH	27.87	30108239
598	Phosphorylation	CSAIRESYSEPQSKH HHHHHHHCCCCCHHH	16.58	26546556
612	N-linked_Glycosylation	HFSEQLLNLTLSFLN HHHHHHHHHHHHHHH	39.30	UniProtKB CARBOHYD
644	Phosphorylation	QKGVNILTSYINELR HHHHHHHHHHHHHHH	18.71	-
660	Ubiquitination	FMIKFPWKLTDAIDE HHHCCCCCCCCCCCC	41.57	29967540
668	Phosphorylation	LTDAIDEYDVHENVP CCCCCCCCCCCCCCC	21.37	28796482
676	Ubiquitination	DVHENVPKVKESNIW CCCCCCCCCCCCCHH	62.75	29967540
678	Ubiquitination	HENVPKVKESNIWKK CCCCCCCCCCCHHHC	62.64	29967540
683	Ubiquitination	KVKESNIWKKLSFEE CCCCCCHHHCCCHHH	8.93	22505724
687	Phosphorylation	SNIWKKLSFEEVIAS CCHHHCCCHHHHHHH	39.22	-
739	Ubiquitination	NLKKNNIKEASELLK HHHHCCHHHHHHHHH	49.72	29967540
746	Ubiquitination	KEASELLKNMGFDVK HHHHHHHHHCCCCCC	58.47	29967540
777	Ubiquitination	DFLVEILKEKNYFSE HHHHHHHHHCCCCCH	72.76	29967540
785	Ubiquitination	EKNYFSEKEKRTIDF HCCCCCHHHHCHHHH	68.30	-
812	Ubiquitination	QENMQIQSFPRYWIK HHCCCCCCCCCHHCC	38.56	21890473
819	Ubiquitination	SFPRYWIKEQDFFKH CCCCHHCCHHHCCCC	34.87	22817900
819 (in isoform 1)	Ubiquitination	-	34.87	21890473
819 (in isoform 2)	Ubiquitination	-	34.87	21890473
825	Methylation	IKEQDFFKHKSVLDS CCHHHCCCCHHHHHH	50.55	115980629
825	Ubiquitination	IKEQDFFKHKSVLDS CCHHHCCCCHHHHHH	50.55	-
827	Ubiquitination	EQDFFKHKSVLDSFL HHHCCCCHHHHHHHH	42.73	29967540
828	Phosphorylation	QDFFKHKSVLDSFLK HHCCCCHHHHHHHHC	27.86	29514088
832	Phosphorylation	KHKSVLDSFLKYDCK CCHHHHHHHHCCCCC	28.46	29514088
835	Ubiquitination	SVLDSFLKYDCKDEF HHHHHHHCCCCCCCC	36.71	29967540
839	Ubiquitination	SFLKYDCKDEFNKQD HHHCCCCCCCCCCCC	58.35	-
844	Ubiquitination	DCKDEFNKQDHRIVL CCCCCCCCCCHHHEE	63.52	-
876	Ubiquitination	RISPEEYKSYSPEAL CCCHHHHHHCCHHHH	46.31	21906983
876 (in isoform 1)	Ubiquitination	-	46.31	21890473
876 (in isoform 2)	Ubiquitination	-	46.31	21890473
942	Ubiquitination	MRNEILDKLARNGVF HHHHHHHHHHHCCCE	40.37	29901268
974	Phosphorylation	IGGVIQDTLPVQNYK CCCEECCCCCCCCCC	19.31	24719451
980	Phosphorylation	DTLPVQNYKTKEGWD CCCCCCCCCCCCCCC	11.71	24719451
981	Ubiquitination	TLPVQNYKTKEGWDF CCCCCCCCCCCCCCH	61.75	21906983
981 (in isoform 1)	Ubiquitination	-	61.75	21890473
981 (in isoform 2)	Ubiquitination	-	61.75	21890473
983	Ubiquitination	PVQNYKTKEGWDFHS CCCCCCCCCCCCHHH	50.51	22817900
1024	Ubiquitination	ENCPFLEKKELHEAH HHCCCCCHHHHHHHC	54.41	29967540
1046	N-linked_Glycosylation	QCRQVASNLTDPKLI HHHHHHHHCCCHHHH	36.90	UniProtKB CARBOHYD
1048	Phosphorylation	RQVASNLTDPKLIFQ HHHHHHCCCHHHHHH	55.28	24719451
1110	Ubiquitination	ENENCLKKVDPQLLK CCCCHHHHCCHHHHH	38.63	29967540
1117	Acetylation	KVDPQLLKMALTPYP HCCHHHHHHHCCCCC	30.62	25953088
1117	Malonylation	KVDPQLLKMALTPYP HCCHHHHHHHCCCCC	30.62	26320211
1117	Ubiquitination	KVDPQLLKMALTPYP HCCHHHHHHHCCCCC	30.62	29967540
1127	Ubiquitination	LTPYPKLKTALFPQC CCCCCCCCCCCCCCC	37.57	-
1167	Ubiquitination	RLFGWQSANTLAIGD HCCCCCCCCCEEECH	9.64	21890473
1290	Phosphorylation	CRNEDAQYSFIRESV CCCCCCCHHHHHHHH	13.79	27642862
1291	Phosphorylation	RNEDAQYSFIRESVA CCCCCCHHHHHHHHH	11.34	-
1296	Phosphorylation	QYSFIRESVAEKLSK CHHHHHHHHHHHHHH	19.44	-
1300	Ubiquitination	IRESVAEKLSKLADG HHHHHHHHHHHHCCC	48.61	29967540
1303	Ubiquitination	SVAEKLSKLADGEKT HHHHHHHHHCCCCCC	59.12	29967540
1417	Ubiquitination	LPSVPTSKMDSDQVC CCCCCCCCCCHHHHH	49.56	-
1426	Ubiquitination	DSDQVCNKCPQELQG CHHHHHHCCCHHHCC	42.01	-
1571	Ubiquitination	NYKEAEAKLLEFQKS CHHHHHHHHHHHHHH	45.14	23503661
1577	Ubiquitination	AKLLEFQKSLETLNT HHHHHHHHHHHHHHH	63.43	23503661
1577 (in isoform 2)	Ubiquitination	-	63.43	-
1578	Phosphorylation	KLLEFQKSLETLNTA HHHHHHHHHHHHHHH	22.21	20071362
1587	Phosphorylation	ETLNTAATKVHPVIP HHHHHHHHCCCCCCC	31.00	20071362
1640	Ubiquitination	FSDGPDVKKLCILCQ CCCCCCHHHHHHHHH	47.62	29967540
1706	Ubiquitination	PVDNLVIKEITQEMQ CCCCCHHHHHHHHHH	35.27	-
1709	Phosphorylation	NLVIKEITQEMQTLK CCHHHHHHHHHHHHH	21.40	-
1714	Phosphorylation	EITQEMQTLKHIEQW HHHHHHHHHHHHHHH	36.14	-
1716	Ubiquitination	TQEMQTLKHIEQWSL HHHHHHHHHHHHHCH	46.02	29967540
1724	Ubiquitination	HIEQWSLKQARIDFW HHHHHCHHHHHHHHH	36.07	22505724
1732	Ubiquitination	QARIDFWKKCHENFK HHHHHHHHHHHHHHH	45.58	-
1739	Ubiquitination	KKCHENFKKNSISSK HHHHHHHHHCCCCHH	63.73	29967540
1746	Ubiquitination	KKNSISSKAASSFFS HHCCCCHHHHHHHHC	40.98	-
1793	Sumoylation	EDVVPLDKLEELEKQ CCCCCHHHHHHHHHH	66.53	-
1793	Sumoylation	EDVVPLDKLEELEKQ CCCCCHHHHHHHHHH	66.53	-
1805	Ubiquitination	EKQIWLCRITQHTLG HHHHHHHHHHHHHCC	32.58	21890473
1827	Phosphorylation	PRFSRQISTSGELSF CCCCCCCCCCCCCCH	14.26	26657352
1828	Phosphorylation	RFSRQISTSGELSFD CCCCCCCCCCCCCHH	42.24	27273156
1829	Phosphorylation	FSRQISTSGELSFDS CCCCCCCCCCCCHHH	24.39	28348404
1833	Phosphorylation	ISTSGELSFDSLASE CCCCCCCCHHHHHHH	23.78	28102081
1842	Phosphorylation	DSLASEFSFSKLAAL HHHHHHCCHHHHHHH	25.26	24719451
1853	Ubiquitination	LAALNTSKYLELNSL HHHHCCCCCHHHCCC	52.39	21890473
1853	Ubiquitination	LAALNTSKYLELNSL HHHHCCCCCHHHCCC	52.39	22817900
1853 (in isoform 1)	Ubiquitination	-	52.39	21890473
1853 (in isoform 2)	Ubiquitination	-	52.39	21890473
1854	Phosphorylation	AALNTSKYLELNSLP HHHCCCCCHHHCCCC	12.74	25262027
1862	Phosphorylation	LELNSLPSKETCENR HHHCCCCCHHHHHCC	48.71	24719451
1863	Ubiquitination	ELNSLPSKETCENRL HHCCCCCHHHHHCCC	55.92	29967540
1955	Phosphorylation	IPLRRVHSTSSLDSQ CCCEECCCCCCCCCC	27.42	23401153
1956	Phosphorylation	PLRRVHSTSSLDSQK CCEECCCCCCCCCCC	13.88	25159151
1957	Phosphorylation	LRRVHSTSSLDSQKF CEECCCCCCCCCCCE	31.73	29255136
1958	Phosphorylation	RRVHSTSSLDSQKFV EECCCCCCCCCCCEE	35.96	23401153
1961	Phosphorylation	HSTSSLDSQKFVTVP CCCCCCCCCCEEECC	40.33	17525332
1963	Ubiquitination	TSSLDSQKFVTVPSS CCCCCCCCEEECCCC	45.84	-
1966	Phosphorylation	LDSQKFVTVPSSNEV CCCCCEEECCCCCCE	29.81	18669648
1969	Phosphorylation	QKFVTVPSSNEVVTN CCEEECCCCCCEEEE	41.27	30177828
1970	Phosphorylation	KFVTVPSSNEVVTNL CEEECCCCCCEEEEH	30.82	30177828
1975	Phosphorylation	PSSNEVVTNLEVLTS CCCCCEEEEHHHHHH	38.98	30177828
1981	Phosphorylation	VTNLEVLTSKCLHGK EEEHHHHHHHHCCCC	31.17	20873877
1982	Phosphorylation	TNLEVLTSKCLHGKN EEHHHHHHHHCCCCC	19.74	20873877
1983	Ubiquitination	NLEVLTSKCLHGKNY EHHHHHHHHCCCCCH	35.26	29967540
1986	Ubiquitination	VLTSKCLHGKNYCRQ HHHHHHCCCCCHHHH	55.44	29967540
1988	Ubiquitination	TSKCLHGKNYCRQVL HHHHCCCCCHHHHHH	33.71	29967540
2022	Ubiquitination	DGEAMLRKILASQQP CHHHHHHHHHHHCCC	37.80	29967540
2045	Ubiquitination	FISTQGLKPDTVAEL HHHCCCCCHHHHHHH	47.90	29967540
2071	Ubiquitination	SSQGTGHKQMFNPTE CCCCCCCCCCCCCCH	44.81	29967540
2095	Ubiquitination	TLCQDRTLVGMKLLD HHCCCCCHHCHHHHH	3.06	21890473
2099	Ubiquitination	DRTLVGMKLLDKISS CCCHHCHHHHHHHHC	39.71	29967540
2131	Ubiquitination	HCFTLTCHMEGIIRV HHHHHHHHHHHHHHH	16.46	29967540
2143	Ubiquitination	IRVLQAAHMLTDNHL HHHHHHHHHHCCCCC	18.14	29967540
2160	Ubiquitination	SEEYGLVVRLLTGIG HHHHHHHHHHHHCCC	4.25	21890473
2169	Phosphorylation	LLTGIGRYNEMTYIF HHHCCCCHHCHHHHH	15.40	22817900
2172	Ubiquitination	GIGRYNEMTYIFDLL CCCCHHCHHHHHHHH	2.84	21890473
2173	Phosphorylation	IGRYNEMTYIFDLLH CCCHHCHHHHHHHHC	13.79	-
2174	Phosphorylation	GRYNEMTYIFDLLHK CCHHCHHHHHHHHCC	9.78	22817900
2182	"N6,N6-dimethyllysine"	IFDLLHKKHYFEVLM HHHHHCCHHHHHHHH	32.56	-
2182	Methylation	IFDLLHKKHYFEVLM HHHHHCCHHHHHHHH	32.56	23644510
2192	Ubiquitination	FEVLMRKKLDPSGTL HHHHHHCCCCCCCCH	48.00	-
2208	Ubiquitination	TALLDYIKRCRPGDS HHHHHHHHHCCCCCC	38.94	22817900
2208 (in isoform 1)	Ubiquitination	-	38.94	21890473
2226	Phosphorylation	NMIALCFSMCREIGE HHHHHHHHHHHHHHC	18.90	-
2244	Ubiquitination	AAARIQLKLIESQPW HHHHHHHHHHHCCCC	30.92	29967540
2248	Phosphorylation	IQLKLIESQPWEDSL HHHHHHHCCCCCHHC	34.25	28258704
2254	Phosphorylation	ESQPWEDSLKDGHQL HCCCCCHHCCCHHHH	26.29	28258704
2255	Ubiquitination	SQPWEDSLKDGHQLK CCCCCHHCCCHHHHH	10.17	29967540
2256	Ubiquitination	QPWEDSLKDGHQLKQ CCCCHHCCCHHHHHH	66.66	29967540
2261	Ubiquitination	SLKDGHQLKQLLLKA HCCCHHHHHHHHHHH	2.95	29967540
2270	Ubiquitination	QLLLKALTLMLDAAE HHHHHHHHHHHHHHH	18.25	29967540
2281	Ubiquitination	DAAESYAKDSCVRQA HHHHHHHHHHHHHHH	41.77	-
2368	Ubiquitination	FNYLEEFKQQRLLKS CCHHHHHHHHHHHHH	49.12	29967540
2374	Ubiquitination	FKQQRLLKSSIFEEI HHHHHHHHHHHHHHH	46.91	29967540
2383	Ubiquitination	SIFEEISKKYKQHQP HHHHHHHHHHHHCCC	66.82	29967540
2399	2-Hydroxyisobutyrylation	DMVMENLKKLLTYCE HHHHHHHHHHHHHHH	53.62	-
2404	Phosphorylation	NLKKLLTYCEDVYLY HHHHHHHHHHHHHHH	8.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPTCS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTCS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTCS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPTCS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00266: Hereditary spastic paraplegia (SPG)
• OMIM Disease
• 604360: Spastic paraplegia 11, autosomal recessive (SPG11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1955; SER-1958 ANDSER-1961, AND MASS SPECTROMETRY.
PubMed: 17525332