SESQ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESQ2_HUMAN
• UniProt AC: Q6ICB4
• Protein Name: Sesquipedalian-2 {ECO:0000305|PubMed:20133602}
• Gene Name: PHETA2 {ECO:0000312|HGNC:HGNC:27161}
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Early endosome . Recycling endosome . Golgi apparatus, trans-Golgi network . Cytoplasmic vesicle, clathrin-coated vesicle . Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
• Protein Description: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane..
• Protein Sequence: MKLNERSVAHYALSDSPADHMGFLRTWGGPGTPPTPSGTGRRCWFVLKGNLLFSFESREGRAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKVLSRASFGYMRLVVRELESQLQDARQSLALQRRSSWKSVASRCKPQAPNHRAAGLENGHCLSKDSSPVGLVEEAGSRSAGWGLAEWELQGPASLLLGKGQSPVSPETSCFSTLHDWYGQEIVELRQCWQKRAQGSHSKCEEQDRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKLNERSVAHYALS -CCCCHHHHHHHHHC	19.92	-
26	Phosphorylation	DHMGFLRTWGGPGTP CCCCCCCCCCCCCCC	30.52	21712546
32	Phosphorylation	RTWGGPGTPPTPSGT CCCCCCCCCCCCCCC	29.27	21712546
35	Phosphorylation	GGPGTPPTPSGTGRR CCCCCCCCCCCCCCC	31.15	21712546
37	Phosphorylation	PGTPPTPSGTGRRCW CCCCCCCCCCCCCEE	52.01	21712546
39	Phosphorylation	TPPTPSGTGRRCWFV CCCCCCCCCCCEEEE	31.67	29449344
54	Phosphorylation	LKGNLLFSFESREGR EECCEEEEEECCCCC	28.24	-
57	Phosphorylation	NLLFSFESREGRAPL CEEEEEECCCCCCCE	33.35	-
148	Phosphorylation	SLALQRRSSWKSVAS HHHHHHHHHHHHHHH	42.62	24719451
149	Phosphorylation	LALQRRSSWKSVASR HHHHHHHHHHHHHHH	36.39	-
176	Phosphorylation	LENGHCLSKDSSPVG CCCCCCCCCCCCCCE	39.55	21712546
179	Phosphorylation	GHCLSKDSSPVGLVE CCCCCCCCCCCEEEE	40.03	23401153
180	Phosphorylation	HCLSKDSSPVGLVEE CCCCCCCCCCEEEEC	33.47	29255136
207	Phosphorylation	WELQGPASLLLGKGQ EEEECCHHHEECCCC	23.76	27251275
215	Phosphorylation	LLLGKGQSPVSPETS HEECCCCCCCCCCCC	35.62	28348404
218	Phosphorylation	GKGQSPVSPETSCFS CCCCCCCCCCCCHHH	22.02	29978859
221	Phosphorylation	QSPVSPETSCFSTLH CCCCCCCCCHHHCHH	33.89	29978859
222	Phosphorylation	SPVSPETSCFSTLHD CCCCCCCCHHHCHHH	16.11	29978859
225	Phosphorylation	SPETSCFSTLHDWYG CCCCCHHHCHHHHHC	34.09	29978859
226	Phosphorylation	PETSCFSTLHDWYGQ CCCCHHHCHHHHHCH	14.09	29978859
231	Phosphorylation	FSTLHDWYGQEIVEL HHCHHHHHCHHHHHH	18.26	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESQ2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESQ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESQ2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OCRL_HUMAN	OCRL	physical	20133602
PKHJ1_HUMAN	PLEKHJ1	physical	28514442
I5P2_HUMAN	INPP5B	physical	28514442
OCRL_HUMAN	OCRL	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.