MELPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MELPH_HUMAN
• UniProt AC: Q9BV36
• Protein Name: Melanophilin
• Gene Name: MLPH
• Organism: Homo sapiens (Human).
• Sequence Length: 600
• Subcellular Localization: Cytoplasm.
• Protein Description: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A..
• Protein Sequence: MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	ARVVKIGSLEWYYEH EEEEEECCHHHHHHH	26.96	28348404
121	Phosphorylation	KIGSLEWYYEHVKAR EECCHHHHHHHHHHH	6.93	27642862
122	Phosphorylation	IGSLEWYYEHVKARF ECCHHHHHHHHHHHH	10.71	27642862
136	Ubiquitination	FKRFGSAKVIRSLHG HHHHCCHHHHHHHHC	39.63	21906983
136 (in isoform 2)	Ubiquitination	-	39.63	21906983
136 (in isoform 1)	Ubiquitination	-	39.63	21906983
136	Ubiquitination	FKRFGSAKVIRSLHG HHHHCCHHHHHHHHC	39.63	2190698
136	Ubiquitination	FKRFGSAKVIRSLHG HHHHCCHHHHHHHHC	39.63	21906983
140	Phosphorylation	GSAKVIRSLHGRLQG CCHHHHHHHHCHHCC	17.37	28348404
155	Phosphorylation	GAGPELISEERSGDS CCCHHHCCCCCCCCC	46.13	29255136
159	Phosphorylation	ELISEERSGDSDQTD HHCCCCCCCCCCCCC	50.67	30278072
162	Phosphorylation	SEERSGDSDQTDEDG CCCCCCCCCCCCCCC	34.83	30278072
165	Phosphorylation	RSGDSDQTDEDGEPG CCCCCCCCCCCCCCC	46.47	30278072
173	Phosphorylation	DEDGEPGSEAQAQAQ CCCCCCCHHHHHHCC	40.24	28985074
184	Phosphorylation	AQAQPFGSKKKRLLS HHCCCCCCCCCEEEE	41.50	27251789
185	Acetylation	QAQPFGSKKKRLLSV HCCCCCCCCCEEEEE	63.79	7824241
191	Phosphorylation	SKKKRLLSVHDFDFE CCCCEEEEEEECCCC	23.23	25849741
201	Phosphorylation	DFDFEGDSDDSTQPQ ECCCCCCCCCCCCCC	54.92	27362937
204	Phosphorylation	FEGDSDDSTQPQGHS CCCCCCCCCCCCCCE	33.65	28188228
205	Phosphorylation	EGDSDDSTQPQGHSL CCCCCCCCCCCCCEE	51.79	25404012
211	Phosphorylation	STQPQGHSLHLSSVP CCCCCCCEEECCCCC	25.06	27251275
215	Phosphorylation	QGHSLHLSSVPEARD CCCEEECCCCCCCCC	20.67	27251275
216	Phosphorylation	GHSLHLSSVPEARDS CCEEECCCCCCCCCC	48.31	27251275
223	Phosphorylation	SVPEARDSPQSLTDE CCCCCCCCCCCCCCH	21.20	25849741
226	Phosphorylation	EARDSPQSLTDESCS CCCCCCCCCCCHHHH	36.30	25849741
228	Phosphorylation	RDSPQSLTDESCSEK CCCCCCCCCHHHHCC	42.86	29255136
231	Phosphorylation	PQSLTDESCSEKAAP CCCCCCHHHHCCCCC	26.25	29255136
233	Phosphorylation	SLTDESCSEKAAPHK CCCCHHHHCCCCCCC	51.95	29255136
249	Phosphorylation	EGLEEADTGASGCHS CCCHHCCCCCCCCCC	41.52	29255136
252	Phosphorylation	EEADTGASGCHSHPE HHCCCCCCCCCCCCC	43.21	29255136
256	Phosphorylation	TGASGCHSHPEEQPT CCCCCCCCCCCCCCC	44.83	26657352
263	Phosphorylation	SHPEEQPTSISPSRH CCCCCCCCCCCCCCC	38.08	29255136
264	Phosphorylation	HPEEQPTSISPSRHG CCCCCCCCCCCCCCC	27.96	29255136
266	Phosphorylation	EEQPTSISPSRHGAL CCCCCCCCCCCCCCH	19.31	29255136
268	Phosphorylation	QPTSISPSRHGALAE CCCCCCCCCCCCHHH	30.07	29255136
295	Phosphorylation	GTAAALGSNVIRNEQ HHHHHHCCCCCCCCC	28.86	27251275
296 (in isoform 3)	Phosphorylation	-	31.28	30206219
297 (in isoform 3)	Phosphorylation	-	4.69	25849741
299 (in isoform 3)	Phosphorylation	-	36.03	25850435
307	Phosphorylation	NEQLPLQYLADVDTS CCCCCCEEEECCCCC	16.13	25850435
313	Phosphorylation	QYLADVDTSDEESIR EEEECCCCCCHHHHH	37.62	30278072
314	Phosphorylation	YLADVDTSDEESIRA EEECCCCCCHHHHHH	38.26	30278072
318	Phosphorylation	VDTSDEESIRAHVMA CCCCCHHHHHHHHHH	18.48	27251789
326	Phosphorylation	IRAHVMASHHSKRRG HHHHHHHHCCCCCCC	12.02	28348404
336 (in isoform 2)	Phosphorylation	-	33.02	30206219
336	Phosphorylation	SKRRGRASSESQIFE CCCCCCCCCHHHHHH	33.02	23927012
337 (in isoform 2)	Phosphorylation	-	40.04	25849741
337	Phosphorylation	KRRGRASSESQIFEL CCCCCCCCHHHHHHH	40.04	29255136
339 (in isoform 2)	Phosphorylation	-	30.44	25850435
339	Phosphorylation	RGRASSESQIFELNK CCCCCCHHHHHHHHH	30.44	25850435
364 (in isoform 3)	Phosphorylation	-	17.53	25850435
368 (in isoform 3)	Phosphorylation	-	63.45	30243723
393	Phosphorylation	RRKLEELTSNVSDQE HHHHHHHHHCCCCCC	22.87	24702127
394	Phosphorylation	RKLEELTSNVSDQET HHHHHHHHCCCCCCC	48.10	24702127
397	Phosphorylation	EELTSNVSDQETSSE HHHHHCCCCCCCCCH	37.51	25849741
401	Phosphorylation	SNVSDQETSSEEEEA HCCCCCCCCCHHHHH	31.74	25849741
402	Phosphorylation	NVSDQETSSEEEEAK CCCCCCCCCHHHHHH	34.69	25849741
403	Phosphorylation	VSDQETSSEEEEAKD CCCCCCCCHHHHHHH	57.35	25849741
420	Phosphorylation	AEPNRDKSVGPLPQA CCCCCCCCCCCCCCC	36.27	25849741
433	Phosphorylation	QADPEVGTAAHQTNR CCCHHHCCHHHHCCC	26.33	29255136
444	Phosphorylation	QTNRQEKSPQDPGDP HCCCCCCCCCCCCCC	27.35	27362937
454	Phosphorylation	DPGDPVQYNRTTDEE CCCCCCCCCCCCHHH	13.57	26657352
457	Phosphorylation	DPVQYNRTTDEELSE CCCCCCCCCHHHHHH	34.65	25849741
458	Phosphorylation	PVQYNRTTDEELSEL CCCCCCCCHHHHHHH	37.87	25849741
463	Phosphorylation	RTTDEELSELEDRVA CCCHHHHHHHHHHEE	43.33	25849741
481	Phosphorylation	SEVQQAESEVSDIES HHHHHHHHHHHHHHH	46.44	25849741
484	Phosphorylation	QQAESEVSDIESRIA HHHHHHHHHHHHHHH	28.90	30278072
488	Phosphorylation	SEVSDIESRIAALRA HHHHHHHHHHHHHHH	29.35	30278072
510	Phosphorylation	SGKPRRKSNLPIFLP CCCCCCCCCCCCCHH	41.61	22617229
552	Phosphorylation	YLLRRKFSNSLKSQG HHHHHHHHHHHHHCC	28.66	25849741
554	Phosphorylation	LRRKFSNSLKSQGKD HHHHHHHHHHHCCCC	35.66	29496963
560	Ubiquitination	NSLKSQGKDDDSFDR HHHHHCCCCCCCCCH	50.80	-
564	Phosphorylation	SQGKDDDSFDRKSVY HCCCCCCCCCHHHHH	35.72	28348404
569	Phosphorylation	DDSFDRKSVYRGSLT CCCCCHHHHHHCCCC	25.85	22617229
571	Phosphorylation	SFDRKSVYRGSLTQR CCCHHHHHHCCCCCC	19.15	22985185
574	Phosphorylation	RKSVYRGSLTQRNPN HHHHHHCCCCCCCCC	21.17	25849741
576	Phosphorylation	SVYRGSLTQRNPNAR HHHHCCCCCCCCCCC	27.46	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MELPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MELPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MELPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB27A_HUMAN	RAB27A	physical	15059972
MYO5A_HUMAN	MYO5A	physical	15059972
ACTS_HUMAN	ACTA1	physical	15059972
RB27A_HUMAN	RAB27A	physical	11773082
RAB10_HUMAN	RAB10	physical	11773082

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609227: Griscelli syndrome 3 (GS3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.